Transcranial Magnetic Stimulation in Misophonia

ID#: NCT06960083

Age: 18 - 55 years

Gender: All

Healthy Subjects: No

Study Phase: N/A

Recruitment Status: Recruiting

Start Date: September 02, 2025

End Date: June 30, 2026

Contact Information:
Shama Patel
347-670-4878
Parul Jain, PhD
212-824-8992
Summary: The purpose of the project is to assess the efficacy of parietal transcranial magnetic stimulation in misophonia. N=60 participants will undergo two transcranial magnetic stimulation sessions: one inhibitory and another excitatory. During both sessions, the parietal region will be stimulated. Participants will perform computerized tasks immediately before and after the stimulation, while EEG, heart rate, and skin temperature will be recorded. These recordings will be used to assess if TMS can be used to improve tolerance to misophonia triggers.
Eligibility:

Inclusion Criteria:

- Hypersensitive to presence of a specific sound, which may be accompanied by irritation, anger/outbursts, or fear.

- Must be between the ages of 18

- 55.

- Must be fluent in English since the study's instructions, surveys, and tasks will be in English.

Exclusion Criteria:

- Epilepsy or previous episode of convulsion or seizure.

- Previous episode of fainting spell or syncope.

- Head trauma.

- Hearing problems.

- Cochlear implant.

- Metal in the brain, skull, or anywhere else in the body (e.g., splinters, fragments, clips, etc.).

- Implanted neurostimulator (e.g., DBS, epidural/subdural, VNS).

- Presence of cardiac pacemaker or intracardiac lines.

- Presence of medication infusion device.

- Use of pro-convulsant or epileptogenic medications.

- Pregnancy. The risks associated with TMS exposure during gestation have not been studied extensively. We wish to safeguard the health of potential participants and their children.

- Lactation. The risks associated with TMS during lactation and its effects on infant development have not been studied. We wish to safeguard the health of potential participants and their children.

- Presence of Mania, Psychosis, Antisocial Personality Disorder, Borderline Personality Disorder, and Suicidal Ideation.
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