Pilot Trial of Colchicine in Urothelial Cancer and Other Solid Tumors
This open-label, non-randomized study aims to determine the anti-inflammatory effect of colchicine on the reduction of peripheral blood CRP in patients with solid tumors or localized urothelial cancer. There are two cohorts, which will enroll separately and parallelly. ...
Age: 18 years - 66+
Gender: All
Thoracotomy Versus Thoracoscopic Management of Pulmonary Metastases in Patients With Osteosarcoma
This phase III trial compares the effect of open thoracic surgery (thoracotomy) to
thoracoscopic surgery (video-assisted thoracoscopic surgery or VATS) in treating patients
with osteosarcoma that has spread to the lung (pulmonary metastases). Open thoracic surgery
...
Age: Birth - 50 years
Gender: All
Rectal Spacer Hydrogel Before Radiation Therapy in Reducing Radiation Dose to the Rectum in Patients With Prostate Cancer
This phase II trial studies the effect of rectal spacer hydrogel before radiation therapy in reducing radiation dose to the rectum in patients with prostate cancer. Rectal spacer hydrogen is a soft gel material used to create a space between the rectum and prostate duri...
Age: 18 years - 66+
Gender: Male
Environmental Factors and Thyroid Cancer
Thyroid cancer incidence has been steadily increasing and has nearly tripled since the 1970's in the US and worldwide. Early detection of small, papillary thyroid cancers using high quality diagnostic imaging explains only about 50% of this increased incidence, suggesti...
Age: 18 years - 66+
Gender: All
The Role of 5-Aminolevulinic Acid Fluorescence-Guided Surgery in Head and Neck Cancers: a Pilot Trial
This study allows head and neck cancer surgeons to specifically visualize cancerous cells apart from normal healthy tissue. 5-aminolevulinic acid (5-ALA) is a safe and effective FDA-approved agent successfully used by neurosurgeons for FGS of different brain tumors is g...
Age: 18 - 80 years
Gender: All
Abemaciclib in Combination With Bicalutamide for Androgen Receptor-positive, HER2-negative Metastatic Breast Cancer
This is an open label multicenter, Phase IB/II Study of Abemaciclib in Combination with
Bicalutamide for Androgen Receptor-positive, HER2-negative Metastatic Breast Cancer
Age: 18 - 90 years
Gender: Female
Integrated Intervention for Breast Cancer Survivors With Diabetes
The purpose of this research study is to learn how therapy for breast cancer or DCIS/LCIS affects cognitive function and beliefs about cancer/DCIS/LCIS and diabetes (DM). For this portion of the study, the study team will integrate the information collected at previous ...
Age: 55 years - 66+
Gender: Female
Increasing Breast Cancer Screening in Chinese Immigrants
The long-term goal of this research is to increase breast cancer screening rates in NYC
Chinese immigrants. The researchers plan to accomplish this objective by developing and
testing a culturally- and linguistically-adapted Witness Project program for Chinese
imm...
Age: 40 years - 66+
Gender: Female
The Personal Patient Profile Decision Support for Patients With Bladder Cancer
There is a pressing need to develop a personalized, value-based decisional tool for bladder cancer patients undergoing radical cystectomy (bladder removal) and urinary diversion to help them with communication with the physicians, shared decision making, and preparation...
Age: 18 years - 66+
Gender: All
A Study of JNJ-75229414 for Metastatic Castration-resistant Prostate Cancer Participants
The purpose of this study is to determine recommended Phase 2 dose (RP2D) regimen(s) of
JNJ-75229414 in Part 1 (Dose Escalation and to determine safety at the RP2D regimen(s) in
Part 2 (Dose Expansion).
Age: 18 years - 66+
Gender: Male
The Safety and Tolerability of PGV001-based Personalized Multi-peptide Vaccines in the Adjuvant Setting.
This proof of concept study is designed to test the safety and tolerability of PGV001-based personalized multi-peptide vaccines in combination with CDX-301 in subjects with a history of aggressive prostate cancer, in the tumor free adjuvant setting.
Age: 18 years - 66+
Gender: Male
Mammography and Breast Arterial Calcification: An Information-Sharing Trial
The purpose of this research study is to determine the potential benefits of adding
information on patients' breast arterial calcification (BAC) results to the standard results
letter women receive after mammography. In addition to looking for potential breast cance...
Age: 40 years - 66+
Gender: Female
Pancreatic Cancer Early Detection Consortium
The purpose of the Pancreatic Cancer Early Detection (PRECEDE) Consortium is to conduct
research on multiple aspects of early detection and prevention of pancreatic ductal
adenocarcinoma (PDAC) by establishing a multisite cohort of individuals with family history
...
Age: 18 - 90 years
Gender: All
Therapy Adapted for High Risk and Low Risk HIV-Associated Anal Cancer
This phase II trial studies the side effects of chemotherapy and intensity modulated
radiation therapy in treating patients with low-risk HIV-associated anal cancer, and
nivolumab after standard of care chemotherapy and radiation therapy in treating patients with
...
Age: 18 years - 66+
Gender: All
A Study of Disitamab Vedotin in Subjects With HER2 Expressing Urothelial Carcinoma
This study is being done to see if a drug called disitamab vedotin works to treat HER2
expressing urothelial cancer. It will also test how safe the drug is for participants.
Participants will have cancer that has spread in the body near where it started (locally
...
Age: 18 years - 66+
Gender: All
A Study Evaluating the Efficacy and Safety of Adjuvant Atezolizumab or Placebo and Trastuzumab Emtansine for Participants With HER2-Positive Breast Cancer at High Risk of Recurrence Following Preoperative Therapy
This is a Phase III, two-arm, randomized, double-blind placebo-controlled study in
participants with HER2-positive primary breast cancer who have received preoperative
chemotherapy and HER2-directed therapy, including trastuzumab followed by surgery, with a
findin...
Age: 18 years - 66+
Gender: All
A Study to Evaluate the Safety and Efficacy of Oral APL-1202 in Combination With Tislelizumab Compared to Tislelizumab Alone as Neoadjuvant Therapy in Patients With Muscle Invasive Bladder Cancer
This trial is designed to evaluate the safety, efficacy, and biomarker response of APL-1202 in combination with tislelizumab as neoadjuvant therapy for patients with MIBC who are cisplatin ineligible or refuse cisplatin-based chemotherapy.
Age: 18 years - 66+
Gender: All
Impact of COVID-19 on GU Disease
The purpose of this research study is to identify patients with GU disease with active or past COVID-19 infection. Participants will be asked to: - Complete an Online COVID-19 Questionnaire. - Disclose if the patient has or had Genitourinary cancer or benign urologic co...
Age: 40 years - 66+
Gender: All
A Study of TNB-585 in Subjects With Metastatic Castrate-Resistant Prostate Carcinoma
This is a phase 1, open-label study evaluating the safety, clinical pharmacology and clinical
activity of TNB-585, a PSMA x CD3 T-cell engaging bispecific antibody, in subjects with
metastatic castrate-resistant prostate cancer (mCRPC) who have received 2 or more pr...
Age: 18 years - 66+
Gender: Male
AVB-S6-500 (Batiraxcept)/Placebo in Combination With Paclitaxel in Patients With Platinum-Resistant Recurrent Ovarian Cancer
This is a randomize, double-blind Phase 3 study to compare the efficacy and safety of
AVB-S6-500 in combination with paclitaxel (Pac) versus placebo in combination with Pac in
patients with platinum resistant recurrent ovarian cancer.
Age: 18 years - 66+
Gender: Female