The Prevent Coronary Artery Disease Trial
Despite increasing evidence that exposure to cardiovascular risk factors (CVRF) at an early age increases the prevalence of subclinical atherosclerosis and is associated with a greater risk of cardiovascular events later in life, there is a lack of randomized trial evid...
Age: 30 - 50 years
Gender: All
Sirolimus Coated BALloon Versus Standard Balloon Angioplasty in The Treatment of Below The Knee Arterial Disease
This is a Pivotal, Prospective, randomised, two arm, placebo controlled, single-blind,
multicentre trial that will be conducted at approximately 70 sites; approx. 40 sites with
at least 50% of subjects will be recruited from USA and approx. 30 sites OUS - Singapore,
...
Age: 21 - 99 years
Gender: All
IMPRoving Outcomes in Vascular DisEase- Aortic Dissection
The goal of this clinical trial is to determine whether an upfront invasive strategy of
TEVAR plus medical therapy reduces the occurrence of a composite endpoint of all-cause
death or major aortic complications compared to an upfront conservative strategy of
medical ...
Age: 21 years - 66+
Gender: All
Cholesterol Lowering and Residual Risk in Diabetes, Type 1
This is a prospective, interventional, cohort study, meaning that researchers will follow
and observe a group of enrolled study participants over a period of time (one to two
months) to gather information and record any developments of the outcomes in question.
Thi...
Age: 18 - 89 years
Gender: All
The GORE® VIAFORT Vascular Stent Iliofemoral Study
This study is a prospective, non-randomized, multicenter, single-arm, clinical study to
evaluate the performance, safety and efficacy of the GORE® VIAFORT Vascular Stent for
treatment of symptomatic iliofemoral venous obstruction.
Age: 18 years - 66+
Gender: All
A Study Testing the Use of a Perivascular Sirolimus Formulation (Sirogen) in ESRD Patients Undergoing AV Fistula Surgery
The primary study objective is to evaluate the benefit of the Sirolimus eluting Collagen
implant (SeCI; Sirogen), a single dose prophylactic treatment delivered intraoperatively at
the time of surgical creation of an arteriovenous fistula for hemodialysis vascular a...
Age: 65 years - 66+
Gender: All
PROMISE III: Percutaneous Deep Vein Arterialization for the Treatment of Late-Stage Chronic Limb-Threatening Ischemia
A prospective, single-arm, multi-center study designed to gather additional information on
the LimFlow System.
Age: 18 - 95 years
Gender: All
Comparison of Anti-coagulation and Anti-Platelet Therapies for Intracranial Vascular Atherostenosis
The primary goal of the trial is to determine if the experimental arms (rivaroxaban or
ticagrelor or both) are superior to the clopidogrel arm for lowering the 1-year rate of
ischemic stroke, intracerebral hemorrhage, or vascular death.
Age: 30 years - 66+
Gender: All
Mammography and Breast Arterial Calcification: an Information-Sharing Trial
The purpose of this research study is to determine the potential benefits of adding
information on patients' breast arterial calcification (BAC) results to the standard
results letter women receive after mammography. In addition to looking for potential
breast cancer...
Age: 40 years - 66+
Gender: Female
Drug-Eluting Registry: Real-World Treatment of Lesions in the Peripheral Vasculature
The ELEGANCE Registry's objective is to collect Real-World Data (RWD), including
populations previously not represented in Peripheral Vascular Disease (PVD) trials,
health economics data, and to support the safe use of commercially available Boston
Scientific Corpora...
Age: 18 years - 66+
Gender: All
International Spontaneous Coronary Artery Dissection (SCAD) "iSCAD" Registry
The aim of "iSCAD," the International Spontaneous Coronary Artery Dissection (SCAD)
Registry, is to serve as an internationally collaborative, multicenter registry
coordinated by an experienced and centralized coordinating center in an effort to
increase the pace of ...
Age: 18 years - 66+
Gender: All
Macular Vessel Density and Foveal Avascular Zone Changes in Exfoliation Glaucoma vs Primary Open Angle Glaucoma vs Exfoliation Syndrome: An Optical Coherence Tomography Angiography Study
Glaucoma is an eye disease that results in damage to cells in the back of the eye known as the retina and poses a major risk to global public health. Primary open angle glaucoma (POAG) is the most common type of glaucoma in the United States. Exfoliation syndrome (XFS) ...
Age: 40 - 90 years
Gender: All
OT-58 as an Enzyme Therapy for Patients With Homocystinuria Caused by Cystathionine Beta-Synthase Deficiency
Homocystinuria caused by Cystathionine Beta-Synthase (CBS) Deficiency is a rare
autosomal-recessive metabolic condition characterized by an excess of homocysteine (Hcy) in
the plasma, tissues and urine. It is due to reduced or absent activity of the CBS enzyme, and
...
Age: 12 - 65 years
Gender: All
Study to Evaluate the Safety and Effectiveness of the CODMAN ENTERPRISE® Vascular Reconstruction Device
The purpose of this study is to demonstrate effectiveness and safety of the CODMAN
ENTERPRISE® Vascular Reconstruction Device and Delivery System.
Age: 21 - 70 years
Gender: All
Defining the Basis of Fibromuscular Dysplasia (FMD)
The purpose of this study has evolved and expanded since its inception. Originally the
intent was to establish the functional, molecular and genetic profile of fibroblasts from
Fibromuscular Dysplasia (FMD) patients as compared to carefully matched control subjects.
...
Age: 18 years - 66+
Gender: All
Discharge Educational Strategies for Reduction of Vascular Events
DESERVE is a discharge education study using health workers to enroll and randomly assign 800
subjects diagnosed with TIA, or mild stroke to either risk factor education or usual care.
Those patients assigned to education will receive stroke preparedness education plu...
Age: 18 years - 66+
Gender: All