The Effect of a Lighting Intervention on Sleep in Parkinson Disease
50 participants with Parkinson's disease will be recruited to complete actigraphy studies to assess sleep disturbances. For this, participants will wear an Actigraph for seven days. Thirty of these participants with sleep disturbance will go on to receive a tailored lig...
Age: 18 years - 66+
Gender: All
Lighting Intervention to Improve Sleep
50 participants with Parkinson's disease will be recruited to complete actigraphy studies to assess sleep disturbances. For this, participants will wear an Actigraph for seven days. Thirty of these participants with sleep disturbance, will go on to receive a tailored li...
Age: 18 years - 66+
Gender: All
7T MRI for Light Therapy in Patients With Mild Cognitive Impairment and Mild AD
The purpose of this research study is to investigate the effect of a light treatment on
sleep, memory and brain function. In people with mild cognitive impairment (MCI) and
Alzheimer's disease, sleep-wake disturbance is evident in up to 60% of patients. This can be
...
Age: 50 - 85 years
Gender: All
Pembrolizumab for Advanced NSCLC and PS 2-3
This single center open-label trial will enroll a single cohort of patients with advanced non-small cell lung cancer (NSCLC) who are ineligible for treatment with curative intent due to 1) disease stage IV, or 2) inability to tolerate intensive surgery or chemo-radiatio...
Age: 18 years - 66+
Gender: All
Olpasiran Trials of Cardiovascular Events and Lipoprotein(a) Reduction (OCEAN(a)) - Outcomes Trial
The primary objective of this study is to compare the effect of treatment with olpasiran, to
placebo, on the risk for coronary heart disease death (CHD death), myocardial infarction, or
urgent coronary revascularization in participants with atherosclerotic cardiovas...
Age: 18 - 85 years
Gender: All
A Study to Evaluate Change in Disease Activity of Subcutaneous (SC) Epcoritamab Combined With Intravenous and Oral Rituximab, Cyclophosphamide, Doxorubicin Hydrochloride, Vincristine, and Prednisone (R-CHOP) or R-CHOP in Adult Participants With Newly Diagnosed Diffuse Large B-Cell Lymphoma (DLBCL)
B-cell Lymphoma is an aggressive and rare cancer of a type of immune cells (a white blood
cell responsible for fighting infections). The purpose of this study is to assess the change
in disease activity of epcoritamab when combined with intravenous and oral rituxima...
Age: 18 - 79 years
Gender: All
Sotagliflozin in Heart Failure With Preserved Ejection Fraction (HFpEF) Patients
The clinical benefits of the dual Sodium-Glucose cotransporter (SGLT) 1 and 2-inhibition have
recently been reported in two clinical trials. The SOLOIST reported the benefits of
sotagliflozin in Type-2 Diabetes Mellitus (T2DM) patients hospitalized for worsening of ...
Age: 18 years - 66+
Gender: All
Study of Tecovirimat for Human Monkeypox Virus
A5418 is a randomized, placebo-controlled, double-blind study to establish the efficacy of
tecovirimat for the treatment of people with laboratory-confirmed or presumptive HMPXV
disease.
Age: Birth - 66+
Gender: All
Cannabinoids for the Reduction of Inflammation and Sickle Cell Related Pain
A randomized, double blind, study of dronabinol as a palliative agent in the treatment of pain, inflammation, and other complications of sickle cell disease (SCD).
Age: 18 years - 66+
Gender: All
A Study to Evaluate the Efficacy, Safety, and Drug Levels of Oral Ozanimod in Pediatric Participants With Moderately to Severely Active Crohn's Disease With an Inadequate Response to Conventional Therapy
The purpose of this study is to evaluate the efficacy, safety, drug levels, and drug effects
of ozanimod in pediatric participants with moderately to severely active Crohn's Disease.
Age: 2 - 17 years
Gender: All
Longitudinal Endotyping Of Atopic Dermatitis Through Transcriptomic Skin Analysis
This is a multi-center, longitudinal study which will characterize the gene expression profiles and transcriptomic endotypes that underlie mild and moderate-severe Atopic dermatitis (AD) and will determine changes in these expression patterns and endotypes in response t...
Age: 6 years - 66+
Gender: All
DPCP to Treat Cutaneous Neurofibromas Associated With NF1
Neurofibromatosis type 1 (NF1) is the most common genetic tumor predisposition syndrome,
affecting up to 1 in 2500 individuals. Cutaneous neurofibromas are benign with self-limited
growth; however, tumor burden may be excessive, tumors do not regress, and they can b...
Age: 18 years - 66+
Gender: All
A Study to Assess if BIIB122 Tablets Are Safe and Can Slow Worsening of Early-Stage Parkinson's Disease in Participants With Specific LRRK2 Genetic Variants Between the Ages of 30 and 80 Using the Movement Disorder Society-Unified Parkinson's Disease Rating Scale
In this study, researchers will learn more about a study drug called BIIB122 in participants
with early-stage Parkinson's disease (PD). The study will focus on participants with a
specific genetic variant in their LRRK2 gene.
The main question researchers are tr...
Age: 30 - 80 years
Gender: All
Study of Subcutaneous Epcoritamab in Combination With Intravenous Rituximab and Oral Lenalidomide (R2) to Assess Adverse Events and Change in Disease Activity in Adult Participants With Follicular Lymphoma
Follicular Lymphoma (FL) is the second most common B-cell cancer and the most common type of
cancer of lymphocytes. Unfortunately, this disease is incurable with conventional treatment
and the disease recurs in almost all patients. This study will assess how safe an...
Age: 18 years - 66+
Gender: All
A Cross-sectional Study of Lipoprotein(a) Levels in Patients With Documented History of Atherosclerotic Cardiovascular Disease (ASCVD)
The purpose of this study is to characterize the distribution of lipoprotein(a) (Lp(a))
levels among participants with a history of ASCVD as defined by their medical history and is
2-fold:
- Evaluate the distribution of Lp(a) value in the overall participants wi...
Age: 18 - 85 years
Gender: All
A Study to Learn About The Study Medicine (PF-07038124) In Patients With Mild To Moderate Atopic Dermatitis Or Mild To Severe Plaque Psoriasis.
The purpose of this clinical trial is to learn about the safety, how well the study medicine
works, extent to which side effects can be tolerated, and how the study medicine is changed
and eliminated from your body after you apply it on your skin. The study medicine...
Age: 12 years - 66+
Gender: All
Human Epilepsy Project 3
By carrying a careful, large-scale and ambitious prospective study of a cohort of
participants with generalized epilepsy, the study team hopes to clarify the likelihood of
response and remission in this type of epilepsy, and try to explore the underlying biological
...
Age: 13 years - 66+
Gender: All
ScreenPlus: A Comprehensive, Flexible, Multi-disorder Newborn Screening Program
ScreenPlus is a consented, multi-disorder pilot newborn screening program implemented in conjunction with the New York State Newborn Screening Program that provides families the option to have their newborn(s) screened for a panel of additional conditions. The study has...
Age: Birth - 66+
Gender: All
Post-approval Study of Transcarotid Artery Revascularization in Standard Risk Patients With Significant Carotid Artery Disease
The study objective is to evaluate real world usage of the ENROUTE Transcarotid Stent when
used with the ENROUTE Transcarotid Neuroprotection System in patients at standard risk for
adverse events from carotid endarterectomy
Age: 18 - 79 years
Gender: All
A Double-blind Study to Investigate Efficacy and Safety of Buntanetap Compared With Placebo in Participants With Early PD
The purpose of this study is to measure safety and efficacy of buntanetap capsules compared
with placebo capsules in participants with early PD.
Study details include:
- The study duration will be up to 7-8 months.
- The double-blind treatment duration wil...
Age: 40 - 85 years
Gender: All