Open-label Study of Cenobamate Monotherapy in Adult Subjects With Newly Diagnosed or Recurrent Partial-Onset Epilepsy
					Cenobamate (YKP3089) is a small molecule approved in the United States (US), Europe and
several other countries around the world for the treatment of Partial-Onset (focal)
seizures in adult subjects (≥18 years of age). In the US it is approved for use as
monotherapy,...
					
						
							
						
						
							
								
									
										Age: 18 - 74 years
									
								
								
									
										Gender: All
									
								
							 
						
					 
				
			
				
					The Computational and Neural Mechanisms Linking Decision-making and Memory in Humans
					Learning to make good decisions in the present, and accurately recalling events and
information from the past, are critical aspects of human cognition that are often
impaired in many psychiatric disorders. This project aims to identify the how the choices
individuals...
					
						
							
						
						
							
								
									
										Age: 18 - 65 years
									
								
								
									
										Gender: All
									
								
							 
						
					 
				
			
				
					The Computational and Neural Mechanisms Linking Decision-making and Memory in Humans
					Learning to make good decisions in the present, and accurately recalling events and
information from the past, are critical aspects of human cognition that are often
impaired in many psychiatric disorders. This project aims to identify the how the choices
individuals...
					
						
							
						
						
							
								
									
										Age: 18 - 65 years
									
								
								
									
										Gender: All
									
								
							 
						
					 
				
			
				
					Electrophysiological Read-Out of Interoceptive Processing
					Interoception, or sensation from inside the body, is involved in a variety of clinical
symptoms, such as tics, compulsions and negative mood. This study uses invasive
recordings of brain activity and brain stimulation to better understand basic neural
mechanisms of i...
					
						
							
						
						
							
								
									
										Age: 18 years - 66+
									
								
								
									
										Gender: All
									
								
							 
						
					 
				
			
				
					Human Epilepsy Project 3
					By carrying a careful, large-scale and ambitious prospective study of a cohort of
 participants with generalized epilepsy, the study team hopes to clarify the likelihood of
 response and remission in this type of epilepsy, and try to explore the underlying biological
...
					
						
							
						
						
							
								
									
										Age: 13 years - 66+
									
								
								
									
										Gender: All
									
								
							 
						
					 
				
			
				
					Invasive Decoding and Stimulation of Altered Reward Computations in Depression
					Novel invasive neurostimulation stimulation strategies through neurosurgical
interventions are emerging as a promising therapeutical strategy for major depressive
disorder. These have been applied mostly to the anterior cingulate cortex, but other
limbic brain region...
					
						
							
						
						
							
								
									
										Age: 18 - 80 years
									
								
								
									
										Gender: All
									
								
							 
						
					 
				
			
				
					The Efficacy of a Subanesthetic Doses of IV Ketamine in the Treatment Drug Resistant Epilepsy
					Ketamine is a medication that came into clinical practice in the 1960's. Ketamine is used
as an anesthetic and to provide pain relief. Recently, Ketamine was approved to treat
drug resistant depression using subanesthetic doses. In the hospital setting, intravenous
a...
					
						
							
						
						
							
								
									
										Age: 18 years - 66+
									
								
								
									
										Gender: All
									
								
							 
						
					 
				
			
				
					Biology of Juvenile Myoclonic Epilepsy
					The investigators are collecting genetic information through blood samples as well as
 clinical and EEG data from over 1000 people with Juvenile Myoclonic Epilepsy (JME) across the
 UK, Europe and North America. This study will draw on both existing and new samples fr...
					
						
							
						
						
							
								
									
										Age: 10 - 40 years
									
								
								
									
										Gender: All