MCG Discovery Study in Emergency Departments
This prospective discovery study is designed to demonstrate the feasibility of using an unshielded, mobile MCG device in an Emergency Department (ED) setting. The main question it aims to answer is whether interpretable data can be reliably collected as part of an ED wo...
Age: 18 years - 66+
Gender: All
A Study to Assess Luspatercept in Lower-risk Myelodysplastic Syndrome Participants
The purpose of this study is to evaluate the efficacy and safety of Luspatercept when
administered at the maximum approved dose in low-risk Myelodysplastic Syndrome participants
who require red blood cell transfusions.
Age: 18 years - 66+
Gender: All
RECOVER-NEURO: Platform Protocol to Measure the Effects of Cognitive Dysfunction Interventions on Long COVID Symptoms
This platform protocol is designed to be flexible so that it is suitable for a wide range of
settings within health care systems, for remote settings, and in community settings where it
can be integrated into COVID-19 programs and subsequent treatment plans.
Thi...
Age: 18 years - 66+
Gender: All
Ritlecitinib in CTCL
The purpose of this research study is to evaluate the effectiveness and safety of
Ritlecitinib in skin and blood in persons with Cutaneous T-Cell Lymphoma (CTCL). CTCL is a
rare type of cancer that starts in the white blood cells and eventually can result in rashes
...
Age: 18 years - 66+
Gender: All
A Study of GEn-1124 in Subjects With Acute Respiratory Distress Syndrome (ARDS)
GEn1E-1124-002 is a two-part Phase 2 study to evaluate the safety and tolerability of
GEn-1124 in subjects with ARDS. Treatment with IV infusion dosing within 48 hours of ARDS
diagnosis. Subjects will be given a second dose approximately 8 hours after the first dose...
Age: 18 - 80 years
Gender: All
Diuretics Alone vs. Aortix Endovascular Device for Acute Heart Failure
Aortix is a circulatory support device for chronic heart failure patients on medical management who have been hospitalized for acute decompensated heart failure (ADHF) and are resistant to diuretic therapy. Eligible ADHF patients with diuretic resistance (irrespective o...
Age: 21 years - 66+
Gender: All
The Role of the Gastrointestinal-associated Lymphoid Tissue in the Cure of HIV Infection
The objective of this study is to understand the effects of HIV cure strategies on the virus and immune cells that reside within the gastrointestinal tract. Subjects receiving therapies with the potential for HIV cure will undergo a colonoscopy to obtain gastrointestina...
Age: 18 - 75 years
Gender: All
Ecopipam Tablets to Study Tourette's Disorder in Children, Adolescents and Adults
This Phase 3 multicenter study evaluates the maintenance of efficacy, safety and tolerability
of ecopipam tablets in children, adolescents and adults in the treatment of Tourette's
Disorder (TD). The study includes an open-label period followed by double-blind,
pl...
Age: 6 years - 66+
Gender: All
DevRobust Treatment for Mal de Débarquement Syndrome
Mal de Débarquement Syndrome (MdDS) is an under-recognized balance disorder, which is
manifested by persistent false sensations of oscillatory self-motion (rocking/swaying) and/or
pulling in a specific direction (gravitational pull). Patients with MdDS typically exp...
Age: 18 - 78 years
Gender: All
DPCP to Treat Cutaneous Neurofibromas Associated With NF1
Neurofibromatosis type 1 (NF1) is the most common genetic tumor predisposition syndrome,
affecting up to 1 in 2500 individuals. Cutaneous neurofibromas are benign with self-limited
growth; however, tumor burden may be excessive, tumors do not regress, and they can b...
Age: 18 years - 66+
Gender: All
RNS System LGS Feasibility Study
To generate preliminary safety and effectiveness data for brain-responsive neurostimulation
of thalamocortical networks as an adjunctive therapy in reducing the frequency of generalized
seizures in individuals 12 years of age or older with Lennox Gastaut Syndrome (L...
Age: 15 years - 66+
Gender: All
Study of R289 in Patients With Lower-risk Myelodysplastic Syndromes (LR MDS)
Phase 1b Study of R289 in Patients with Lower-risk Myelodysplastic Syndromes (LR MDS)
Age: 18 years - 66+
Gender: All
Testing a Novel Data-to-Suppression (D2S) Intervention Strategy in the Ryan White HIV/AIDS Program
The Ryan White HIV/AIDS Program (RWHAP) for low-income people with HIV (PWH) is a key
resource for reducing HIV health disparities and scaling up evidence-based interventions. As
RWHAP serves >50% of US PWH, RWHAP outcomes are vital to achieving "getting-to-zero"/ E...
Age: Birth - 66+
Gender: All
An Oral GnRH Antagonist to Treat Mild Autonomous Cortisol Excess (MACE) Due to Adrenal Adenomas in Postmenopausal Women
The purpose of this research study is to determine if treatment with Elagolix will improve
body weight, waist circumference, muscle strength, cortisol secretion, blood glucose,
cholesterol, and bone quality as well as mood and quality of life in a female patient wit...
Age: Birth - 66+
Gender: Female
Open-label Extension Trial to Evaluate the Long-term Safety of Apraglutide in Short Bowel Syndrome.
The primary objective of the trial is to assess long-term safety and tolerability of
apraglutide in subjects with SBS-IF.
Age: 18 years - 66+
Gender: All
Fragile X Online Registry With Accessible Research Database (FORWARD)
FORWARD, the Fragile X Registry and Database, is the largest collection of clinical and demographic data of the Fragile X syndrome (FXS) population in the United States. FORWARD was created to improve the care and quality of life for those living with FXS. Information c...
Age: 0 - 99 years
Gender: All
Fragile X Spectrum Disorders Biorepository
The purpose of this study is to collect, store, and study blood samples from people with Fragile X Spectrum Disorders. The samples from this study will provide a research for researchers to conduct genetic and other studies. This information may be used to advance the m...
Age: 0 - 99 years
Gender: All
Clinical Study of Cannabidiol in Children, Adolescents, and Young Adults With Fragile X Syndrome
This is a randomized, double-blind, placebo-controlled, multiple-center study, to assess the
efficacy and safety of Cannabidiol administered as ZYN002 for the treatment of children,
adolescent, and young adult patients with Fragile X Syndrome (FXS). Eligible partici...
Age: 3 - 23 years
Gender: All
An Open-Label, Long-term Study of GFB-887 in Patients With Glomerular Kidney Diseases
This is an open-label Phase 2 study evaluating the long term safety and tolerability of
GFB-887 in patients with focal segmental glomerulosclerosis (FSGS), and treatment-resistant
minimal change disease (TR-MCD)
Age: 18 - 75 years
Gender: All
Study of Lenacapavir for HIV Pre-Exposure Prophylaxis in People Who Are at Risk for HIV Infection
The goal of this clinical study is to test how well the study drug, lenacapavir (LEN), works
in preventing the risk of HIV.
Age: 16 years - 66+
Gender: All