Influence of Cooling Duration on Efficacy in Cardiac Arrest Patients

ID#: NCT04217551

Age: 18 years - 66+

Gender: All

Healthy Subjects: No

Study Phase: N/A

Recruitment Status: Recruiting

Start Date: May 18, 2020

End Date: August 31, 2028

Contact Information:
William Meurer
734-232-2142
Nia Bozeman
734-620-7612
Summary: A multicenter, randomized, adaptive allocation clinical trial to determine if increasing durations of induced hypothermia are associated with an increasing rate of good neurological outcomes and to identify the optimal duration of induced hypothermia for neuroprotection in comatose survivors of cardiac arrest.
Eligibility:

Inclusion Criteria:

- Coma after resuscitation from out of hospital cardiac arrest

- Cooled to <34 deg C with 240 minutes of cardiac arrest

- Definitive temperature control applied

- Age ≥ 18 years

- Informed consent from legal authorized representative (LAR) including intent to maintain life support for 96 hours

- Enrollment within 6 hours of initiation of cooling

Exclusion Criteria:

- Hemodynamic instability

- Pre-existing neurological disability or condition that confounds outcome determination

- Pre-existing terminal illness, unlikely to survive to outcome determination

- Planned early withdrawal of life support

- Presumed sepsis as etiology of arrest

- Prisoner
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