Arthritis - psoriatic; Psoriasis - psoriatic arthritis; Spondyloarthritis - psoriatic arthritis; PsA
Psoriasis is a common skin problem that causes red patches on the body. It is an ongoing (chronic) inflammatory condition. This condition occurs in about 7 to 42 percent people with psoriasis. Nail psoriasis is linked to psoriatic arthritis.
In most cases, psoriasis comes before the arthritis.
The cause of psoriatic arthritis is not known. Genes, immune system, and environmental factors may play a role. It is likely that the skin and joint diseases may have similar causes. However, they may not occur together.
Psoriasis is a common skin condition that causes skin redness and irritation. Most people with psoriasis have thick, red skin with flaky, silver-white patches called scales. Psoriasis may affect you at any age, but it usually begins between the ages of 15 and 35. You can't spread this disorder to others, but it does seem to be passed down through families. We think it probably occurs when your immune system mistakes healthy cells for dangerous substances. Skin cells grow deep in your skin, normally rising to the surface about once a month. But, in people with psoriasis, this process occurs too fast, usually happening in only about 2 weeks, and dead skin cells build up on your skin's surface. Many factors can trigger psoriasis, or make it more difficult to treat, including bacterial or viral infections, dry air or skin, injuries to your skin, some medications, stress, too much or too little sunlight, and even too much alcohol. In general, psoriasis may be very bad in people who have a weakened immune system. Psoriasis can appear suddenly or it can appear slowly. Often, it goes away and then flares up again, time after time. If you have psoriasis, you'll probably have irritated patches of skin on your body, often on your elbows and knees. But it can show up anywhere on your body, even your scalp. The skin patches may be itchy, dry and covered with silver, flaky scales. They may be pink in color and raised and thick. So, what do you do about psoriasis? Well, your doctor will need to look at your skin to make a diagnosis. Sometimes the doctor will take a skin sample, or a biopsy, to rule out other possible problems. Your treatment will focus on controlling your symptoms and preventing infections. In general, you have three options topical medications like lotions or creams, pills or injections that affect your whole body, and therapy that uses light to treat psoriasis. But most people tend to use creams or ointments they place directly on their skin. Psoriasis is a life-long condition you can control with treatment. It may go away for a long time and then suddenly return. Fortunately, with the right treatment, it usually does not affect your general physical health.
The arthritis may be mild and involve only a few joints. The joints at the end of the fingers or toes may be more affected.
In some people, the disease may be severe and affect many joints, including the spine. Symptoms in the spine include stiffness and pain. They most often occur in the lower spine and sacrum.
Some people with psoriatic arthritis may have inflammation of the eyes.
Most of the time, people with psoriatic arthritis have the skin and nail changes of psoriasis. Often, the skin gets worse at the same time as the arthritis.
Exams and Tests
During a physical exam, the health care provider will look for:
- Joint swelling
- Skin patches (psoriasis) and pitting in the nails
- Inflammation in the eyes
Joint x-rays may be done.
There are no specific blood tests for psoriatic arthritis or for psoriasis. The provider may test for a gene called HLA-B27.
People with involvement of the back are more likely to have HLA-B27.
Your provider may give nonsteroidal anti-inflammatory drugs (NSAIDs) to reduce pain and swelling of the joints.
Arthritis that does not improve with NSAIDs will need to be treated with medicines called disease-modifying antirheumatic drugs (DMARDs). These include:
Apremilast (Otezla) is another medicine used for the treatment of psoriatic arthritis.
New biologic medicines are being widely used for progressive psoriatic arthritis. These medicines block an inflammatory protein called tumor necrosis factor (TNF). These are given by injection and include:
- Adalimumab (Humira)
- Certolizumab (Cimzia)
- Etanercept (Enbrel)
- Golimumab (Simponi)
- Infliximab (Remicade)
Other new biologic medicines are available to treat growing psoriatic arthritis. These medicines are also given by injection and include:
- Secukinumab (Cosentyx)
- Ixekizumab (Taltz)
- Ustekinumab (Stelara)
- Abatacept (Orencia)
Very painful joints may be treated with steroid injection. These are used when only one or a few joints are involved.
In rare cases, surgery may be needed to repair or replace damaged joints.
People with inflammation of the eye should see an ophthalmologist.
Your provider may suggest a mix of rest and exercise. Physical therapy may help increase joint movement. You may also use heat and cold therapy.
The disease is often mild and affects only a few joints. In some people, very bad psoriatic arthritis may cause deformities in the hands, feet, and spine.
Early treatment can ease pain and prevent joint damage, even in very bad cases.
When to Contact a Medical Professional
Call your provider if you develop symptoms of arthritis along with psoriasis.
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FitzGerald O, Elmamoun M. Psoriatic arthritis. In: Firestein GS, Budd RC, Gabriel SE, McInnes IB, O'Dell JR, eds. Kelley and Firestein's Textbook of Rheumatology. 10th ed. Philadelphia, PA: Elsevier Saunders; 2017:chap 77.
Smolen JS, Schöls M, Braun J, et al. Treating axial spondyloarthritis and peripheral spondyloarthritis, especially psoriatic arthritis, to target: 2017 update of recommendations by an international task force. Ann Rheum Dis. 2018;77(1):3-17. PMID: 28684559
Veale DJ, Orr C. Management of psoriatic arthritis. In: Hochberg MC, Gravallese EM, Silman AJ, Smolen JS, Weinblatt ME, Weisman MH, eds. Rheumatology. 7th ed. Philadelphia, PA: Elsevier; 2019:chap 131.
Last reviewed on: 1/29/2018
Reviewed by: Gordon A. Starkebaum, MD, ABIM Board Certified in Rheumatology, Seattle, WA. Internal review and update on 03/28/2019 by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.