Sarah Millar, PhD Email Sarah Millar
- DIRECTOR, BLACK FAMILY STEM CELL INSTITUTE
- SENIOR ASSOCIATE DEAN FOR BASIC RESEARCH
- PROFESSOR | Cell, Developmental & Regenerative Biology
- PROFESSOR | Oncological Sciences
- PROFESSOR | Dermatology
Cancer, Cellular Differentiation, Chromatin, Dermatology, Developmental Biology, Differentiation, Epigenetics, Gene Expressions, Gene Regulation, Gene editing, Genetics, Genomics, Knockout Mice, Morphogenesis, Organogenesis, Receptors, Regeneration, Skin Cancer, Stem Cells, Transcription Factors, Transcriptional Activation and Repression, Transgenic Mice
Multi-Disciplinary Training Area
Development, Regeneration, and Stem Cells [DRS]
BA, Cambridge University
PhD, Imperial College, London University
Vice-President of the Society for Investigative Dermatology
Society for Investigative Dermatology
William Montagna Lectureship Award
Society for Investigative Dermatology
FOCUS Award for the Advancement of Women in Medicine
University of Pennsylvania
Executive Leadership in Academic Medicine (ELAM) fellow
Drexel University College of Medicine
Understanding the molecular and cellular mechanisms regulating the development, patterning and postnatal renewal of the skin and ectodermal appendage organs such as hair follicles, teeth, and taste papillae, and identifying stem and progenitor cell populations in these organs, is critical for developing new therapies to accelerate wound healing, treat hair loss diseases, repair or replace diseased teeth, and ameliorate taste dysfunction. Research in the Millar lab focuses on cell-cell signaling and epigenetic mechanisms that underlie these processes. In published research, we identified Wnt/beta-catenin signaling as a key pathway required for initiating the formation of ectodermal appendages from multipotent cells in mammalian embryos, and in controlling development and patterning of haired versus hairy skin. By analyzing genetic mouse models and tissues from human patients carrying mutations in the WNT10A gene, we showed that Wnt signaling plays key roles in regulating the functions of a wide variety of adult epithelial stem cells, as well as controlling specialized differentiation programs in palmoplantar skin. We have also identified critical functions for epigenetic regulators including micro-RNAs and chromatin modifiers in skin development and regeneration. Ongoing research interests include: - Investigating mechanisms that cause ectodermal dysplasia in patients with mutations in the WNT10A gene and testing potential therapeutic strategies - Determining the mechanisms that underlie the formation and maintenance of hairy versus hairless skin and regulate hair patterning - Delineating the functions of histone deacetylase chromatin modifiers in skin development, stem cells and cancer - Identifying pioneer transcription factors that control development and stem cell activity in skin and oral epithelia For more detailed information please visit the Millar lab website: labs.icahn.mssm.edu/millarlab/
Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.
Below are financial relationships with industry reported by Dr. Millar during 2021 and/or 2022. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.
Industry-Sponsored Lectures: MSSM faculty occasionally give lectures at events sponsored by industry, but only if the events are free of any marketing purpose
- Albert Einstein
Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.
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