Andrew Stewart, MD Email Andrew Stewart
- DIRECTOR, DIABETES OBESITY AND METABOLISM INSTITUTE
- PROFESSOR | Medicine, Endocrinology, Diabetes and Bone Disease
Dr. Andrew Stewart’s research focuseson understanding and developing novel means for inducing the replication and regeneration of insulin-producing pancreatic beta cells. As Chief of the Division of Endocrinology and Metabolism at the University of Pittsburgh School of Medicine, Dr. Stewart and his research team were the first to demonstrate that adult human beta cells could be induced to replicate at substantial rates. Three long-time colleagues from that group are joining him: Donald K. Scott, PhD; Adolfo García-Ocaña, PhD; and Rupangi Chhaya Vasavada, PhD, as Professors in the Division of Endocrinology, Diabetes and Bone Disease, and as members of the Institute. Dr. Stewart, who has also been named Professor of Medicine (Endocrinology, Diabetes & Bone Diseases) will oversee the continued expansion of the Institute through the recruitment of additional researchers.
Dr. Stewart has devoted more than 30 years to patient care and scientific research, and received numerous honors, including the prestigious Aurbach award of The Endocrine Society, and also served as Program Chair for the American Diabetes Association Annual Scientific Sessions in 2010 and 2012. He has published more than 230 clinical and scientific papers in journals including the Proceedings of the National Academy of Sciences, The New England Journal of Medicine, and Science. He received his bachelor's degree from Trinity College in Hartford, Connecticut, and his MD from Columbia University, College of Physicians and Surgeons, in New York. He served as a fellow in Endocrinology and Metabolism and faculty member at Yale University School of Medicine in Connecticut, and later as Chief of the Division of Endocrinology at the University of Pittsburgh. Dr. Stewart currently has strong funding support from the National Institutes of Health, the Juvenile Diabetes Research Foundation, and other agencies.
Read about Dr. Stewart's research on the Inside Mount Sinai blog.
Autoimmunity, Cell Biology, Cell Cycle, Cell Division, Cellular Differentiation, DNA Replication, Diabetes, Gene Discovery, Gene Expressions, Gene Therapy, Genomics, Growth Factors and Receptors, Hormones, Immunosuppression, Insulin, Knockout Mice, Obesity, Oncogenes, Phosphorylation, Protein Kinases, Proteomics, Receptors, Transgenic Mice, Transplantation, Tumor Suppressor Genes
Multi-Disciplinary Training Areas
Development, Regeneration, and Stem Cells [DRS], Genetics and Data Science [GDS], Pharmacology and Therapeutics Discovery [PTD]
MD, Columbia University, College of Physicians and Surgeons
Dr. Andrew Stewart is the Scientific Director of the Diabetes, Obesity and Metabolism Institute (DOMI). He an authority on human insulin-producing pancreatic beta cell replication and regeneration for people with diabetes. His research focuses on understanding and developing novel therapies for inducing human beta cell regeneration, from gene therapy to small molecule drug discovery. His group was the first to demonstrate that growth factors could drive beta cell replication in vivo in mammals, and also improve glucose control in living animals. His group was also the first to carefully define cell cycle control in the rodent and human beta cell. They were also the first to report that small molecule drugs that inhibit the enzyme DYRK1A are able to induce human beta cells to replicate, and to reverse diabetes in vivo in mice transplanted with human beta cells. He is actively involved in developing next-generation DYRK1A inhibitors for human diabetes, and understanding why human beta cells are so refractory to replication. His work has been continually supported by the NIH/NIDDK and the JDRF.
Please visit the Stewart Laboratory.
Kulkarni RN, Mizrachi EB, Ocana AG, Stewart AF. Human β-cell proliferation and intracellular signaling: driving in the dark without a road map. Diabetes 2012 Sep; 61(9).
Metukuri MR, Zhang P, Basantani MK, Chin C, Stamateris RE, Alonso LC, Takane KK, Gramignoli R, Strom SC, O'Doherty RM, Stewart AF, Vasavada RC, Garcia-Ocaña A, Scott DK. ChREBP mediates glucose-stimulated pancreatic β-cell proliferation. Diabetes 2012 Aug; 61(8).
Takane KK, Kleinberger JW, Salim FG, Fiaschi-Taesch NM, Stewart AF. Regulated and reversible induction of adult human β-cell replication. Diabetes 2012 Feb; 61(2).
Walpita D, Hasaka T, Spoonamore J, Vetere A, Takane KK, Fomina-Yadlin D, Fiaschi-Taesch N, Shamji A, Clemons PA, Stewart AF, Schreiber SL, Wagner BK. A human islet cell culture system for high-throughput screening. Journal of biomolecular screening 2012 Apr; 17(4).
Rieck S, Zhang J, Li Z, Liu C, Naji A, Takane KK, Fiaschi-Taesch NM, Stewart AF, Kushner JA, Kaestner KH. Overexpression of hepatocyte nuclear factor-4α initiates cell cycle entry, but is not sufficient to promote β-cell expansion in human islets. Molecular endocrinology (Baltimore, Md.) 2012 Sep; 26(9).
Fiaschi-Taesch NM, Kleinberger JW, Salim F, Troxell R, Wills R, Tanwir M, Casinelli G, Cox AE, Takane KK, Srinivas H, Scott DK, Stewart AF. Cytoplasmic-Nuclear Trafficking of G1/S Cell Cycle Molecules and Adult Human Beta Cell Replication: A Revised Model of Human Beta Cell G1/S Control. Diabetes 2013 Mar;.
Fiaschi-Taesch NM, Kleinberger JW, Salim F, Troxell R, Wills R, Tanwir M, Casinelli G, Cox AE, Takane KK, Scott DK, Stewart AF. A Human Pancreatic Beta Cell G1/S Molecule Cell Cycle Atlas. Diabetes 2013 Mar;.
Carneiro RM, Prebehalla L, Tedesco MB, Sereika SM, Gundberg CM, Stewart AF, Horwitz MJ. Evaluation of markers of bone turnover during lactation in African-Americans: a comparison with Caucasian lactation. The Journal of clinical endocrinology and metabolism 2013 Feb; 98(2).
Vigersky RA, Fish L, Hogan P, Stewart A, Kutler S, Ladenson PW, McDermott M, Hupart KH. The clinical endocrinology workforce: current status and future projections of supply and demand. The Journal of clinical endocrinology and metabolism 2014 Sep; 99(9).
Bernal-Mizrachi E, Kulkarni RN, Scott DK, Mauvais-Jarvis F, Stewart AF, Garcia-Ocaña A. Human β-cell proliferation and intracellular signaling part 2: still driving in the dark without a road map. Diabetes 2014 Mar; 63(3).
Bender A, Stewart AF. Good news for the ageing beta cell. Diabetologia 2014 Feb; 57(2).
Stewart AF. Betatrophin versus bitter-trophin and the elephant in the room: time for a new normal in β-cell regeneration research. Diabetes 2014 Apr; 63(4).
García-Ocaña A, Stewart AF. RAS”ling beta cells to proliferate for diabetes: why do we need MEN? . The Journal of clinical investigation 2014 Sep; 124(9).
Kulkarni RN, Stewart AF. Summary of the Keystone islet workshop (April 2014): the increasing demand for human islet availability in diabetes research. Diabetes 2014 Dec; 63(12).
Wang P, Alvarez-Perez JC, Felsenfeld DP, Liu H, Sivendran S, Bender A, Kumar A, Sanchez R, Scott DK, Garcia-Ocaña A, Stewart AF. A high-throughput chemical screen reveals that harmine-mediated inhibition of DYRK1A increases human pancreatic beta cell replication. Nature medicine 2015 Apr; 21(4).
Chen H, Kleinberger JW, Takane KK, Salim F, Fiaschi-Taesch N, Pappas K, Parsons R, Jiang J, Zhang Y, Liu H, Wang P, Bender AS, Frank SJ, Stewart AF. Augmented Stat5 Signaling Bypasses Multiple Impediments to Lactogen-Mediated Proliferation in Human β-Cells. Diabetes 2015 Nov; 64(11).
Wang P, Fiaschi-Taesch NM, Vasavada RC, Scott DK, García-Ocaña A, Stewart AF. Diabetes mellitus--advances and challenges in human β-cell proliferation. Nature reviews. Endocrinology 2015 Apr; 11(4).
Stewart AF, Hussain MA, García-Ocaña A, Vasavada RC, Bhushan A, Bernal-Mizrachi E, Kulkarni RN. Human β-cell proliferation and intracellular signaling: part 3. Diabetes 2015 Jun; 64(6).
Mozar A, Lin H, Williams K, Chin C, Li R, Kondegowda NG, Stewart AF, Garcia-Ocaña A, Vasavada RC. Parathyroid Hormone-Related Peptide (1-36) Enhances Beta Cell Regeneration and Increases Beta Cell Mass in a Mouse Model of Partial Pancreatectomy. PloS one 2016; 11(7).
Aamodt KI, Aramandla R, Brown JJ, Fiaschi-Taesch N, Wang P, Stewart AF, Brissova M, Powers AC. Development of a reliable automated screening system to identify small molecules and biologics that promote human β-cell regeneration. American journal of physiology. Endocrinology and metabolism 2016 11; 311(5).
Akerman I, Tu Z, Beucher A, Rolando DM, Sauty-Colace C, Benazra M, Nakic N, Yang J, Wang H, Pasquali L, Moran I, Garcia-Hurtado J, Castro N, Gonzalez-Franco R, Stewart AF, Bonner C, Piemonti L, Berney T, Groop L, Kerr-Conte J, Pattou F, Argmann C, Schadt E, Ravassard P, Ferrer J. Human Pancreatic β Cell lncRNAs Control Cell-Specific Regulatory Networks. Cell metabolism 2017 Feb; 25(2).
Sacaan AI, Thibault S, Hong M, Kondegowda NG, Nichols T, Li R, Rosselot C, Evering W, Fenutria R, Vitsky A, Brown T, Finkelstein M, Garcia-Ocaña A, Khan N, Stewart AF, Vasavada RC. CDK4/6 Inhibition on Glucose and Pancreatic Beta Cell Homeostasis in Young and Aged Rats. Molecular cancer research : MCR 2017 11; 15(11).
Wang H, Bender A, Wang P, Karakose E, Inabnet WB, Libutti SK, Arnold A, Lambertini L, Stang M, Chen H, Kasai Y, Mahajan M, Kinoshita Y, Fernandez-Ranvier G, Becker TC, Takane KK, Walker LA, Saul S, Chen R, Scott DK, Ferrer J, Antipin Y, Donovan M, Uzilov AV, Reva B, Schadt EE, Losic B, Argmann C, Stewart AF. Insights into beta cell regeneration for diabetes via integration of molecular landscapes in human insulinomas. Nature communications 2017 10; 8(1).
Puri S, Roy N, Russ HA, Leonhardt L, French EK, Roy R, Bengtsson H, Scott DK, Stewart AF, Hebrok M. Replication confers β cell immaturity. Nature communications 2018 02; 9(1).
Karakose E, Ackeifi C, Wang P, Stewart AF. Advances in drug discovery for human beta cell regeneration. Diabetologia 2018 May;.
Horwitz MJ, Augustine M, Khan L, Kahn L, Martin E, Oakley CC, Carneiro RM, Tedesco MB, Laslavic A, Sereika SM, Bisello A, Garcia-Ocaña A, Gundberg CM, Cauley JA, Stewart AF. A comparison of parathyroid hormone-related protein (1-36) and parathyroid hormone (1-34) on markers of bone turnover and bone density in postmenopausal women: the PrOP study. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2013 Nov; 28(11).
Kumar K, Man-Un Ung P, Wang P, Wang H, Li H, Andrews MK, Stewart AF, Schlessinger A, DeVita RJ. Novel selective thiadiazine DYRK1A inhibitor lead scaffold with human pancreatic β-cell proliferation activity. European journal of medicinal chemistry 2018 Sep; 157.
Kumar K, Wang P, Sanchez R, Swartz EA, Stewart AF, DeVita RJ. Development of Kinase-Selective, Harmine-Based DYRK1A Inhibitors that Induce Pancreatic Human β-Cell Proliferation. Journal of medicinal chemistry 2018 Sep; 61(17).
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Dr. Stewart has not yet completed reporting of Industry relationships.
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