Longitudinal Cortical Demyelination in Multiple Sclerosis and Related Disorders

ID#: NCT05982925

Age: 18 years - 66+

Gender: All

Healthy Subjects: Accepts Healthy Volunteers

Recruitment Status: Enrolling by invitation

Start Date: May 06, 2022

End Date: July 31, 2034

Summary: In this protocol, a combination of MRI, blood, and cerebrospinal fluid (CSF) analysis will be used to understand the natural history, underlying immunologic mechanisms, and clinical implications of central nervous system (CNS) lesions, in particular lesions in the cerebral cortex, in multiple sclerosis (MS) and other inflammatory and autoimmune disorders affecting the CNS. Patients with these disorders, as well as healthy controls, will undergo baseline clinical evaluation and testing, bloodwork, and MRI, with follow up clinical evaluation, bloodwork, and MRI at years 1, 3, and 6. Additional MRIs may be performed in patients with possible new lesion formation or to compare MRI techniques. Lumbar puncture will be performed on participants who are not currently being treated with disease modifying therapies and who are willing to undergo the procedure.
Eligibility:

Inclusion Criteria:

- 18 years old

- able to provide consent in English

- able to undergo MRI

Exclusion Criteria:

- contraindication to MRI

- pregnancy
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