Improving Cognition Via Exercise in Schizophrenia
Age: 18 - 55 years
Healthy Subjects: No
Study Phase: N/A
Recruitment Status: Recruiting
Start Date: March 31, 2018
End Date: August 31, 2021
- A DSM-V diagnosis of schizophrenia, schizoaffective, or schizophreniform disorder.
- Age 18-55 years.
- Taking antipsychotic medication for at least 8 weeks and on current doses for 4 weeks, and/or injectable depot antipsychotics with no change in the last 3 months.
- Capacity to understand all the potential risks and benefits of the study.
- Medically cleared by a physician to take part in VO2max tests and aerobic exercise training or stretching-and-toning exercise training.
- A DSM-V diagnosis of alcohol/substance abuse (except nicotine) within the last month or a diagnosis of alcohol/substance dependence (except nicotine) within the last 6 months
- Initiation of anti-depressants, mood stabilizers, or other medications known to impact cognition in previous 4 weeks or any change in doses during this period.
- History of seizures/head trauma with loss of consciousness (>10 minutes) resulting in cognitive sequelae.
- Significant clinical abnormalities in physical examination, lab assessments, or ECG.
- Neurological/medical conditions that could interfere with study participation (e.g., unstable cardiac disease, stuttering).
- Body Mass Index (BMI) ≥ 40.
- Untreated hyper- or hypothyroidism.
- Being pregnant or nursing.
- Serious homicidal/suicidal risk (past 6 months).
- "Moderate" or more severe conceptual disorganization (PANSS≥4).
- Poor English reading ability (WTAR<7).
- Participation in a study with cognitive assessment in the past 3 months.
- Serious homicidal risk (past 6 months)