SAFE Nerve Sparing Guided by Micro-ultrasound (MUS)
Robotic-assisted radical prostatectomy (RALP) has become the standard of care in the
management of localized prostate cancer. However, post-prostatectomy erectile dysfunction
(ED) and urinary incontinence still pose a challenge that adversely affects the patient's
qu...
Age: 18 years - 66+
Gender: Male
Testing the Addition of Docetaxel (Chemotherapy) to the Usual Treatment (Hormonal Therapy and Apalutamide) for Metastatic Prostate Cancer, ASPIRE Trial
This phase III trial compares the effect of adding docetaxel to hormonal therapy and apalutamide versus hormonal therapy and apalutamide alone in treating patients with prostate cancer that has spread from where it first started (primary site) to other places in the bod...
Age: 18 years - 66+
Gender: Male
A Clinical Study of Ifinatamab Deruxtecan (I-DXd) in People With Metastatic Prostate Cancer (MK-2400-001)
Researchers are looking for new ways to treat metastatic castration-resistant prostate
cancer (mCRPC). Researchers have designed a study medicine called ifinatamab deruxtecan
(also called I-DXd or MK-2400) to treat mCRPC. The goal of this study is to learn if
people ...
Age: 18 years - 66+
Gender: Male
A Study to Compare the Efficacy and Safety of BMS-986365 Versus the Investigator's Choice of Therapy in Participants With Metastatic Castration-resistant Prostate Cancer
The purpose of this study is to compare the efficacy and safety of BMS-986365 versus the
investigator's choice of therapy in participants with Metastatic Castration-resistant
Prostate Cancer.
Age: 18 years - 66+
Gender: Male
WATER IV Prostate Cancer
This is a multicenter, prospective, randomized clinical trial that aims to assess the
safety and efficacy of Aquablation Therapy in men with low-risk to intermediate to
high-risk localized prostate cancer who are candidates for, or have opted for,
prostatectomy. Part...
Age: 45 years - 66+
Gender: Male
Targeted Treatment for Metastatic Prostate Cancer, The PREDICT Trial
This phase II trial evaluates whether genetic testing in prostate cancer is helpful in
deciding which study treatment patients are assigned. Patient cancer tissue samples are
obtained from a previous surgery or biopsy procedure and tested for deoxyribonucleic acid
(D...
Age: 18 years - 66+
Gender: All
A Study of LY4052031 in Participants With Advanced or Metastatic Urothelial Cancer or Other Solid Tumors
The purpose of this study is to find out whether the study drug, LY4052031, is safe,
tolerable and effective in participants with advanced, or metastatic solid tumors
including urothelial cancer. The study is conducted in two parts - phase Ia
(dose-escalation, dose-o...
Age: 18 years - 66+
Gender: All
A Dose Finding Study of Debio 4228 in Participants With Advanced Prostate Cancer
The primary purpose of this study is to determine the pharmacokinetics (PK) and
pharmacodynamics (PD) of Debio 4228.
Age: 18 years - 66+
Gender: Male
Positron Emission Tomography Using 64Cu-SAR-bisPSMA in Participants With High-risk Prostate Cancer Prior to Radical Prostatectomy
The aim for this study is to assess the diagnostic performance of 64Cu-SAR-bisPSMA PET to detect regional nodal metastases.
Age: 18 years - 66+
Gender: Male
Precision-Based Genomics in Prostate Cancer
Background:
Prostate cancer is the most common cancer and the second leading cause of death in males
in the United States. Researchers want to find additional gene mutations that may
increase a man s risk for prostate cancer and may affect how aggressive the diseas...
Age: 18 years - 66+
Gender: Male
TTX-080 HLA-G Antagonist in Subjects With Advanced Cancers
TTX-080-001 is a Phase 1, open label, dose escalation and dose expansion clinical study
to determine the safety, tolerability, and recommended Phase 2 dose of TTX-080
monotherapy (HLA-G inhibitor) and in combination with either pembrolizumab (PD-1
inhibitor), cetuxim...
Age: 18 years - 66+
Gender: All
Upright MRI for Prostate Cancer Screening
This is an investigator initiated study to test the efficacy of an upright MRI (Magnetic Resonance Imaging) for the screening of prostate cancer. The purpose of this study is to compare Upright MRI as a technique to PSA (Prostate Specific Antigen) and current MRI imagin...
Age: 18 - 100 years
Gender: Male
A Study of Androgen Annihilation in High-Risk Biochemically Relapsed Prostate Cancer
This is a randomized, open-label, three-arm, phase 3 study in men with biochemically
recurrent prostate cancer and PSA doubling time ≤ 9 months at the time of study entry.
Age: 18 years - 66+
Gender: Male
Study of Nivolumab Plus Ipilimumab, Ipilimumab or Cabazitaxel in Men With Metastatic Castration-Resistant Prostate Cancer
The purpose of this study is to determine whether nivolumab plus ipilimumab has preliminary
evidence of safety and effectiveness in the treatment of participants with metastatic
castration-resistant prostate cancer who have progressed after prior docetaxel-containing
...
Age: 18 years - 66+
Gender: Male