A 1979 graduate of the Icahn School of Medicine at Mount Sinai, he served as the President of Alpha Omega Alpha Honor Society, then was a Medical Resident at the Beth Israel Hospital, Harvard Medical School, Boston, followed by a Gastroenterology Fellowship at UCSF before assuming a faculty position there which he held for ten years. During a 1995-96 sabbatical from UCSF he was a Senior Fulbright Scholar and Visiting Professor at the Weizmann Institute of Science in Israel, in the laboratory of Professor Moshe Oren. Dr. Friedman has given invited honorary lectures throughout the world and has been a named lecturer or Visiting Professor at over 30 institutions worldwide. He is widely recognized as a dynamic, effective speaker, and is also a respected author, with over 300 peer-reviewed publications. Dr. Friedman was a recipient in 1993 of the Saul Horowitz, Jr. Outstanding Alumnus Award from Mount Sinai. In 2003, Dr. Friedman was honored with the International Hans Popper Award by the Falk Foundation in Freiburg, Germany, in recognition of his outstanding contributions to the understanding of liver disease and its treatment. He has mentored over 75 postdoctoral fellows and students, most of who remain in academic training programs or faculty. In 2012 he was awarded the European Association for the Study of Liver Diseases International Recognition Award in Barcelona, Spain, and in 2013 he was awarded the Shanghai Magnolia Gold Award by the Mayor of Shanghai and the China Friendship Award from the Premier of China in 2014 in recognition of his efforts to improve the health of the residents of Shanghai and China through his research achievements.
As Chief of the Division of Liver Diseases at Mount Sinai since 2001, Dr. Friedman has expanded the faculty from 5 to 25 individuals, increased NIH grant funding more than 5-fold, clinical trials income more than 10-fold, and overseen the creation of the largest liver fellowship in the United States. He has been a member of the American Society of Clinical Investigation since 1995, the Association of American Physicians since 2004, and was elected as a Fellow of the American Gastroenterological Association in 2008, the Am. College of Physicians in 2013, the American Assn. for the Study of Liver Diseases in 2014 and the American Association for the Advancement for Science in 2015. Dr. Friedman’s appointment in 2012 as Dean for Therapeutic Discovery at Mount Sinai recognizes his unique strengths in translating basic science into clinically meaningful advances, and his investigative work in liver disease has been instrumental in fueling the tremendous growth in emerging diagnostics and therapeutics for hepatic fibrosis.
As President of the American Assn. for the Study of Liver Diseases in 2009 (the sixth Mount Sinai faculty member to hold this position), Dr. Friedman oversaw several major new initiatives that accelerated its growth and brought the Association to new levels of income and international visibility.
Aerodigestive Tract, Anti-Tumor Therapy, Apoptosis/Cell Death, Autophagy, Biomedical Sciences, Cancer Genetics, Cell Biology, Cell Transformation, Developmental Biology, Drug Resistance, Endothelial Cells, Epithelial Cells, Extracellular Matrix, Fibrosis, Gene Regulation, Growth Factors and Receptors, Hepatitis C Virus, Integrins, Knockout Mice, Liver, Macrophage, Metastasis, Molecular Biology, Organogenesis, Oxidative Stress, Phosphorylation, Proteases, Receptors, Signal Transduction, Transcription Factors, Transcriptional Activation and Repression, Transgenic Mice, Tumor Suppressor Genes, Tumorigenesis, Vascular Development, Wound Healing
Biophysics and Systems Pharmacology [BSP], Cancer Biology [CAB], Genetics and Genomic Sciences [GGS]
BS, Rensselaer Polytechnic Institute
MD, Mount Sinai School of Medicine
none, Beth Israel Hospital, Harvard Medical School
none, University of California School of Medicine
EnglishDownload the CV
Am Assn for the Study of Liver Diseases Distinguished Achievement Award
Recognizes an outstanding body fo work contributing to the advancement of hepatology science
American Liver Foundation Distinguished Achievement Award
American Liver Foundation
Recognizes an outstanding body fo work contributing to the advancement of hepatology science
Burton Combes Memorial Lecture
UT Southwestern GI Division
Lecture honoring the memory of the former Chief of GI
Emmet B Keeffe Mentoring Award
Recognizes outstanding mentorship in the field of hepatology
Fellow, American Assn for the Advancement fo Science
Recognizes outstanding leadership in American science
Maud Menten Honorary Lecture
Lecture honoring the founding Chair of Pathology
Charles Lieber Memorial Lecture
American Gastroenterological Assn
Lecture honoring the contributions of Charles Lieber MD, to gastroenterology and hepatology
The Jacobi Medallion
The Icahn School of Medicine at Mount Sinai
The highest honor bestowed by the school for contributions to its mission
Rao Honorary Lecture
Feinberg School of Medicine, Northwestern U.
Salute to Excellence Award
American Liver Foundation, San Francisco Chapter
Recognizing outstanding contributions to liver research and clinical care
American Assn for the Study of Liver Diseases
Am Assn for the Study of Liver Diseases
China Friendship Award
Chinese Government, presented by the Premier of China
Recognizes outstanding contributions to advances benefiting the people of China
International Recognition Award
European Assn for the Study of LIver
Recognizes an international leader in the science of liver diseases
Shanghai Magnolia Gold Award
City of Shanghai
Recognizing outstanding contributions to the City of Shanghai
Master Educator Recognition
Mount Sinai Institute for Medical Education
University of Utah Dept of Medicine
Rafael Research Alumni Visiting Scientist
Rambam Hospital, Haifa, Israel
Sheila Sherlock Lecture
British Assn for Gastroenterology, Liverpool, UK
Sackler Distinguished Lectureship
Tel Aviv University, Israel
Fellow of the American Gastroenterological Assn
Ken & Louise Goldberg Visiting Professor
Brigham and Women's Hospital, Boston MA
Solomon Berson Dept of Medicine Housestaff Teaching Award
International Hans Popper Research Prize
Recognizes the most outstanidng liver scientist in the world under the age of 50 years old
International Hans Popper Award to Outstanding Researcher in Hepatology
Fulbright Senior Scholar Award
Arthur H. Aufses Sr., Prize in Surgery
Mount Sinai School of Medicine
Mechanisms of Hepatic Fibrosis and Cancer
Dr. Friedman is the Director of both the Division of Liver Diseaases and the Fibrosis Research Center, and is co-Director of the Tisch Cancer Institute Liver Cancer Program
Specific Clinical/Research Interest:
Bechmann LP, Vetter D, Ishida J, Hannivoort RA, Lang UE, Kocabayoglu P, Fiel MI, Muñoz U, Patman GL, Ge F, Yakar S, Li X, Agius L, Lee YM, Zhang W, Hui KY, Televantou D, Schwartz GJ, LeRoith D, Berk PD, Nagai R, Suzuki T, Reeves HL, Friedman SL. Post-transcriptional activation of PPAR alpha by KLF6 in hepatic steatosis. Journal of hepatology 2013 May; 58(5).
Hoshida Y, Villanueva A, Sangiovanni A, Sole M, Hur C, Andersson KL, Chung RT, Gould J, Kojima K, Gupta S, Taylor B, Crenshaw A, Gabriel S, Minguez B, Iavarone M, Friedman SL, Colombo M, Llovet JM, Golub TR. Prognostic gene expression signature for patients with hepatitis C-related early-stage cirrhosis. Gastroenterology 2013 May; 144(5).
Weiskirchen R, Weimer J, Meurer SK, Kron A, Seipel B, Vater I, Arnold N, Siebert R, Xu L, Friedman SL, Bergmann C. Genetic characteristics of the human hepatic stellate cell line LX-2. PloS one 2013; 8(10).
King LY, Canasto-Chibuque C, Johnson KB, Yip S, Chen X, Kojima K, Deshmukh M, Venkatesh A, Tan PS, Sun X, Villanueva A, Sangiovanni A, Nair V, Mahajan M, Kobayashi M, Kumada H, Iavarone M, Colombo M, Fiel MI, Friedman SL, Llovet JM, Chung RT, Hoshida Y. A genomic and clinical prognostic index for hepatitis C-related early-stage cirrhosis that predicts clinical deterioration. Gut 2014 Aug;.
Lee JM, Yang J, Newell P, Singh S, Parwani A, Friedman SL, Nejak-Bowen KN, Monga SP. β-Catenin signaling in hepatocellular cancer: Implications in inflammation, fibrosis, and proliferation. Cancer letters 2014 Feb; 343(1).
Kocabayoglu P, Lade A, Lee YA, Dragomir AC, Sun X, Fiel MI, Thung S, Aloman C, Soriano P, Hoshida Y, Friedman SL. β-PDGF receptor expressed by hepatic stellate cells regulates fibrosis in murine liver injury, but not carcinogenesis. Journal of hepatology 2015 Feb;.
Lu J, He L, Behrends C, Araki M, Araki K, Jun Wang Q, Catanzaro JM, Friedman SL, Zong WX, Fiel MI, Li M, Yue Z. NRBF2 regulates autophagy and prevents liver injury by modulating Atg14L-linked phosphatidylinositol-3 kinase III activity. Nature communications 2014; 5.
Son BK, Sawaki D, Tomida S, Fujita D, Aizawa K, Aoki H, Akishita M, Manabe I, Komuro I, Friedman SL, Nagai R, Suzuki T. Granulocyte macrophage colony-stimulating factor is required for aortic dissection/intramural haematoma. Nature communications 2015; 6.
Hasegawa D, Calvo V, Avivar-Valderas A, Lade A, Chou HI, Lee YA, Farias EF, Aguirre-Ghiso JA, Friedman SL. Epithelial Xbp1 Is Required for Cellular Proliferation and Differentiation during Mammary Gland Development. Molecular and cellular biology 2015 May; 35(9).
Zhang D, Goossens N, Guo J, Tsai M, Chou H, Altunkaynak C, Sangiovanni A, Ivarone M, Colombo M, Kobayashi M, Kumada H, Villanueva A, Llovet J, Hoshida Y, Friedman S. A hepatic stellate cell gene expression signature associated with outcomes in hepatitis C cirrhosis and hepatocellular carcinoma after curative resection. . Gut 2015;.
Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.
Below are financial relationships with industry reported by Dr. Friedman during 2016 and/or 2017. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.
Equity (Stock or stock options valued at greater than 5% ownership of a publicly traded company or equity of any value in a privately held company)
Other activities: Examples include, but are not limited to, committee participation, data safety monitoring board (DSMB) membership
Scientific Advisory Board:
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