A Study of the MIND Diet for Persons With Multiple Sclerosis

This study will assess the impact of a MIND (Mediterranean-DASH Intervention for Neurodegenerative Delay) diet on brain health and MS symptoms. Participants will be randomly assigned to one of two arms: the diet intervention arm or the "continue current diet"/control arm. Participants randomized to the dietary intervention arm will change their diet to follow a MIND dietary pattern for one year; diet-related education and programming is provided to support this change. Participants randomized to the continue/control arm will be asked to continue their current dietary habits, without major change for one year; multiple sclerosis (MS) MS-related related education and programming (unrelated to diet) is provided. All participants will be asked to provide blood & stool samples and to complete online questionnaires & three in-person assessments.

Inclusion Criteria:

- Ages 18-70 years, inclusive

- MS diagnosis, on any treatment (including no treatment)

- MIND diet score of ≤8 at baseline

- NfL parameters determined by age

Exclusion Criteria:

- Diagnosis of an additional neurodegenerative disease (e.g. Alzheimer's) or other serious neurological condition (e.g. stroke)

- Current serious medical condition that could impact the ability to participate or influence study results (e.g. cancer, HIV)

- Pregnancy/planning during study period

Conditions:
• Multiple Sclerosis