Precision Analytic Research Methods in OCD

ID#: NCT07011901

Age: 18 - 55 years

Gender: All

Healthy Subjects: Accepts Healthy Volunteers

Study Phase: N/A

Recruitment Status: Recruiting

Start Date: July 09, 2025

End Date: March 31, 2030

Contact Information:
Amy Rapp, Ph.D.
212-241-5288
Summary: Psychiatric disorders characterized by compulsivity, such as obsessive-compulsive disorder (OCD), result in considerable functional impairment and many individuals do not respond to gold-standard treatments. Compulsivity has long been thought to occur due to exaggerated habits and reduced goal-directed control, although more recently, this conceptualization of compulsivity as an imbalance of two cognitive systems has been challenged as overly narrow. This study will recruit 100 individuals (50 adults diagnosed with OCD, 50 healthy controls) and leverage the measurement precision offered by theory-driven computational modeling in combination with electroencephalogram (EEG) to go beyond this binary theory of compulsivity, revealing how more complex interactions of neurocognitive subcomponents contribute to compulsivity-information that could ultimately lead to improved treatment personalization and clinical outcomes.
Eligibility:

Inclusion Criteria: Participants must be:

- between the ages 18-55 years old

- English-speaking

- right-handed

- able to provide consent

Exclusion Criteria: Individuals diagnosed with OCD will be excluded if:

- they meet diagnostic criteria for certain other psychiatric disorders

- are taking psychiatric medication or have received behavioral treatment for OCD within a certain timeframe

- if it is unsafe for them to participate in research Healthy control participants will be excluded if:

- they have a current psychiatric disorder

- a lifetime history of certain psychiatric disorders

- are taking psychiatric medication or have in the past

- have a parent or sibling who has been diagnosed with OCD

- if it is unsafe for them to participate in research
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