A Study to Assess BMS-986453 in Participants With Relapsed and/or Refractory Multiple Myeloma
Study Phase: Phase 1
Recruitment Status: Recruiting
Start Date: January 23, 2024
End Date: May 02, 2030
BMS Clinical Trials Contact Center www.BMSClinicalTrials.com
855-907-3286
855-907-3286
First line of the email MUST contain NCT # and Site #.
Inclusion Criteria:
- Participants must have a diagnosis of multiple myeloma with relapsed and/or refractory disease.
- Participants must have confirmed progressive disease on or within 12 months (measured from the last dose) of completing treatment with the last anti-myeloma treatment regimen before study entry.
- Participants in Part A and Part B Cohort 1 and in Part B Cohort 2 must have relapsed/refractory multiple myeloma and received previous antimyeloma therapy, including a proteasome inhibitor and an immunomodulatory agent.
- Participants must have an Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1.
- Participants must have adequate organ function.
Exclusion Criteria:
- Participants must not have any known active or history of central nervous system (CNS) involvement of multiple myeloma.
- Participants must not have active or history of plasma cell leukemia, Waldenstrom's macroglobulinemia, POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, skin changes) syndrome, or clinically significant amyloidosis.
- Participants must not have a history or presence of clinically significant CNS pathology such as seizure disorder, aphasia, stroke, severe brain injury, dementia, Parkinson's disease, or cerebellar disease, or presence of clinically active psychosis.
- Other protocol-defined inclusion/exclusion criteria apply.
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Conditions:
- Multiple Myeloma