Metabolic Diet for Relapse Prevention in Anorexia Nervosa

This is an interventional study that will test the safety, tolerability, and efficacy of the Metabolic Diet, which was designed as a treatment for women with anorexia nervosa to remain weight-stable after they have been restored from low weight. Participants will be adult women with anorexia nervosa who have been recently restored to normal weight and adult women with no history of eating disorders. After enrollment, participants will start meeting weekly with a registered dietitian to implement the Metabolic Diet in their daily lives, and will receive medical monitoring for adherence, side effects, changes in metabolic or psychological parameters, and weight stability.

Inclusion Criteria:

- Female

- Age at least 18 and not over 40

- BMI at or above 18.5 kg/m2

- Speaks English

- Medically stable, as cleared by a licensed physician, with vital signs and initial blood draws

- History of DSM-5 diagnosis of Anorexia Nervosa (WR-AN only)

- Weight-restored from underweight BMI (under 18.5 kg/m2) within the past 6 months (WR-AN only)

Exclusion Criteria:

- Current/lifetime diagnosis of DSM-5 psychotic disorders, bipolar disorders

- Active DSM-5 substance use disorders

- On medications that could affect metabolism *Subjects are to be free of any medications that could affect metabolism, as discussed with study physician, for 2 weeks prior to primary study visit for glucose function testing.

- History of suicide attempt within previous 6 months or acute suicide risk

- Significant current medical illness or metabolic conditions, including diabetes mellitus and pregnancy

- Current/lifetime diagnosis of DSM-5 eating disorders (HC only)

- Active DSM-5 depressive disorders (HC only)

Conditions:
• Anorexia Nervosa
• Feeding and Eating Disorders