A Clinical Study to Investigate the Efficacy and Safety of an Investigational Combination Therapy With BNT324 and BNT327 in Patients With Advanced Lung Cancer
This study aims to investigate the combination of BNT324, a B7-H3 antibody-drug conjugate
(ADC) with BNT327, a programmed death-ligand 1 (PD-L1) and vascular endothelial growth
factor (VEGF) bispecific antibody, in participants with advanced/metastatic or
relapsed/pr...
Age: 18 years - 66+
Gender: All
The Prevent Coronary Artery Disease Trial
Despite increasing evidence that exposure to cardiovascular risk factors (CVRF) at an
early age increases the prevalence of subclinical atherosclerosis and is associated with
a greater risk of cardiovascular events later in life, there is a lack of randomized
trial e...
Age: 30 - 50 years
Gender: All
The Prevent Coronary Artery Disease Trial
Despite increasing evidence that exposure to cardiovascular risk factors (CVRF) at an early age increases the prevalence of subclinical atherosclerosis and is associated with a greater risk of cardiovascular events later in life, there is a lack of randomized trial evid...
Age: 30 - 50 years
Gender: All
Amplitude Vascular Systems (AVS) Lithotripsy POWER PAD 2 Trial
POWER PAD 2 is a prospective, single-arm, multicenter, non-randomized clinical study
designed to demonstrate the safety and effectiveness of the Amplitude Vascular Systems
(AVS) Pulse Intravascular Lithotripsy™ (Pulse IVL™) System for treatment of calcified
(moderate...
Age: 18 years - 66+
Gender: All
Sirolimus Coated BALloon Versus Standard Balloon Angioplasty in The Treatment of Below The Knee Arterial Disease
This is a Pivotal, Prospective, randomised, two arm, placebo controlled, single-blind,
multicentre trial that will be conducted at approximately 70 sites; approx. 40 sites with
at least 50% of subjects will be recruited from USA and approx. 30 sites OUS - Singapore,
...
Age: 21 - 99 years
Gender: All
IMPRoving Outcomes in Vascular DisEase - Aortic Dissection
The goal of this clinical trial is to determine whether an upfront invasive strategy of
TEVAR plus medical therapy reduces the occurrence of a composite endpoint of all-cause
death or major aortic complications compared to an upfront conservative strategy of
medical ...
Age: 21 years - 66+
Gender: All
IMPRoving Outcomes in Vascular DisEase - Aortic Dissection
The goal of this clinical trial is to determine whether an upfront invasive strategy of
TEVAR plus medical therapy reduces the occurrence of a composite endpoint of all-cause
death or major aortic complications compared to an upfront conservative strategy of
medical ...
Age: 21 years - 66+
Gender: All
Cholesterol Lowering and Residual Risk in Diabetes, Type 1
This is a prospective, interventional, cohort study, meaning that researchers will follow
and observe a group of enrolled study participants over a period of time (one to two
months) to gather information and record any developments of the outcomes in question.
Thi...
Age: 18 - 89 years
Gender: All
Cholesterol Lowering and Residual Risk in Diabetes, Type 1
This is a prospective, interventional, cohort study, meaning that researchers will follow
and observe a group of enrolled study participants over a period of time (one to two
months) to gather information and record any developments of the outcomes in question.
Thi...
Age: 18 - 89 years
Gender: All
A Study Testing the Use of a Perivascular Sirolimus Formulation (Sirogen) in ESRD Patients Undergoing AV Fistula Surgery
The primary study objective is to evaluate the benefit of the Sirolimus eluting Collagen
implant (SeCI; Sirogen), a single dose prophylactic treatment delivered intraoperatively at
the time of surgical creation of an arteriovenous fistula for hemodialysis vascular a...
Age: 65 years - 66+
Gender: All
PROMISE III: Percutaneous Deep Vein Arterialization for the Treatment of Late-Stage Chronic Limb-Threatening Ischemia
A prospective, single-arm, multi-center study designed to gather additional information on
the LimFlow System.
Age: 18 - 95 years
Gender: All
Comparison of Anti-coagulation and Anti-Platelet Therapies for Intracranial Vascular Atherostenosis
The primary goal of the trial is to determine if the experimental arms (rivaroxaban or
ticagrelor or both) are superior to the clopidogrel arm for lowering the 1-year rate of
ischemic stroke, intracerebral hemorrhage, or vascular death.
Age: 30 years - 66+
Gender: All
Comparison of Anti-coagulation and Anti-Platelet Therapies for Intracranial Vascular Atherostenosis
The primary goal of the trial is to determine if the experimental arms (rivaroxaban or
ticagrelor or both) are superior to the clopidogrel arm for lowering the 1-year rate of
ischemic stroke, intracerebral hemorrhage, or vascular death.
Age: 30 years - 66+
Gender: All
Mammography and Breast Arterial Calcification: an Information-Sharing Trial
The purpose of this research study is to determine the potential benefits of adding
information on patients' breast arterial calcification (BAC) results to the standard
results letter women receive after mammography. In addition to looking for potential
breast cancer...
Age: 40 years - 66+
Gender: Female
Mammography and Breast Arterial Calcification: An Information-Sharing Trial
The purpose of this research study is to determine the potential benefits of adding
information on patients' breast arterial calcification (BAC) results to the standard
results letter women receive after mammography. In addition to looking for potential
breast cancer...
Age: 40 years - 66+
Gender: Female
Determinants of Incident Stroke Cognitive Outcomes and Vascular Effects on RecoverY
The overall goal of the DISCOVERY study is to better understand what factors contribute
to changes in cognitive (i.e., thinking and memory) abilities in patients who experienced
a stroke. The purpose of the study is to help doctors identify patients at risk for
demen...
Age: 18 years - 66+
Gender: All
Drug-Eluting Registry: Real-World Treatment of Lesions in the Peripheral Vasculature
The ELEGANCE Registry's objective is to collect Real-World Data (RWD), including
populations previously not represented in Peripheral Vascular Disease (PVD) trials,
health economics data, and to support the safe use of commercially available Boston
Scientific Corpora...
Age: 18 years - 66+
Gender: All
Drug-Eluting Registry: Real-World Treatment of Lesions in the Peripheral Vasculature
The ELEGANCE Registry's objective is to collect Real-World Data (RWD), including
populations previously not represented in Peripheral Vascular Disease (PVD) trials,
health economics data, and to support the safe use of commercially available Boston
Scientific Corpora...
Age: 18 years - 66+
Gender: All
International Spontaneous Coronary Artery Dissection (SCAD) "iSCAD" Registry
The aim of "iSCAD," the International Spontaneous Coronary Artery Dissection (SCAD)
Registry, is to serve as an internationally collaborative, multicenter registry
coordinated by an experienced and centralized coordinating center in an effort to
increase the pace of ...
Age: 18 years - 66+
Gender: All
Macular Vessel Density and Foveal Avascular Zone Changes in Exfoliation Glaucoma vs Primary Open Angle Glaucoma vs Exfoliation Syndrome: An Optical Coherence Tomography Angiography Study
Glaucoma is an eye disease that results in damage to cells in the back of the eye known as the retina and poses a major risk to global public health. Primary open angle glaucoma (POAG) is the most common type of glaucoma in the United States. Exfoliation syndrome (XFS) ...
Age: 40 - 90 years
Gender: All