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Isabelle M Germano, MD, MBA

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Mount Sinai Doctors ?
    • Positions
    • PROFESSOR | Neurosurgery
    • PROFESSOR | Neurology
    • PROFESSOR | Oncological Sciences
    • Specialties
    • Neurosurgery
    • Cancer (Oncology)
    • Languages
    • English
    • Italian
    • French
    • Spanish
    • German
    • Hospital Affiliations
    • Mount Sinai Beth Israel
    • The Mount Sinai Hospital
    • Mount Sinai Morningside and Mount Sinai West
    • Phone
    • Mount Sinai Doctors Faculty Practice 212-241-9638
    • Ruttenberg Treatment Center 212-241-6756
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Dr. Germano joined the faculty at Mount Sinai in 1993. She is Director of The Mount Sinai Comprehensive Brain Tumor Program, an advanced multidisciplinary program based on computer-assisted image-guided neurosurgery and brain mapping to accomplish minimally invasive procedures and treatment of brain tumors. She is also Vice Chair for Diversity and Inclusion and Co-Director of the Radiosurgery Program.

Watch a video about Dr. Germano or learn more about her by visiting the Neurosurgery Tumors website.

Dr. Germano's specialty interests include brain tumors, computer-assisted image-guided neurosurgery, epilepsy surgery, neuro-oncology, and radiosurgery. She is one of the pioneers of computer-assisted image-guided neurosurgery. This sophisticated technology, including the Novalis Shaped Beam Surgery, is used to perform minimally invasive surgery for patients with brain tumors, epilepsy, Parkinson's disease and movement disorders. Active in national neurosurgery organizations, Dr. Germano has served as an executive committee member for the Congress of Neurosurgery (CNS), as a member of the Board of Directors for the American Association of Neurological Surgeons (AANS), as an executive committee member of the AANS/CNS Joint Section on Tumors, and as a scientific program member for the AANS, CNS, and the American Epilepsy Society. For the past five years she has directed a course, "Advanced Techniques in Image-Guided Brain and Spine Surgery," for neurosurgeons from around the country.

In the News

Dr. Germano and her work diagnosing and treating brain tumors were profiled in The Daily News feature The Daily Check Up. View the PDF.

Dr. Germano was chosen to give the Charles A. Elsberg Lecture, the first woman to receive this honor since the lecture’s establishment 67 years ago. Read about her honor.


Neurological Surgery

Clinical Focus

  • Acoustic Neuroma
  • Astrocytoma
  • Biopsy
  • Brain Metastasis
  • Brain Tumor And Brain Cancer
  • Brain, Spine Tumors
  • Craniotomy
  • Epilepsy
  • Glioblastoma Multiforme
  • Meningioma
  • Neuro-Oncology
  • Pituitary Adenoma
  • Stereotactic Radiosurgery

Research Topic

Anti-Tumor Therapy, Apoptosis/Cell Death, Autophagy, Brain, Cancer, Cellular Differentiation, Gene Expressions, Gene Therapy, Metastasis, Migration, Molecular Biology, Neuroscience, Seizure, Stem Cells, Translation, Tumor Suppressor Genes, Tumorigenesis

Multi-Disciplinary Training Area

Development, Regeneration, and Stem Cells [DRS]


MD, University of Turin Medical School

Residency, Surgery
Univ. of California, San Francisco

Residency, Neurosurgery
Univ. of California, San Francisco

Residency, Neurosurgery
Albert Einstein College of Medicine

Fellowship, Neurosurgery
University of Zurich

Fellowship, Neurosurgery
Montreal Neurological Institute


English, Italian, French, Spanish, German