DBS for TRD With the Medtronic Percept PC
Of the estimated 30 million Americans who suffer from Major Depressive Disorder, approximately 10% are considered treatment resistant. Deep brain stimulation (DBS) to a region of the brain called the subcallosal cingulate (SCC) is an emerging strategy for treatment resi...
Age: 25 - 70 years
Gender: All
Invasive Decoding and Stimulation of Altered Reward Computations in Depression
Novel invasive neurostimulation stimulation strategies through neurosurgical interventions are emerging as a promising therapeutical strategy for major depressive disorder. These have been applied mostly to the anterior cingulate cortex, but other limbic brain regions h...
Age: 18 - 80 years
Gender: All
Targeting IL-17A for Treatment-Resistant Depression
The proposed study aims to test ixekizumab, a monoclonal antibody (mAb) against interleukin 17A (IL-17A), in patients with treatment-resistant depression (TRD).
Age: 18 - 65 years
Gender: All
XEN1101 for Major Depressive Disorder
This project is designed to examine the neuronal KCNQ2/3 potassium (K+) channel subtype as a
novel treatment target for mood disorders through the administration of the KCNQ-selective
channel opener XEN1101 (Xenon Pharmaceuticals).
Age: 18 - 65 years
Gender: All
Real-time Biofeedback With 7-Tesla MRI for Treatment of Depression
Previous research has shown that modulation of a brain region in rodents, the ventral
tegmental area (VTA), improves depressive symptoms. Human research has also shown that VTA
self-modulation using 'biofeedback' is feasible and successful in healthy volunteers. Thi...
Age: 18 - 65 years
Gender: All
ELEKT-D: Electroconvulsive Therapy (ECT) vs. Ketamine in Patients With Treatment Resistant Depression (TRD)
The goal of the study is to conduct a comparative randomized trial of electroconvulsive
therapy (ECT) vs. ketamine for patients with treatment resistant depression (TRD) in a real
world setting with patient reported outcomes as primary and secondary outcome measures...
Age: 21 - 75 years
Gender: All