A Trial of Setmelanotide in Acquired Hypothalamic Obesity
The goal of this trial is to learn how well Setmelanotide works to improve weight reduction,
hunger, and quality of life in patients 4 years of age and older with acquired Hypothalamic
Obesity (HO). To determine how well setmelanotide works and how safe it is, patie...
Age: 4 years - 66+
Gender: All
EMANATE: A Study of Setmelanotide in Patients With Specific Gene Variants in the MC4R Pathway
The protocol describes a randomized, double-blind, placebo-controlled trial with independent
sub-studies of setmelanotide in patients with obesity and at least one of the specific gene
variants in the Melanocortin-4 Receptor pathway:
- POMC or PCSK1 (Sub-study 0...
Age: 6 - 65 years
Gender: All
Adipose Tissue Depots and Metabolism
Researchers at the Diabetes, Obesity and Metabolism Institute are seeking healthy volunteers between 18 and 65 years of age for a study on Fat and Health. The study requires up to three visits to the clinical research unit at Mount Sinai Morningside. Participants will d...
Age: 18 - 65 years
Gender: All
DAYBREAK: A Study of Setmelanotide in Patients With Specific Gene Variants in the MC4R Pathway
A 2-stage (open-label run-in, followed by randomized, double-blind, placebo-controlled withdrawal) trial of setmelanotide in patients with obesity and specific gene defects variants in the melanocortin-4 receptor (MC4R) pathway.
Age: 6 - 65 years
Gender: All
Cellular Mechanisms Regulating Depot Differences in Subcutaneous Adipose Tissue in Women
Researchers at the Diabetes, Obesity and Metabolism Institute are seeking healthy volunteers between 18 and 40 years of age with apple- or pear- shaped body for a study on fat and health in women (please request for body shape image email). The study requires up to thre...
Age: 18 - 40 years
Gender: Female
Noom Coach for Bariatric Health
Mobile technologies/smartphone applications offer a means to effect behavior change without significant obstacles that typically limit implementation of empirically supported therapies (e.g., in-person sessions); however, rigorous research on apps is limited, and high-q...
Age: 18 - 60 years
Gender: All
P-15L Bone Graft in Transforaminal Lumbar Interbody Fusion With Instrumentation
The aim of this trial is to evaluate if P-15L bone graft (investigational device) is not inferior in effectiveness and safety to local autologous bone (and allograft where necessary) as an extender (control device) when applied in instrumented transforaminal lumbar inte...
Age: 22 - 80 years
Gender: All
Multi-level Supermarket Discounts of Fruits and Vegetables’ Impact on Intake and Health
The purpose of this study is to estimate how the price of fruits, vegetables, and calorie-free beverages influences food purchases, eating patterns, body weight, and overall health.
Age: 18 - 65 years
Gender: All