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Hanna Y Irie, MD, PhD

Cancer (Oncology)
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Mount Sinai Doctors ?
    • Positions
    • ASSOCIATE PROFESSOR | Medicine, Hematology and Medical Oncology
    • ASSOCIATE PROFESSOR | Oncological Sciences
    • Specialties
    • Cancer (Oncology)
    • Hematology-Oncology
    • Language
    • English
    • Hospital Affiliation
    • The Mount Sinai Hospital
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I am a medical oncologist specializing in the care of patients with breast cancer. As a physician-scientist, I also lead a research laboratory that is focused on developing targeted therapies tailored for specific breast cancer subtypes and for individual patients. I have a particular interest in better understanding triple negative breast cancers, with the goal of integrating genetic analysis to the development of improved treatments for our patients.

I am co-PI of the Breast Tumor Biospecimen Repository, which is a bank of patient breast tumors; analysis of these tumors will provide insights into the genetic changes that determine sensitivity to specific targeted therapies for breast cancer. I am also co-PI of a study investigating the use of patient-derived xenograft models as a model for chemotherapy treatment sensitivity for patients with triple negative breast cancers; if successful, these models may be used in the future to help us better tailor treatments for individual patients. My research laboratory has identified several new candidate therapeutic targets for Her2+ and triple negative breast cancers resistant to current treatments, and we are working to translate our findings to clinical studies and trials.

I am a member of the American Society of Clinical Oncology and the American Association for Cancer Research.





Medical Oncology

Clinical Focus

Research Topics

Anti-Tumor Therapy, Cancer, Cell Biology, Cell Transformation, Growth Factors and Receptors, Protein Kinases


MD,PHD, Harvard Medical School

BA, Harvard University

Clinical Fellow, Dana-Farber Cancer Institute

Instructor, Dana-Farber Cancer Institute/Harvard Medical School

Intern/Resident, Massachusetts General Hospital

MD, Harvard Medical School

PhD, Harvard Medical School

Research Fellow, Harvard Medical School

Residency, Internal Medicine
Massachusetts General Hospital

Fellowship, Hematology-Oncology
Dana Farber Cancer Institute