Arvin Dar, PhD Email Arvin Dar
- ASSOCIATE PROFESSOR | Oncological Sciences
- ASSOCIATE PROFESSOR | Pharmacological Sciences
Arvin Dar is Associate Professor, Oncological Sciences and Pharmacological Sciences, and Associate Director of the Mount Sinai Center for Therapeutic Discovery. With a training focus on structural biology and small molecule design and synthesis, Dr. Dar conducts research on developing new therapeutic approaches for disease, particularly small molecule modulators for targeting RAS-driven cancers. His work provides insights into the regulation of oncogenic RAS and offers a foundation for the development of targeted compounds that alter oncogenic signaling complexes. Dr. Dar’s laboratory also investigates target discovery for other disease areas, including hepatocellular carcinoma and rare genetic disorders such as RASopathies and tauopathies. Dr. Dar has received the NIH Director’s New Innovator Award, Damon-Runyon Rachleff Innovation Award, Pew-Stewart Scholarship for Cancer Research, and grant support from the Pershing Square Sohn Cancer Research Alliance, as well as other extramural funding.
Cancer, Drug Design and Discovery, Enzymology, Genetics, Protein Complexes, Structural Biology
Multi-Disciplinary Training Areas
Cancer Biology [CAB], Immunology [IMM], Pharmacology and Therapeutics Discovery [PTD]
BSc, University of Western Ontario
PhD, University of Toronto
Postdoctoral Training, University of California, San Francisco
Damon Runyon-Rachleff Innovation Award
Damon Runyon Cancer Research Foundation
Pew-Stewart Scholar for Cancer Research
The Pew and Alexander and Margaret Stewart Charitable Trusts
NIH Director’s New Innovator Award
National Institute of Health
Dean's Postdoctoral Prize
Tisch Cancer Institute Developmental Fund Award
BCRP Multidisciplinary Postdoctoral Award
US Department of Defense
Canadian Graduate Scholarship
Canadian Institutes for Health Research
Pershing Square Sohn Prize for Young Investigators (PSSCRA)
Through the development and understanding of small molecules, our lab explores links between the regulation of drug targets and the system level properties of biological networks within cells and animals. Our goals are to create new tools to modulate and explore biomolecular function, with a long-term objective of developing innovative medicines for disease. Our work is highly interdisciplinary, employing methods from synthetic organic chemistry, X-ray crystallography, mass spectrometry, informatics, biochemistry and model organism genetics.
In one research area we are investigating one of the most frequently activated pathways in cancer biology: the Ras-Mitogen Activated Protein Kinase (MAPK) pathway. Oncogenic forms of Ras occur in over 20% of all cancers. These mutants have stifled direct pharmacological approaches and inhibitors for the direct effectors of Ras have shown limited or no efficacy in patients. We are exploring new targets or strategies to modulate the Ras pathway through the development of chemical tools. In particular, we are using target-based and systems pharmacology approaches to generate new classes of small molecule modulators for the Ras pathway.
Postdoctoral Fellows: Alex Scopton, Zaigham Khan, Jayasudhan Yerabolu
Current Students: Jia (Annie) Yu, Ryan Smith, Alexander Real, Arthur Chow
Research Assistant: Lisa Silber
Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.
Below are financial relationships with industry reported by Dr. Dar during 2019 and/or 2020. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.
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