DCIS: RECAST Trial Ductal Carcinoma In Situ: Re-Evaluating Conditions for Active Surveillance Suitability as Treatment

ID#: NCT06075953

Age: 18 years - 66+

Gender: Female

Healthy Subjects: No

Study Phase: Phase 2

Recruitment Status: Recruiting

Start Date: February 14, 2024

End Date: November 01, 2033

Contact Information:
Kim Nelson, RN
+1 (855) 866-0505
Maria Pitsiouni, PhD
+1 (888) 343-9922
Summary: The goal of this trial is to see if active surveillance monitoring and hormonal therapy in patients diagnosed with ductal cell carcinoma in situ (DCIS), an early stage of breast cancer, can be an effective management of the disease. Participants will be asked to receive control hormonal therapy or an investigational hormonal therapy treatment. Participants will be asked to return for evaluation with MRI at three months and six months. Depending on the evaluation participants will have the option to continue on the treatment. If the evaluation suggests surgery is recommended, the participant will discontinue the study treatment and will undergo surgery. In addition to the treatment and MRI evaluation, participants will be asked to provide blood sample to understand their immune status, provide saliva sample for genetic testing, provide the study with a portion of the tissue or slides generated from tissue removed during surgery performed as part of their standard of care.
Eligibility:

Inclusion Criteria:

- Female, at least 18 years old

- previous diagnosis of Hormone Receptor positive (HR+) DCIS (at least 50% ER or PR and 2+; biopsy will have been performed previously at diagnosis) with or without microinvasion

- Informed consent provided by the patient

- Willingness and ability to provide tumor samples for research

Exclusion Criteria:

- Pregnant or actively breastfeeding women (must be documented by a pregnancy test during screening)

- History of allergic reactions attributed to compounds of similar chemical or biologic composition to study agent based on review of the medical record and patient history.

- Invasive carcinoma or identification of a mass on MRI that is subsequently biopsied and found to be invasive cancer

- Co-enrollment in clinical trials of pharmacologic agents requiring an Investigational new Drug Appilcation (IND)

- Ongoing treatment for DCIS other than what is specified in this protocol

- Uncontrolled intercurrent illness, including psychiatric conditions, that would limit compliance with study requirements.

- Medical history or ongoing gastrointestinal disorders potentially affecting the absorption of investigational agent and/or tamoxifen. Participants unable to swallow normally or unable to take tablets and capsules. Predictable poor compliance to oral treatment. Active inflammatory bowel disease or chronic diarrhea, known active hepatitis A/B/C*, hepatic cirrhosis, short bowel syndrome, or any upper gastrointestinal surgery including gastric resection or banding procedures.
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