Social Determinants of Health, Medication Use, and Quality of Life in Inflammatory Bowel Disease
Optimizing health related-quality of life (HRQoL) for patients with inflammatory bowel
disease (IBD), who often experience a relapsing disease course, is an essential component of
care. Improving IBD disease control is linked to increased health-related quality of l...
Age: 18 years - 66+
Gender: All
Study to Evaluate the Efficacy, Safety, and Tolerability of an Anti-MTBR Tau Monoclonal Antibody (BMS-986446) in Participants With Early Alzheimer's Disease
The purpose of this study is to assess the effectiveness, safety, and tolerability of
BMS-986446 an Anti-MTBR Tau Monoclonal Antibody in participants with Early Alzheimer's
Disease.
Age: 50 - 80 years
Gender: All
Pregnant Women With and Without Crohns Disease to Explore the Role of Plastics and Toxins in Intestinal Inflammation
The PLANET Study aims to determine the impact of microplastics on intestinal inflammation and
gut microbiome in order to understand the role of this pollutant on the risk of developing
inflammatory bowel disease (IBD) as well as other diseases. With this information...
Age: 18 years - 66+
Gender: All
Testing the Role of DNA Released From Tumor Cells Into the Blood in Guiding the Use of Immunotherapy After Surgical Removal of the Bladder for Bladder Cancer Treatment, MODERN Study
This phase II/III trial examines whether patients who have undergone surgical removal of
bladder, but require an additional treatment called immunotherapy to help prevent their
bladder cancer from coming back, can be identified by a blood test. Many types of tumors ...
Age: 18 years - 66+
Gender: All
Longitudinal Cortical Demyelination in Multiple Sclerosis and Related Disorders
In this protocol, a combination of MRI, blood, and cerebrospinal fluid (CSF) analysis will be
used to understand the natural history, underlying immunologic mechanisms, and clinical
implications of central nervous system (CNS) lesions, in particular lesions in the c...
Age: 18 years - 66+
Gender: All
SELUTION 4 De Novo Small Vessel IDE Trial
Prospective, randomized controlled, single-blind, multicenter, clinical trial to demonstrate
the safety and efficacy of the SELUTION SLR 014 PTCA DEB for treatment of de novo lesions in
small coronary vessels, defined as reference vessel diameter (RVD) of 2.00 mm to...
Age: 18 years - 66+
Gender: All
A Study of NST-6179 in Adult Subjects With Intestinal Failure-Associated Liver Disease (IFALD).
This is a phase 2a, multicenter, randomized, double-blind, placebo-controlled study to
evaluate the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of
NST-6179 in adult subjects with intestinal failure-associated liver disease (IFALD) receivin...
Age: 18 years - 66+
Gender: All
Testing Immunotherapy (Atezolizumab) With or Without Chemotherapy in Locoregional MSI-H/dMMR Gastric and Gastroesophageal Junction (GEJ) Cancer
This phase II trial compares atezolizumab in combination with chemotherapy (docetaxel, oxaliplatin, leucovorin calcium, fluorouracil, capecitabine) to atezolizumab alone for controlling the growth and/or spreading of the disease in patients with gastric or gastroesophag...
Age: 18 years - 66+
Gender: All
Methodology Issues in a Tailored Light Treatment for Persons With Dementia - Aim 2
Aim 2 will investigate the effect of 3 different light exposure lengths on sleep, mood and
agitation in persons with Alzheimer's disease. Participants will be randomly assigned to one
of three conditions of light exposure: 1) 2-h morning light exposure; 2) 4-h morni...
Age: 65 years - 66+
Gender: All
Outcome of Patients With Severe Functional TR According to Medical, Transcatheter or Surgical Treatment
Tricuspid regurgitation (TR) is a public health problem: moderate / severe TR are common,
especially in ageing populations, and affect 4% of the population >75 years old, totaling
approximately 1.6 million in the US and 3 million in Europe. TR is associated with an
...
Age: 18 years - 66+
Gender: All
Strategies and Treatments for Respiratory Infections &Amp; Viral Emergencies (STRIVE): Immune Modulation Strategy Trial
COVID-19 can trigger a dysregulated immune response, and previous studies have shown that
immune modulation can improve outcomes in hospitalized patients. This trial is designed to
determine whether intensification of immune modulation early in the course of the dis...
Age: 18 years - 66+
Gender: All
Efficacy, Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of BIA 28-6156 in GBA-PD
The purpose of this randomized, double-blind, placebo-controlled study is to assess the
efficacy of BIA 28-6156 over placebo in delaying clinical meaningful motor progression over
78 weeks in subjects with Parkinson's disease who have a pathogenic variant in the
g...
Age: 35 - 80 years
Gender: All
Study to Assess Adverse Events, Change in Disease Activity, and How Oral Upadacitinib Moves Through the Body of Pediatric Participants With Moderately to Severely Active Ulcerative Colitis.
Ulcerative colitis (UC) is a type of inflammatory bowel disease that causes inflammation and
bleeding from the lining of the rectum and colon (large intestine). This study will assess
how safe and effective Upadacitinib is in treating pediatric participants with UC....
Age: 2 - 17 years
Gender: All
The Effect of a Lighting Intervention on Sleep in Parkinson Disease
50 participants with Parkinson's disease will be recruited to complete actigraphy studies to
assess sleep disturbances. For this, participants will wear an Actigraph for seven days.
Thirty of these participants with sleep disturbance will go on to receive a tailored...
Age: 18 years - 66+
Gender: All
Lighting Intervention to Improve Sleep
50 participants with Parkinson's disease will be recruited to complete actigraphy studies to
assess sleep disturbances. For this, participants will wear an Actigraph for seven days.
Thirty of these participants with sleep disturbance, will go on to receive a tailore...
Age: 18 years - 66+
Gender: All
A Study to Investigate the Safety and Tolerability of Ziftomenib in Combination With Venetoclax/Azacitidine, Venetoclax, or 7+3 in Patients With AML
This Phase 1 study will assess the safety, tolerability, and preliminary antileukemic
activity of ziftomenib in combination with venetoclax and azacitidine (ven/aza), ven, and 7+3
for two different molecularly-defined arms, NPM1-m and KMT2A-r.
Age: 18 years - 66+
Gender: All
Study of Obeldesivir in Nonhospitalized Participants With COVID-19
The goal of this clinical study is to test if obeldesivir (formerly GS-5245) is safe and
effective for the treatment of coronavirus disease 2019 (COVID-19) in participants who have a
standard risk of developing severe illness. This study will also measure how much o...
Age: 12 - 64 years
Gender: All
Imaging Coronary Microvascular Dysfunction (CMD) Study
Angina is a common clinical symptom of ischemic heart disease, affecting up to 11 million
people in the United States alone, and 112 million people globally. Despite this, 4 in 10
patients undergoing elective coronary angiography for angina and ischemia do not have
...
Age: 18 years - 66+
Gender: All
Alzheimer's Disease Neuroimaging Initiative 4
Since its launch in 2004, the overarching aim of the Alzheimer's Disease Neuroimaging
Initiative (ADNI) Study has been to validate biomarkers for Alzheimer's disease (AD) clinical
trials. ADNI4 continues the previously funded ADNI1, ADNI-GO, ADNI2, and ADNI3 studies...
Age: 55 - 90 years
Gender: All
A Study of LOXO-435 in Participants With Cancer With a Change in a Gene Called FGFR3
The main purpose of this study is to learn more about the safety, side effects, and
effectiveness of LOXO-435. LOXO-435 may be used to treat cancer of the cells that line the
urinary system and other solid tumor cancers that have a change in a particular gene (known...
Age: 18 years - 66+
Gender: All