Testing a Novel Data-to-Suppression (D2S) Intervention Strategy in the Ryan White HIV/AIDS Program
The Ryan White HIV/AIDS Program (RWHAP) for low-income people with HIV (PWH) is a key
resource for reducing HIV health disparities and scaling up evidence-based interventions. As
RWHAP serves >50% of US PWH, RWHAP outcomes are vital to achieving "getting-to-zero"/ E...
Age: Birth - 66+
Gender: All
An Oral GnRH Antagonist to Treat Mild Autonomous Cortisol Excess (MACE) Due to Adrenal Adenomas in Postmenopausal Women
The purpose of this research study is to determine if treatment with Elagolix will improve body weight, waist circumference, muscle strength, cortisol secretion, blood glucose, cholesterol, and bone quality as well as mood and quality of life in a female patient with mi...
Age: Birth - 66+
Gender: Female
Fragile X Online Registry With Accessible Research Database (FORWARD)
FORWARD, the Fragile X Registry and Database, is the largest collection of clinical and demographic data of the Fragile X syndrome (FXS) population in the United States. FORWARD was created to improve the care and quality of life for those living with FXS. Information c...
Age: 0 - 99 years
Gender: All
Fragile X Spectrum Disorders Biorepository
The purpose of this study is to collect, store, and study blood samples from people with Fragile X Spectrum Disorders. The samples from this study will provide a research for researchers to conduct genetic and other studies. This information may be used to advance the m...
Age: 0 - 99 years
Gender: All
Clinical Study of Cannabidiol in Children and Adolescents With Fragile X Syndrome
This is a randomized, double-blind, placebo-controlled, multiple-center study, to assess the
efficacy and safety of Cannabidiol administered as ZYN002 for the treatment of children and
adolescent patients with Fragile X Syndrome (FXS). Eligible participants will par...
Age: 3 - 17 years
Gender: All
An Open-Label, Long-term Study of GFB-887 in Patients With Glomerular Kidney Diseases
This is an open-label Phase 2 study evaluating the long term safety and tolerability of
GFB-887 in patients with focal segmental glomerulosclerosis (FSGS), and treatment-resistant
minimal change disease (TR-MCD)
Age: 18 - 75 years
Gender: All
Phase 2 Study to Assess the Safety, PK, and PD in SBS-IF Subjects
This is a randomized, double-blind, placebo-controlled, proof-of-concept (PoC), Phase 2 study
to assess the safety, PK, and PD of SC administration of HM15912 in adult subjects with
SBS-associated intestinal failure (SBS-IF).
Age: 18 years - 66+
Gender: All
COVID19 SARS Vaccinations: Systemic Allergic Reactions to SARS-CoV-2 Vaccinations
Background: Allergic reactions have been reported to occur after vaccination with both the
Pfizer-BioNTech COVID-19 Vaccine and Moderna COVID-19 Vaccine. Allergic reactions range from
mild to severe and include life- threatening anaphylactic reactions, although no d...
Age: 12 years - 66+
Gender: All
Cardiovascular Analysis of PEM
The purpose of this study is to examine cardiopulmonary function in Chronic Fatigue Syndrome
(CFS) patients and determine how it relates to the common symptom of Post-exertional malaise
(PEM). Subjects will complete a maximal exercise test on 2 subsequent days. Tota...
Age: 25 - 60 years
Gender: All
A Study of Auxora in Patients With Acute Pancreatitis and Accompanying SIRS
Approximately 216 patients with acute pancreatitis and accompanying SIRS will be randomized
at approximately 30 sites. Patients will be randomly assigned to either Auxora at one of
three dose levels or one of three placebo volumes to maintain the double-blind. Study...
Age: 18 years - 66+
Gender: All
Trial to Evaluate Efficacy and Safety of Apraglutide in SBS-IF
The primary objective of the trial is the confirmation of the efficacy of apraglutide to
evaluate the efficacy of weekly subcutaneous apraglutide in reducing parenteral support
dependency.
Age: 18 years - 66+
Gender: All
Trial to Evaluate Efficacy and Safety of Apraglutide in SBS-IF
The primary objective of the trial is the confirmation of the efficacy of apraglutide to evaluate the efficacy of weekly subcutaneous apraglutide in reducing parenteral support dependency.
Age: 18 years - 66+
Gender: All
Pediatrics HOT COVID-19 Database in NY Tristate
New York City (NYC) has become the epicenter of the worldwide pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). By collecting and summarizing the experience with other major health care providers in the tristate (New York (NY), New Jersey ...
Age: Birth - 21 years
Gender: All
Low-Dose Ketamine in Children With ADNP Syndrome
This is a Phase 2A, single dose, open-label study to evaluate the safety, tolerability, and efficacy of a low-dose, 40-minute infusion into the veins (intravenous infusion or "IV") of ketamine in children with ADNP syndrome (Activity-Dependent Neuroprotective Protein). ...
Age: 5 - 12 years
Gender: All
A Study of TRPC5 Channel Inhibitor in Patients With Diabetic Nephropathy, Focal Segmental Glomerulosclerosis, and Treatment-Resistant Minimal Change Disease
This is a phase 2a study evaluating the safety and tolerability of multiple ascending doses
of GFB-887 in patients with diabetic nephropathy (DN), focal segmental glomerulosclerosis
(FSGS), and treatment-resistant minimal change disease (TR-MCD).
Age: 18 - 75 years
Gender: All
Magrolimab + Azacitidine Versus Azacitidine + Placebo in Untreated Participants With Myelodysplastic Syndrome (MDS)
The primary objective of this study is to evaluate the efficacy of magrolimab in combination
with azacitidine compared to that of azacitidine plus placebo in previously untreated
participants with intermediate/high/very high risk myelodysplastic syndrome (MDS) by Re...
Age: 18 years - 66+
Gender: All
Impact of Clinician Virtual Human Interaction Training in Emotional Self-Awareness on Patients Suicidal Ideation and Suicide Crisis Syndrome
Working with patients at risk for suicide is highly stressful for clinicians and often
elicits powerful negative emotional responses that may adversely affect suicidal outcomes. A
proposed explanation has been that negative emotional responses may result in less emp...
Age: 18 - 65 years
Gender: All
Ecopipam Tablets to Study Tourette Syndrome in Children and Adolescents - Open Label Extension
This study is an international, multicenter, open-label, long term extension study evaluating
the safety of ecopipam tablets for the treatment of children and adolescent subjects with
Tourette Syndrome.
Age: 6 - 18 years
Gender: All
A Dose-Ranging Study to Determine the Efficacy, Safety and Tolerability of AeroFact
The purpose of this two-part Phase 2 study is to assess the safety, tolerability and efficacy
of aerosolized SF-RI 1 (AeroFact) when delivered via nCPAP at two different doses.
Age: 26 - 31 weeks
Gender: All
A Dose-Ranging Study to Determine the Efficacy, Safety and Tolerability of AeroFact
The purpose of this two-part Phase 2 study is to assess the safety, tolerability and efficacy
of aerosolized SF-RI 1 (AeroFact) when delivered via nCPAP at two different doses.
Age: 26 - 31 weeks
Gender: All