OCEAN(a)-PreEvent - Olpasiran Trials of Cardiovascular Events And LipoproteiN(a) Reduction to Prevent First Major Cardiovascular Events
The primary objective is to evaluate the effect of olpasiran, compared to placebo, on the
risk for coronary heart disease death (CHD death), myocardial infarction, or urgent
coronary revascularization in participants at risk for a first major cardiovascular event
wit...
Age: 50 - 105 years
Gender: All
Exercise Activity Intervention With Sensor-Based Engagement in Patients With Atrial Fibrillation
Atrial fibrillation (AF) affects 1 in 4 individuals during their lifetime and continues
to increase in frequency and impact. Exercise intervention has established benefits to
improve AF symptoms and burden in clinical studies. However, lack of access to exercise
prog...
Age: 18 years - 66+
Gender: All
Inclisiran Versus Placebo for the Prevention of Major Adverse Cardiovascular and Limb Events in Patients Undergoing Percutaneous Coronary Intervention or Peripheral Endovascular Intervention
V-INTERVENTION will evaluate the effectiveness of inclisiran in preventing major
cardiovascular and limb events in patients receiving percutaneous coronary or peripheral
arterial revascularization. Inclisiran is a subcutaneous, twice-yearly injection that is
FDA-appr...
Age: 18 years - 66+
Gender: All
Safety and Performance Assessment of the Sphere-9™ Catheter and Affera™ Ablation System for the Treatment of Ventricular Tachycardia (Sphere-9 VT EFS)
Sphere-9 VT EFS is a prospective, multi-center, non-randomized, unblinded feasibility
study. Adult subjects with recurrent, sustained, scar-related monomorphic ventricular
tachycardia will be enrolled and treated with the Sphere-9 Catheter and Affera Ablation
System.
Age: 18 - 85 years
Gender: All
The Effect of Retatrutide Once Weekly on Cardiovascular Outcomes and Kidney Outcomes in Adults Living With Obesity (TRIUMPH-Outcomes)
The main purpose of this study is to determine if retatrutide can significantly lower the incidence of serious heart-related complications or prevent the worsening of kidney function. The trial will enroll adults with body mass index 27 kg/m^2 or higher and Atherosclero...
Age: 45 years - 66+
Gender: All
Investigation of the BrioVAD System for the Treatment of Left Ventricular Heart Failure
The goal of this study is to evaluate the safety and efficacy of the BrioVAD System by
demonstrating non-inferiority to the HeartMate 3 Left Ventricular Assist System when used
for the treatment of advanced, refractory, left ventricular heart failure.
Age: 18 - 100 years
Gender: All
MagicTouch™Sirolimus-Coated Balloon for Treatment of Coronary Artery Lesions in Small Vessels
This is a multicenter, randomized, single-blind pivotal study to evaluate the safety and
efficacy of the MagicTouchTM Drug coated balloon in treatment of small vessels in
patients with coronary artery disease. The objective is to establish the safety and
efficacy of ...
Age: 18 - 80 years
Gender: All
PROACTIVE-HF-2 Trial Heart Failure NYHA Class II and III
This is a prospective, multi-center, open label, randomized control clinical trial
evaluating the safety and efficacy of the Cordella™ Pulmonary Artery Sensor System in
NYHA Class II-III Heart Failure Patients (PROACTIVE-HF-2 Trial).
The study contains of 5 arms:
...
Age: 18 years - 66+
Gender: All