Cannabidiol for Opioid Addiction
The long-term goal of the project is to determine whether cannabidiol (CBD) can reduce craving and relapse in individuals with opioid use disorder (OUD). The first phase of our project was an open cross-over design study in healthy individuals to confirm the safety and ...
Age: 18 - 65 years
Gender: All
Longitudinal Cortical Demyelination in Multiple Sclerosis and Related Disorders
In this protocol, a combination of MRI, blood, and cerebrospinal fluid (CSF) analysis will be
used to understand the natural history, underlying immunologic mechanisms, and clinical
implications of central nervous system (CNS) lesions, in particular lesions in the c...
Age: 18 years - 66+
Gender: All
AMP SCZ® Observational Study: PREDICT-DPACC
The Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ) is a large international
collaboration to develop algorithms using a set of clinical and cognitive assessments,
multi-modal biomarkers, and clinical endpoints that can be used to predict the trajectori...
Age: 12 - 30 years
Gender: All
A Study to Learn About a Modified RNA Vaccine Against Shingles in Healthy Adults
The purpose of this clinical study is to learn about the safety, extent of the side effects
(reaction to vaccine), and immune response (your immune system's reaction) of the study
vaccine called Varicella Zoster Virus modRNA (VZV modRNA). We are seeking for healthy
...
Age: 50 - 69 years
Gender: All
Phase I Trial to Evaluate VLP Peanut in Healthy and Peanut Allergic Subjects
This phase I clinical trial is designed to evaluate the safety and tolerability of VLP Peanut
in healthy subjects and in subjects with peanut allergy (PA). This clinical trial will
evaluate the immunotoxicity profile of VLP Peanut in healthy subjects and assess the
...
Age: 18 - 50 years
Gender: All
GAMBIT Task With PTSD and Healthy Control Participants
This is a pilot study of a digital training task called GAMBIT. This study will be the first
to examine potential relationships between GAMBIT task completion and brain circuit
flexibility, behavior, and symptoms in participants with PTSD.
Age: 18 - 55 years
Gender: All
The Role of 5-Aminolevulinic Acid Fluorescence-Guided Surgery in Head and Neck Cancers: a Pilot Trial
This study allows head and neck cancer surgeons to specifically visualize cancerous cells
apart from normal healthy tissue. 5-aminolevulinic acid (5-ALA) is a safe and effective
FDA-approved agent successfully used by neurosurgeons for FGS of different brain tumors ...
Age: 18 - 80 years
Gender: All
Rhythmic Light Therapy for Alzheimer's Disease Patients
The investigator will investigate how light delivering 40 hertz (Hz) affects subjective sleep
and cognition in a controlled laboratory study. A lab study will allow the collection of
electroencephalogram (EEG) data, perform cognitive tests, and observe the response ...
Age: 55 years - 66+
Gender: All
Adipose Tissue Depots and Metabolism
Researchers at the Diabetes, Obesity and Metabolism Institute are seeking healthy volunteers between 18 and 65 years of age for a study on Fat and Health. The study requires up to three visits to the clinical research unit at Mount Sinai Morningside. Participants will d...
Age: 18 - 65 years
Gender: All
Phase 1 Study to Evaluate Safety and Pharmacokinetics of COVID-HIGIV Administered as a Single Dose or a Repeat Dose in Healthy Adults
This study is designed to evaluate three dose levels of Anti-SARS-CoV-2 Immunoglobulin Intravenous (Human) (COVID-HIGIV) for safety and pharmacokinetics (PK) in healthy adults. Two cohorts of healthy adult subjects will be enrolled into the study, cohort A (single dose)...
Age: 18 - 60 years
Gender: All
PPMI Clinical - Establishing a Deeply Phenotyped PD Cohort
The Parkinson Progression Marker Initiative (PPMI) is a longitudinal, observational,
multi-center natural history study to assess progression of clinical features, digital
outcomes, and imaging, biologic and genetic markers of Parkinson's disease (PD) progression
...
Age: 30 years - 66+
Gender: All
Real-time Biofeedback With 7-Tesla MRI for Treatment of Depression
Previous research has shown that modulation of a brain region in rodents, the ventral
tegmental area (VTA), improves depressive symptoms. Human research has also shown that VTA
self-modulation using 'biofeedback' is feasible and successful in healthy volunteers. Thi...
Age: 18 - 65 years
Gender: All
Cellular Mechanisms Regulating Depot Differences in Subcutaneous Adipose Tissue in Women
Researchers at the Diabetes, Obesity and Metabolism Institute are seeking healthy volunteers between 18 and 40 years of age with apple- or pear- shaped body for a study on fat and health in women (please request for body shape image email). The study requires up to thre...
Age: 18 - 40 years
Gender: Female
Macular Vessel Density and Foveal Avascular Zone Changes in Exfoliation Glaucoma vs Primary Open Angle Glaucoma vs Exfoliation Syndrome: An Optical Coherence Tomography Angiography Study
Glaucoma is an eye disease that results in damage to cells in the back of the eye known as the retina and poses a major risk to global public health. Primary open angle glaucoma (POAG) is the most common type of glaucoma in the United States. Exfoliation syndrome (XFS) ...
Age: 40 - 90 years
Gender: All
Sensitivity and Specificity of the NOVA-VEP (FP) Fixed Protocol for Glaucoma Diagnosis
This study is utilizing electrophysiology, called Visual Evoked Potental (VEP) and pattern Electroretinography (ERG) to measure the electrical activity of the visual pathway. VEP measures the electrical activity of the entire vision system. When light enters the eye, it...
Age: 18 - 90 years
Gender: All
Vaginal Microbiome Exposure and Immune Responses in C-section Infants
The purpose of this research study is to assess at how differences in the microbiome
(naturally occurring bacteria) of a baby may protect, or put a baby at risk, for allergic
problems. The microbiome refers to the thousands of bacteria and molds that live in and on
...
Age: 18 - 45 years
Gender: Female
Collection of Sputum and Labeling for Lung Cancer
The primary objective of this study is to compare Assay results to diagnoses determined by
currently accepted standards for lung cancer detection. This will be accomplished by analysis
of sputum samples from three cohorts including healthy Participants, high risk Pa...
Age: 21 years - 66+
Gender: All
The Effect of Oxytocin Administration on Interpersonal Cooperation in Borderline Personality Disorder Patients and Healthy Adults
The study will examine behavioral patterns and underlying neural correlates which distinguish
patients with borderline personality disorder (BPD) from healthy subjects as they participate
in a two-person trust game and will determine whether administration of intran...
Age: 18 - 55 years
Gender: All
Examining Dose-Related Effects of Oxytocin on Social Cognition Across Populations
Social cognition impairment is critical to the pathology and morbidity of a number of
psychiatric disorders, including the schizophrenia spectrum, the autism spectrum and the
personality disorders, thus representing a dimension consistent with RDoC. As such, this
stu...
Age: 18 - 65 years
Gender: All