FAST (Focused Abbreviated Screening Technique)-MRI Study

ID#: NCT04539717

Age: 18 years - 66+

Gender: All

Healthy Subjects: No

Recruitment Status: Enrolling by invitation

Start Date: August 17, 2020

End Date: December 01, 2025

Summary: The purpose of this study is to compare the diagnostic value of a reconstructed abbreviated Magnetic Resonance Imaging (MRI) from a full clinical exam, compared to ultrasound (US) for screening of liver cancer. Blood markers will be evaluated to determine their correlation to imaging. This study will help to determine whether abbreviated MRI is superior to ultrasound for diagnosis of liver cancer.
Eligibility: Inclusion Criteria

- Liver cirrhosis of any etiology.

- 18 years of age and older.

- Enrolled in screening/surveillance program for HCC.

- Clinically indicated imaging-based screening for HCC.

- Willing and able to complete all study procedures within specified time windows.

- Patient is able to give informed consent for this study. Exclusion Criteria

- Contra-indications to MRI.

- Age less than 18 years.

- Patients with chronic renal failure or inability to tolerate contrast.

- Inability to undergo MRI due to lack of insurance coverage.

- Prior negative screening exam less than 5 months prior to enrollment.

- Prior hepatic resection.

- Post liver transplantation.

- Previously treated HCC or other liver neoplasm.

- Any other condition or factor that in judgment of study investigator may interfere with study completion.