Adjunctive Cannabidiol for Recovery From Opioid Study
The long-term goal of the project is to determine whether cannabidiol (CBD) can reduce craving and relapse in individuals with opioid use disorder (OUD). The first phase of this project was an open cross-over design study in healthy individuals to confirm the safety and...
Age: 18 - 65 years
Gender: All
MAGIC Ruxolitinib for aGVHD
This clinical trial will study ruxolitinib-based treatment of acute
graft-versus-host-disease (GVHD) that developed following allogeneic hematopoietic cell
transplant. Acute GVHD occurs when donor cells attack the healthy tissue of the body. The
most common symptoms ...
Age: 18 years - 66+
Gender: All
Antithrombotic Activities of Sotagliflozin Vs. Empagliflozin
The availability of Sodium-glucose cotransporter-2 inhibitors (SGLT2-i) has dramatically
altered the management of heart failure (HF) patients, independently of their ejection
fraction and glycemic status. A meta-analysis of 57 studies comparing SGLT2-I monotherapy
v...
Age: 18 years - 66+
Gender: All
The Prevent Coronary Artery Disease Trial
Despite increasing evidence that exposure to cardiovascular risk factors (CVRF) at an early age increases the prevalence of subclinical atherosclerosis and is associated with a greater risk of cardiovascular events later in life, there is a lack of randomized trial evid...
Age: 30 - 50 years
Gender: All
REvascularization CHoices Among Under-Represented Groups Evaluation: The RECHARGE Trial - Women
This is a research study in women to compare the outcomes of two procedures that restore
blood flow to the arteries of the heart. In one procedure the blockages are ballooned and
then stented with a small wire mesh tube through a small incision in the wrist or the
gr...
Age: 18 years - 66+
Gender: All
REvascularization CHoices Among Under-Represented Groups Evaluation: The RECHARGE Trial - Minorities
This is a research study in minorities to compare the outcomes of two procedures that
restore blood flow to the arteries of the heart. In one procedure the blockages are
ballooned and then stented with a small wire mesh tube through a small incision in the
wrist or t...
Age: 18 years - 66+
Gender: All
Cannabidiol for Opioid Addiction
The long-term goal of the project is to determine whether cannabidiol (CBD) can reduce craving and relapse in individuals with opioid use disorder (OUD). The first phase of our project was an open cross-over design study in healthy individuals to confirm the safety and ...
Age: 18 - 65 years
Gender: All
Longitudinal Cortical Demyelination in Multiple Sclerosis and Related Disorders
In this protocol, a combination of MRI, blood, and cerebrospinal fluid (CSF) analysis
will be used to understand the natural history, underlying immunologic mechanisms, and
clinical implications of central nervous system (CNS) lesions, in particular lesions in
the ce...
Age: 18 years - 66+
Gender: All
Phase I Trial to Evaluate VLP Peanut in Healthy and Peanut Allergic Subjects
This phase I clinical trial is designed to evaluate the safety and tolerability of VLP
Peanut in healthy subjects and in subjects with peanut allergy (PA). This clinical trial
will evaluate the immunotoxicity profile of VLP Peanut in healthy subjects and assess the
i...
Age: 18 - 50 years
Gender: All
GAMBIT Task with PTSD and Healthy Control Participants
This is a pilot study of a digital training task called GAMBIT. This study will be the
first to examine potential relationships between GAMBIT task completion and brain circuit
flexibility, behavior, and symptoms in participants with PTSD.
Age: 18 - 55 years
Gender: All
The Role of 5-Aminolevulinic Acid Fluorescence-Guided Surgery in Head and Neck Cancers: a Pilot Trial
This study allows head and neck cancer surgeons to specifically visualize cancerous cells
apart from normal healthy tissue. 5-aminolevulinic acid (5-ALA) is a safe and effective
FDA-approved agent successfully used by neurosurgeons for FGS of different brain tumors
i...
Age: 18 - 80 years
Gender: All
Rhythmic Light Therapy for Alzheimer's Disease Patients
The investigator will investigate how light delivering 40 hertz (Hz) affects subjective sleep
and cognition in a controlled laboratory study. A lab study will allow the collection of
electroencephalogram (EEG) data, perform cognitive tests, and observe the response ...
Age: 55 years - 66+
Gender: All
Phase 1 Study to Evaluate Safety and Pharmacokinetics of COVID-HIGIV Administered as a Single Dose or a Repeat Dose in Healthy Adults
This study is designed to evaluate three dose levels of Anti-SARS-CoV-2 Immunoglobulin Intravenous (Human) (COVID-HIGIV) for safety and pharmacokinetics (PK) in healthy adults. Two cohorts of healthy adult subjects will be enrolled into the study, cohort A (single dose)...
Age: 18 - 60 years
Gender: All
PPMI Clinical - Establishing a Deeply Phenotyped PD Cohort
The Parkinson Progression Marker Initiative (PPMI) is a longitudinal, observational,
multi-center natural history study to assess progression of clinical features, digital
outcomes, and imaging, biologic and genetic markers of Parkinson's disease (PD)
progression in ...
Age: 30 years - 66+
Gender: All
Cellular Mechanisms Regulating Depot Differences in Subcutaneous Adipose Tissue in Women
Researchers at the Diabetes, Obesity and Metabolism Institute are seeking healthy volunteers between 18 and 40 years of age with apple- or pear- shaped body for a study on fat and health in women (please request for body shape image email). The study requires up to thre...
Age: 18 - 40 years
Gender: Female
Macular Vessel Density and Foveal Avascular Zone Changes in Exfoliation Glaucoma vs Primary Open Angle Glaucoma vs Exfoliation Syndrome: An Optical Coherence Tomography Angiography Study
Glaucoma is an eye disease that results in damage to cells in the back of the eye known as the retina and poses a major risk to global public health. Primary open angle glaucoma (POAG) is the most common type of glaucoma in the United States. Exfoliation syndrome (XFS) ...
Age: 40 - 90 years
Gender: All
Sensitivity and Specificity of the NOVA-VEP (FP) Fixed Protocol for Glaucoma Diagnosis
This study is utilizing electrophysiology, called Visual Evoked Potental (VEP) and pattern Electroretinography (ERG) to measure the electrical activity of the visual pathway. VEP measures the electrical activity of the entire vision system. When light enters the eye, it...
Age: 18 - 90 years
Gender: All
Examining Dose-Related Effects of Oxytocin on Social Cognition Across Populations
Social cognition impairment is critical to the pathology and morbidity of a number of
psychiatric disorders, including the schizophrenia spectrum, the autism spectrum and the
personality disorders, thus representing a dimension consistent with RDoC. As such, this
stu...
Age: 18 - 65 years
Gender: All