The Effect of Structured Lifestyle Modification and Yoga Practice on Metabolic Processes Associated With Cardiovascular Disease

ID#: NCT05250310

Age: 18 - 80 years

Gender: All

Healthy Subjects: No

Study Phase: N/A

Recruitment Status: Recruiting

Start Date: January 24, 2022

End Date: December 01, 2023

Contact Information:
Yuliya Vengrenyuk
Summary: The aim of the prospective randomized single center study is to evaluate the effect of a short-term (16 weeks) yoga program on micro RNA (miRNA) expression and cardiovascular disease (CVD) risk factors in patients with CVD.

Inclusion criteria:

- Subjects eligible for the study are 18-80 year old adults.

- Underwent percutaneous coronary intervention (PCI) at the catheterization lab of Mount Sinai Hospital (New York, New York) or have non-obstructive coronary artery disease and at least one CVD risk factor (hypertension, hypercholesterolemia, diabetes mellitus, or obesity) or metabolic abnormality (fasting plasma glucose ≥ 100 mg/dl, documented previous diagnosis of hypertension, serum triglycerides ≥ 150 mg/dl, or HDL cholesterol < 40 mg/dl).

- Subjects diagnosed with metabolic syndrome, which is defined as three or more of the following conditions: (1) Central or abdominal obesity (waist circumference > 40 inches for men and > 35 inches for women); (2) High triglycerides (≥150 mg/dL or triglycerides treatment); (3) Low HDL cholesterol (<40 mg/dL for men and <50 mg/dL for women) or low HDL-C treatment; (4) High blood pressure (≥130/85 mmHg) or antihypertensive medications; (5) High fasting glucose (≥100 mg/dL) or type 2 diabetes mellitus.

- Participants must be able to willingly consent to study participation and must be able to comply with the study requirements.

Exclusion Criteria:

- Physical/psychological limitation or unwillingness to practice yoga,

- Congestive heart failure, known arrthymias or prior Automated Implantable Cardioverter-Defibrillator /pacemaker or any metallic implants,

- Rheumatological/immunological diseases,

- History of transplant,

- Moderate to severe chronic obstructive pulmonary disease, debilitating or severe systemic Illness,

- Subjects who are pregnant or postpartum less than 6 months,

- Liver disease or alcohol use of more than 7 alcoholic drinks/week in women and more than 14 drinks/week in men