Rhythmic Light Therapy for Alzheimer's Disease Patients

ID#: NCT05015478

Age: 55 years - 66+

Gender: All

Healthy Subjects: Accepts Healthy Volunteers

Study Phase: N/A

Recruitment Status: Recruiting

Start Date: January 10, 2022

End Date: January 01, 2023

Contact Information:
Barbara Plitnick, BSN
Mariana Figueiro, PhD
Summary: The investigator will investigate how light delivering 40 hertz (Hz) affects subjective sleep and cognition in a controlled laboratory study. A lab study will allow the collection of electroencephalogram (EEG) data, perform cognitive tests, and observe the response in those with mild cognitive impairment (MCI) compared to a healthy control group (HC). Participants will attend two study sessions over the course of two weeks. During both sessions, all participants will experience 10 minutes of a low-level light, followed by a data collection period which involves a sleepiness rating, an electroencephalogram (EEG) recording, and a computerized memory test. Participants will then experience either a RL or a placebo RL condition for one hour, after which there will be a second data collection.

Inclusion Criteria:

- Participants must be diagnosed with amnestic mild cognitive impairment or mild Alzheimer's disease, as defined by a Montreal Cognitive Assessment (MoCA) score between 17 and 25

- For the age-matched healthy controls, participants must not be diagnosed with mild cognitive impairment or Alzheimer's disease related dementias (MoCA score above 25).

- Participants must score a 5 or less in the Pittsburgh Sleep Quality Index (PSQI)

Exclusion Criteria:

- All participants must not be taking sleeping medication or oral melatonin

- Presence of another brain disease that fully explains the dementia (extensive brain vascular disease, Parkinson's disease, dementia with Lewy bodies, traumatic brain injury, or multiple sclerosis)

- residence in a skilled nursing facility or long-term care

- Major organ failure (e.g., kidney failure)

- Uncontrolled generalized disorders such as hypertension or diabetes

- Obstructing cataracts, macular degeneration, and blindness

- Severe sleep apnea or restless leg syndrome

- History of epilepsy