Dr. Li and her work were recently profiled in The Daily News feature The Daily Check Up. View the PDF.
National Cert Commission of Acupunture & Oriental Medicine
Allergy, B Cells, Cellular Immunity, Cytokines, Immunological Tolerance, Immunology, Inflammation, Lymphocytes, Memory, T Cells, cAMP
Cancer Biology [CAB], Immunology [IMM]
MD, Henan Medical University
Principal investigator: Xiu-Min Li, M.D., associate professor of pediatric allergy/immunology, Mount Sinai School of Medicine, New York, New York.
Dr. Li and her colleagues are studying a three-herb Chinese formula called ASHMI as a therapy for asthma. ASHMI, which was developed at Mount Sinai, is based on a formula that Dr. Li was familiar with from her practice of medicine in China. Dr. Li notes that there is not yet any effective therapy for persistent, severe asthma, nor any way to prevent it. Also, while conventional therapies can be helpful for many asthma patients, she says, corticosteroids (the cornerstone of treatment) often cause serious side effects and, if the medication is stopped, worsen the disease.
This CERC's three studies are looking at the mechanism of action of ASHMI in an animal model, finding out more about its active components, and investigating it in phase I and phase II clinical trials. So far, the team has found that ASHMI has broad therapeutic actions on multiple asthma-related mechanisms in an animal model, and that the effects are long lasting. They have almost completed their phase I study and are moving toward a proposed phase II clinical trial. "The beauty of a CERC," says Dr. Li, "is that we have three independent but highly interactive projects and experts from many fields. Studying and developing a first-generation botanical drug is a very big project."
Song Y, Dunkin D, Dahan S, Iuga A, Ceballos C, Hoffstadter-Thal K, Yang N, Benkov K, Mayer L, Li XM. Anti-inflammatory effects of the Chinese herbal formula FAHF-2 in experimental and human IBD. Inflammatory bowel diseases 2014 Jan; 20(1).
Srivastava KD, Dunkin D, Liu C, Yang N, Miller RL, Sampson HA, Li XM. Effect of Antiasthma Simplified Herbal Medicine Intervention on neutrophil predominant airway inflammation in a ragweed sensitized murine asthma model. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 2014 Apr; 112(4).
Yang N, Chung D, Liu C, Liang B, Li XM. Weight loss herbal intervention therapy (W-LHIT) a non-appetite suppressing natural product controls weight and lowers cholesterol and glucose levels in a murine model. BMC complementary and alternative medicine 2014 Jul; 14.
Ceballos C, Bao R, Dunkin D, Song Y, Li XM, Benkov K. Complementary and alternative medicine use at a single pediatric inflammatory bowel disease center. Gastroenterology nursing : the official journal of the Society of Gastroenterology Nurses and Associates 2014 Jul-Aug; 37(4).
Birmingham JM, Gillespie VL, Srivastava K, Li XM, Busse PJ. Influenza A infection enhances antigen-induced airway inflammation and hyperresponsiveness in young but not aged mice. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2014 Sep; 44(9).
Zhou Z, Gong S, Li X, Yang Y, Guan R, Zhou S, Yao S, Xie Y, Ou Z, Zhao J, Liu Z. Expression of Helicobacter pylori urease B on the surface of Bacillus subtilis spores. Journal of medical microbiology 2014 Oct;.
Yang N, Wang J, Liu C, Song Y, Zhang S, Zi J, Zhan J, Masilamani M, Cox A, Nowak-Wegrzyn A, Sampson H, Li XM. Berberine and limonin suppress IgE production by human B cells and peripheral blood mononuclear cells from food-allergic patients. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 2014 Nov; 113(5).
Song Y, Liu C, Hui Y, Srivastava K, Zhou Z, Chen J, Miller RL, Finkelman FD, Li XM. Maternal allergy increases susceptibility to offspring allergy in association with TH2-biased epigenetic alterations in a mouse model of peanut allergy. The Journal of allergy and clinical immunology 2014 Dec; 134(6).
Lisann L, Song Y, Wang J, Ehrlich P, Maitland A, Li XM. Successful prevention of extremely frequent and severe food anaphylaxis in three children by combined traditional Chinese medicine therapy. Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology 2014 Dec; 10(1).
López-Expósito I, Srivastava KD, Birmingham N, Castillo A, Miller RL, Li XM. Maternal Antiasthma Simplified Herbal Medicine Intervention therapy prevents airway inflammation and modulates pulmonary innate immune responses in young offspring mice. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 2015 Jan; 114(1).
Liu C, Weir D, Busse P, Yang N, Zhou Z, Emala C, Li XM. The Flavonoid 7,4'-Dihydroxyflavone Inhibits MUC5AC Gene Expression, Production, and Secretion via Regulation of NF-κB, STAT6, and HDAC2. Phytotherapy research : PTR 2015 Mar;.
Song Y, Wang J, Leung N, Wang LX, Lisann L, Sicherer SH, Scurlock AM, Pesek R, Perry TT, Jones SM, Li XM. Correlations between basophil activation, allergen-specific IgE with outcome and severity of oral food challenges. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 2015 Apr; 114(4).
Liu C, Dunkin D, Lai J, Song Y, Ceballos C, Benkov K, Li XM. Anti-inflammatory Effects of Ganoderma lucidum Triterpenoid in Human Crohn's Disease Associated with Downregulation of NF-κB Signaling. Inflammatory bowel diseases 2015 May;.
Liu C, Yang N, Song Y, Wang L, Zi J, Zhang S, Dunkin D, Busse P, Weir D, Tversky J, Miller RL, Goldfarb J, Zhan J, Li XM. Ganoderic acid C1 isolated from the anti-asthma formula, ASHMI™ suppresses TNF-α production by mouse macrophages and peripheral blood mononuclear cells from asthma patients. International immunopharmacology 2015 May;.
Zhu LL, Yuan L, Wang H, Ye L, Yao GY, Liu C, Sun NN, Li XJ, Zhai SC, Niu LJ, Zhang JB, Ji HL, Li XM. A Meta-Analysis of Concurrent Chemoradiotherapy for Advanced Esophageal Cancer. PloS one 2015 Jun; 10(6).
Wang J, Jones SM, Pongracic JA, Song Y, Yang N, Sicherer SH, Makhija MM, Robison RG, Moshier E, Godbold J, Sampson HA, Li XM. Safety, clinical, and immunologic efficacy of a Chinese herbal medicine (Food Allergy Herbal Formula-2) for food allergy. The Journal of allergy and clinical immunology 2015 Jun;.
Chang LM, Song Y, Li XM, Sampson HA, Masilamani M. Dietary Elimination of Soybean Components Enhances Allergic Immune Response to Peanuts in BALB/c Mice. International archives of allergy and immunology 2015 Jun; 166(4).
Liu C, Yang N, Song Y, Wang L, Zi J, Zhang S, Dunkin D, Busse P, Weir D, Tversky J, Miller RL, Goldfarb J, Zhan J, Li XM. Ganoderic acid C1 isolated from the anti-asthma formula, ASHMI™ suppresses TNF-α production by mouse macrophages and peripheral blood mononuclear cells from asthma patients. International immunopharmacology 2015 Aug; 27(2).
Srivastava KD, Siefert A, Fahmy TM, Caplan MJ, Li XM, Sampson HA. Investigation of peanut oral immunotherapy with CpG/peanut nanoparticles in a murine model of peanut allergy. The Journal of allergy and clinical immunology 2016 Apr;.
Smith PK, Masilamani M, Li XM, Sampson HA. The false alarm hypothesis: Food allergy is associated with high dietary advanced glycation end-products and proglycating dietary sugars that mimic alarmins. The Journal of allergy and clinical immunology 2016 Jul;.
Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.
Below are financial relationships with industry reported by Dr. Li during 2016 and/or 2017. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.
Equity (Stock or stock options valued at greater than 5% ownership of a publicly traded company or equity of any value in a privately held company)
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