Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity
This study will examine if maridebart cafraglutide as an adjunct to standard of care will
lead to a reduction in heart failure (HF) events such as HF hospitalizations and urgent
HF visits, cardiovascular (CV) deaths and improvement in HF symptoms in participants with
...
Age: 18 - 99 years
Gender: All
Mirikizumab Administered at the Same Time as Tirzepatide in Adult Participants With Moderately to Severely Active Ulcerative Colitis and Obesity or Overweight: Phase 3b Study
The main purpose of this study is to show whether in these individuals, treatment with both mirikizumab and tirzepatide, compared with treatment with mirikizumab and placebo, leads to decrease or disappearance of UC symptoms, and loss of at least one-tenth of the overal...
Age: 18 - 70 years
Gender: All
The Effect of Retatrutide Once Weekly on Cardiovascular Outcomes and Kidney Outcomes in Adults Living With Obesity (TRIUMPH-Outcomes)
The main purpose of this study is to determine if retatrutide can significantly lower the incidence of serious heart-related complications or prevent the worsening of kidney function. The trial will enroll adults with body mass index 27 kg/m^2 or higher and Atherosclero...
Age: 45 years - 66+
Gender: All
DAYBREAK: A Study of Setmelanotide in Patients With Specific Gene Variants in the MC4R Pathway
A 2-stage (open-label run-in, followed by randomized, double-blind, placebo-controlled withdrawal) trial of setmelanotide in patients with obesity and specific gene defects variants in the melanocortin-4 receptor (MC4R) pathway.
Age: 6 - 65 years
Gender: All
Cellular Mechanisms Regulating Depot Differences in Subcutaneous Adipose Tissue in Women
Researchers at the Diabetes, Obesity and Metabolism Institute are seeking healthy volunteers between 18 and 40 years of age with apple- or pear- shaped body for a study on fat and health in women (please request for body shape image email). The study requires up to thre...
Age: 18 - 40 years
Gender: Female
Noom Coach for Bariatric Health
Mobile technologies/smartphone applications offer a means to effect behavior change without significant obstacles that typically limit implementation of empirically supported therapies (e.g., in-person sessions); however, rigorous research on apps is limited, and high-q...
Age: 18 - 60 years
Gender: All
P-15L Bone Graft in Transforaminal Lumbar Interbody Fusion With Instrumentation
The aim of this trial is to evaluate if P-15L bone graft (investigational device) is not inferior in effectiveness and safety to local autologous bone (and allograft where necessary) as an extender (control device) when applied in instrumented transforaminal lumbar inte...
Age: 22 - 80 years
Gender: All
Multi-level Supermarket Discounts of Fruits and Vegetables’ Impact on Intake and Health
The purpose of this study is to estimate how the price of fruits, vegetables, and calorie-free beverages influences food purchases, eating patterns, body weight, and overall health.
Age: 18 - 65 years
Gender: All