Testing Higher Dose Radiation Therapy for Locally Advanced Pancreatic Cancer
This phase III trial compares the effect of dose-escalated radiation therapy to usual
care in patients with locally advanced unresectable pancreatic ductal adenocarcinoma who
have received an initial 4-6 months of chemotherapy. Usual care options include
additional c...
Age: 18 years - 66+
Gender: All
A Study of LY4052031 in Participants With Advanced or Metastatic Urothelial Cancer or Other Solid Tumors
The purpose of this study is to find out whether the study drug, LY4052031, is safe,
tolerable and effective in participants with advanced, or metastatic solid tumors
including urothelial cancer. The study is conducted in two parts - phase Ia
(dose-escalation, dose-o...
Age: 18 years - 66+
Gender: All
Modulation of the Gut Microbiome With Pembrolizumab Following Chemotherapy in Resectable Pancreatic Cancer
A multi-institutional, single arm pilot study of antibiotics and pembrolizumab, following
chemotherapy for the treatment of surgically resectable pancreatic cancer.
Age: 19 years - 66+
Gender: All
Modulation of the Gut Microbiome With Pembrolizumab Following Chemotherapy in Resectable Pancreatic Cancer
A multi-institutional, single arm pilot study of antibiotics and pembrolizumab, following
chemotherapy for the treatment of surgically resectable pancreatic cancer.
Age: 19 years - 66+
Gender: All
Pancreatic Cancer Early Detection Consortium
The purpose of the Pancreatic Cancer Early Detection (PRECEDE) Consortium is to conduct
research on multiple aspects of early detection and prevention of pancreatic ductal
adenocarcinoma (PDAC) by establishing a multisite cohort of individuals with family
history of ...
Age: 18 - 90 years
Gender: All
Pancreatic Cancer Early Detection Consortium
The purpose of the Pancreatic Cancer Early Detection (PRECEDE) Consortium is to conduct
research on multiple aspects of early detection and prevention of pancreatic ductal
adenocarcinoma (PDAC) by establishing a multisite cohort of individuals with family
history of ...
Age: 18 - 90 years
Gender: All
Testing the Addition of a New Anti-cancer Drug, M3814 (Peposertib), to the Usual Radiotherapy in Patients With Locally Advanced Pancreatic Cancer
This phase I/II trial studies the safety, side effects and best dose of M3814 and to see
how well it works when given together with radiation therapy in treating patients with
pancreatic cancer that has spread to nearby tissue or lymph nodes (locally advanced).
M3814...
Age: 18 years - 66+
Gender: All
Testing the Addition of a New Anti-cancer Drug, M3814 (Peposertib), to the Usual Radiotherapy in Patients With Locally Advanced Pancreatic Cancer
This phase I/II trial studies the safety, side effects and best dose of M3814 and to see
how well it works when given together with radiation therapy in treating patients with
pancreatic cancer that has spread to nearby tissue or lymph nodes (locally advanced).
M3814...
Age: 18 years - 66+
Gender: All
Testing the Addition of a New Anti-cancer Drug, M3814 (Peposertib), to the Usual Radiotherapy in Patients With Locally Advanced Pancreatic Cancer
This phase I/II trial studies the safety, side effects and best dose of M3814 and to see
how well it works when given together with radiation therapy in treating patients with
pancreatic cancer that has spread to nearby tissue or lymph nodes (locally advanced).
M3814...
Age: 18 years - 66+
Gender: All
Confocal Laser Endomicroscopy as an Imaging Biomarker for the Diagnosis of Pancreatic Cystic Lesions
The study schema is shown in Figure 4. (A) All patients referred to one of the
participating academic centers for EUS evaluation of the PCL will be enrolled in the
protocol if they satisfy inclusion criteria. Patient consent will be obtained during the
clinic visit o...
Age: 18 years - 66+
Gender: All
Celiac Plexus Radio-Surgery for Pain Management
Many cancer patients, especially those with pancreatic cancer, suffer from severe lower back / upper abdominal pain. This pain is often poorly managed with standard treatments; the doses of painkiller required often induce side effects, whereas nerve block procedures (w...
Age: 18 years - 66+
Gender: All
Pancreas Registry and High Risk Registry
The purpose of this study is to establish a registry of patients with pancreatic
diseases. Patients included in the registry may include those with: pancreatic cancer,
precancerous lesions of the pancreas, inflammatory lesions of the pancreas, cystic
lesions of the p...
Age: 18 years - 66+
Gender: All
Pancreas Registry and High Risk Registry
The purpose of this study is to establish a registry of patients with pancreatic
diseases. Patients included in the registry may include those with: pancreatic cancer,
precancerous lesions of the pancreas, inflammatory lesions of the pancreas, cystic
lesions of the p...
Age: 18 years - 66+
Gender: All