Dushyant P Purohit, MD Email Dushyant Purohit
- ASSOCIATE PROFESSOR | Pathology
- ASSOCIATE PROFESSOR | Psychiatry
- Anatomic Pathology & Clinical Pathology
- Hospital Affiliations
- The Mount Sinai Hospital
- Mount Sinai Beth Israel
Dr. Dushyant Purohit is a clinical and academic neuropathologist working as attending neuropathologist and holding a position of Associate Professor of Pathology and Psychiatry at Icahn School of Medicine at Mount Sinai. His research work on dementia had spanned for almost 30 years at Mount Sinai while working on multiple NIH grant-funded programs where he contributed in neuropathological characterization, clinicopathological correlation and phenotypic research on Alzheimer’s disease, movement disorders, ALS-Parkinson-dementia complex of Guam, schizophrenia and brain aging. He also carries out clinical diagnostic work in neuropathology in the Department of Pathology at Mount Sinai. Dr. Purohit offers teaching in the department’s Neuropathology Fellowship program providing 2-year training to two Fellows and to pathology residents and medical students.
Research on dementia and other neurodegenerative disorders: Just when Alzheimer’s Disease Research Center started, Dr. Purohit had joined Dr. Daniel Perl in developing Neuropathology Core of the Mount Sinai ADRC as also in comprehensive neuropathology research support to studies on neurodegenerative disorders under NIH-grant funded research programs including studies on brain aging, ALS-PD complex of Guam, schizophrenia and neurobiological research under the Conte Center program at Mount Sinai. Several studies attributed to Dr. Purohit’s research work included correlation of lesion loads of amyloid plaques, neurofibrillary tangles and Lewy bodies with levels of cognitive impairment, correlation of the risk factors of Alzheimer’s disease, (diabetes, hypertension, vascular injury, depression), studies on movement disorders, and brain changes in schizophrenia, ALS-PDC of Guam, traumatic brain injury and age-related cognitive loss in India. Dr. Purohit has also been providing data and consultation to NACC (National Alzheimer Center Consortium) and had participated in the CERAD group (1990). He participated in study sections for NIH grants.
Brain Banking: Dr. Purohit’s work in neuropathology research led him to engage in brain banking. In Mount Sinai/VA Neurodegenerative Disorders Brain Bank where over 2000 brain specimens have been banked as snapped frozen and formalin fixed specimens, and samples for molecular studies. This activity has recently morphed into a NIH NeuroBioBank center (2013- current), one of the six Brain Banking sites of the NIH directed and managed consortium that aims to make available to neuroscience researchers an unprecedented volume and varieties of brain tissue and other material in Sinai and in centers across the US and internationally. Recently a Mount Sinai for Neurodegenerative Disorders Brain Bank (NDBB) and Research Neuropathology Core established jointly in the Department of Pathology and the Friedman Brain Institute. Dr. Purohit participates as Co-Director for this newly established brain Bank. This endeavor has an additional focus on advancing neuroscience and clinical research by adopting the newer research and archival methods using digital pathology and machine learning.
Research development in the Low and Middle Income Countries: Dr. Purohit’s interest in dementia in developing countries led to his work as Principal Investigator for NIH-grant funded studies on cognitive loss in Indian population (years 2004-2012). This interest stems from his observation that in India, a typical LMIC, where apart from a few illustrious centers, dementia research has been very sparse. His attempt to set up research on dementia in India materialized when he was awarded R21 grant in 2004, and later a follow up R01, by NIH/Fogarty international Center. He is hoping to assist in similar future research programs. He has participated in WHO/WFN/IBRO cosponsored research symposia on dementia in developing countries held in Nairobi that are organized by Institute of Aging of Newcastle University in the UK
MD, B. J. Medical College
Newcastle General Hospital
Northern General Hospital
The Royal College of Pathologists
Newcastle General Hospital
Neurobiology of Neurodegenerative Diseases
The Neuropathology Laboratory and Brain Bank for Neurodegenerative Disorders provide neuropathology support to several federally funded grants for research projects on Alzheimer's disease, Parkinson disease and allied neurodegenerative diseases, and schizophrenia. The laboratory also offers specialized diagnostic reference facility for neurodegenerative disorders. The fully equipped laboratory conducts detailed descriptive studies to document the extent and distribution of various neuropathologic lesions in human brains obtained at autopsy from patients affected by a wide range of neurodegenerative diseases. The resulting characterization of morphologic lesions, diagnosis and clinicopathological correlation of the longitudinally studied cases become an integral part of several grant funded research studies. Our laboratory also has an extensive repository of study material of parkinsonism dementia complex (PDC) of Guam and the recently observed overlap of Alzheimer's disease in the Chamorro, the native inhabitants of Guam and other Marianas islands. Our study also involves the extent of overlap between morphologic changes encountered in other more common neurodegenerative disorders, including Alzheimer's disease, Parkinson's disease and allied movement disorders, Lewy body dementia, vascular dementia and variants of frontal lobe degeneration. Recently, we have focused our research activity on age-related cognitive disorders in the population of developing countries (or low and middle-income countries, as defined by the World Bank Survey of world economies) under a federally funded clinical and pathologic study on dementia and ageing in India and carry out necessary research capacity building there.
Purohit DP, Dick DJ, Perry RH, Lyons PR, Schofield IS, Foster JB. Solitary extranodal lymphoma of sciatic nerve.. J Neurol Sci. 1986; 74: 23-34.
Perry EK, Perry RH, Smith CJ, Purohit D, Bonham J, Dick DJ, Candy JM, Edwardson JA, Fairbairn A. Cholinergic receptors in cognitive disorders.. Can J Neurol Sci. 1986; 13 (supplement): 521-527.
Purohit DP, Perl DP. Proposal to revise the morphologic criteria for the diagnosis of Alzheimer's disease.. Neurobiol Aging 1997; 18: S81-S94.
Purohit DP, Perl DP, Haroutunian V, Powchik P, Davidson M, Losonczy M, Davis KL. Alzheimer's disease and related neurodegenerative diseases in elderly schizophrenic patients: a post-mortem neuropathologic study of 100 cases.. Arch Gen Psychiatry 1998;: 205-211.
Haroutunian V, Perl DP, Purohit DP, Marin D, Khan K, Lantz M, Davis KL, Mohs RC. Regional distribution of senile plaques in non-demented elderly and subjects with very mild Alzheimer's disease.. Arch Neurol. 1998; 55: 1185-1191.
Davis KL, Mohs RC, Marin DB, Purohit DP, Perl DP, Lantz M, Austin G, Haroutunian V. Cholinergic markers are not decreased in early Alzheimer's disease. . JAMA 1999; 281: 1401-1406.
Yahr MD, Orosz D, Purohit DP. Co-occurrence of essential tremor and Parkinsos disease: Clinical study of a large kindred with autopsy findings. Parkinsonism and Related Disorders 2003; 9: 225-231.
Perl DP, Hof PR, Purohit DP, Loerzel AJ, Kakulas BA. Hippocampal and entorhinal cortex neurofibrillary tangle formation in Guamanian Chamorros free of overt neurologic dysfunction. . J Neuropathol Exp Neurol. 2003; 62: 381-388.
Benveniste RJ, Purohit DP, Byun H. Pituicytoma presenting with spontaneous hemorrhage: Case report.. Pituitary 2006; 9: 53-58.
Rapp MA, Schnaider-Beeri M, Purohit DP, Perl DP, Haroutunian V, Sano M. Increased neurofibrillary tangles in patients with Alzheimer disease with comorbid depression.. Am J Geriatr Psychiatry. 2008 Feb; 16(2): 168-174.
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Dr.Purohit did not report having any of the following types of financial relationships with industry during 2018 and/or 2019: consulting, scientific advisory board, industry-sponsored lectures, service on Board of Directors, participation on industry-sponsored committees, equity ownership valued at greater than 5% of a publicly traded company or any value in a privately held company. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.
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