Sarah Millar, PhD Email Sarah Millar
- DIRECTOR, BLACK FAMILY STEM CELL INSTITUTE
- PROFESSOR | Cell, Developmental & Regenerative Biology
- PROFESSOR | Dermatology
- PROFESSOR | Oncological Sciences
Cancer, Cellular Differentiation, Chromatin, Dermatology, Developmental Biology, Differentiation, Epigenetics, Gene Expressions, Gene Regulation, Gene editing, Genetics, Genomics, Knockout Mice, Morphogenesis, Organogenesis, Receptors, Regeneration, Skin Cancer, Stem Cells, Transcription Factors, Transcriptional Activation and Repression, Transgenic Mice
Multi-Disciplinary Training Area
Development, Regeneration, and Stem Cells [DRS]
BA, Cambridge University
PhD, Imperial College, London University
Vice-President of the Society for Investigative Dermatology
Society for Investigative Dermatology
William Montagna Lectureship Award
Society for Investigative Dermatology
FOCUS Award for the Advancement of Women in Medicine
University of Pennsylvania
Executive Leadership in Academic Medicine (ELAM) fellow
Drexel University College of Medicine
Understanding the molecular and cellular mechanisms regulating the development, patterning and postnatal renewal of the skin and ectodermal appendage organs such as hair follicles, teeth, and taste papillae, and identifying stem and progenitor cell populations in these organs, is critical for developing new therapies to accelerate wound healing, treat hair loss diseases, repair or replace diseased teeth, and ameliorate taste dysfunction. Research in the Millar lab focuses on cell-cell signaling and epigenetic mechanisms that underlie these processes. In published research, we identified Wnt/beta-catenin signaling as a key pathway required for initiating the formation of ectodermal appendages from multipotent cells in mammalian embryos, and in controlling development and patterning of haired versus hairy skin. By analyzing genetic mouse models and tissues from human patients carrying mutations in the WNT10A gene, we showed that Wnt signaling plays key roles in regulating the functions of a wide variety of adult epithelial stem cells, as well as controlling specialized differentiation programs in palmoplantar skin. We have also identified critical functions for epigenetic regulators including micro-RNAs and chromatin modifiers in skin development and regeneration. Ongoing research interests include: - Investigating mechanisms that cause ectodermal dysplasia in patients with mutations in the WNT10A gene and testing potential therapeutic strategies - Determining the mechanisms that underlie the formation and maintenance of hairy versus hairless skin and regulate hair patterning - Delineating the functions of histone deacetylase chromatin modifiers in skin development, stem cells and cancer - Identifying pioneer transcription factors that control development and stem cell activity in skin and oral epithelia For more detailed information please visit the Millar lab website: labs.icahn.mssm.edu/millarlab/
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Dr.Millar did not report having any of the following types of financial relationships with industry during 2020 and/or 2021: consulting, scientific advisory board, industry-sponsored lectures, service on Board of Directors, participation on industry-sponsored committees, equity ownership valued at greater than 5% of a publicly traded company or any value in a privately held company. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.
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