MINDS Imaging Ancillary Study

ID#: NCT05270356

Age: 18 - 30 years

Gender: All

Healthy Subjects: No

Recruitment Status: Enrolling by invitation

Start Date: May 27, 2021

End Date: March 01, 2025

Summary: This study is an ancillary study to the NHLBI-funded Pediatric Heart Network (PHN) "Multi-Institutional Neurocognitive Discovery Study" (MINDS) in Adult Congenital Heart Disease (ACHD). The MINDS-ACHD" study will recruit 500 complex CHD patients between18-30 years old. The investigators propose to quantitate multi-modal neuroimaging biomarkers (brain injury, structure and physiology) which are not only important components of brain and cognitive reserve but can be predictive of neurocognitive decline and early onset of dementia in the aging non-CHD population.
Eligibility:

Inclusion Criteria: • Participation in and completion of MINDS parent study procedures. The inclusion criteria for the MINDS parent study consists of ACHD patients aged 18

- 30 years with moderate and severely complex CHD.

Exclusion Criteria:

- Individuals with mild complexity lesions;

- Individuals with MRI contraindications will be excluded from study participation. Contraindications include, but are not limited, to:

- Pregnancy or breast feeding

- Claustrophobia or inability to lie still for an extended period

- Implantable device (i.e., pacemaker; defibrillator; ferromagnetic aneurysm clips; cochlear implant; gastric reflux device; internal insulin pump; pacing leads; neurostimulation system) that cannot be cleared for scanning at 3T

- Foreign body (i.e., metallic splinter in the eye; bullet or grenade fragments)

- Braces or orthodontic appliances that cannot be removed prior to scanning and/or cannot be cleared for scanning at 3T

- Individuals who are unable to participate in the informed consent process or complete the study questionnaire will also be excluded from participation.
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