My lab works at the intersection of three areas:
Radiogenetics and Magnetogenetics
We are pioneering the use of radio waves and magnetic fields to stimulate individual cells and neurons - a technique that, like optogenetics, has broad research and therapeutic applications but which is non-invasive.
Nanobioengineering
We are developing the use of nanoparticles in bioengineered murine models for preclinical applications using ferritin and other naturally occurring nanoparticles.
Neuroendocrinology of diabetes
We are advancing the understanding of the interaction between central and peripheral systems in, and beyond, appetite control to find new approaches to Diabetes prevention and treatment.
We are fortunate to work in close collaboration with colleagues across Mount Sinai and in partnerships with Professor Jeffrey Friedman, Rockefeller University, and Professor Jonathan Dordick, Rensselaer Polytechnic Institute. Currently, our work is funded by The National Institutes of Health and American Diabetes Association.
Profile
I studied, trained and practiced as a physician at Cambridge University and London teaching hospitals, including The Royal London and The Hammersmith Hospital. My work combined clinics for diabetes and rare endocrinology issues such as neuroendocrine tumors and pituitary disease with busy Internal Medicine intakes. Although I loved providing patient care, I started to realize that most therapies were inadequate. In search of a bigger impact, I joined Professor Steve Bloom's Lab as a Wellcome fellow and completely my PhD (97-2000) "The role of orexigenic and anorexigenic peptides in the control of hypothalamo-pituitary axes". As a Medical Research Council fellow, I joined Professor Jeffrey Friedman's lab at Rockefeller University in 2005, working on murine models for CNS glucose sensing and later on the development of radio and magnetogenetics.
I joined Sinai to start a new lab in 2014 with joint appointments in Endocrinology and Neuroscience. I believe the most important breakthroughs in medical research come at the intersection of existing fields and Sinai is perfectly set up to enable these collaborations. My lab philosophy is simple - medical research requires both individual acumen and team work - and so I am on the lookout for research assistants and post doctoral scientists who combine personal drive with a real desire to learn in a collaborative setting.
Brain, Diabetes, Molecular Biology, Obesity
BA, University of Cambridge
BChir, University of Cambridge
MB, University of Cambridge
PhD, Imperial College, London University
English
Arthur Burrows Prize (Dermatology)
Darwin Prize in Experimental Natural Sciences
James Anderson Prize (Medicine and Surgery)
Stanley SA, Sauer J, Kane RS, Dordick JS, Friedman JM. Remote regulation of glucose homeostasis in mice using genetically encoded nanoparticles. Nature medicine 2015 Jan; 21(1).
Stanley S, Domingos AI, Kelly L, Garfield A, Damanpour S, Heisler L, Friedman J. Profiling of Glucose-Sensing Neurons Reveals that GHRH Neurons Are Activated by Hypoglycemia. Cell metabolism 2013 Oct; 18(4).
Stanley SA, Gagner JE, Damanpour S, Yoshida M, Dordick JS, Friedman JM. Radio-wave heating of iron oxide nanoparticles can regulate plasma glucose in mice. Science (New York, N.Y.) 2012 May; 336(6081).
Pérez CA, Stanley SA, Wysocki RW, Havranova J, Ahrens-Nicklas R, Onyimba F, Friedman JM. Molecular annotation of integrative feeding neural circuits. Cell metabolism 2011 Feb; 13(2).
McGowan BM, Minnion JS, Murphy KG, White NE, Roy D, Stanley SA, Dhillo WS, Gardiner JV, Ghatei MA, Bloom SR. Central and peripheral administration of human relaxin-2 to adult male rats inhibits food intake. Diabetes, obesity & metabolism 2010 Dec; 12(12).
Stanley S, Pinto S, Segal J, Pérez CA, Viale A, DeFalco J, Cai X, Heisler LK, Friedman JM. Identification of neuronal subpopulations that project from hypothalamus to both liver and adipose tissue polysynaptically. Proceedings of the National Academy of Sciences of the United States of America 2010 Apr; 107(15).
McGowan BM, Stanley SA, Donovan J, Thompson EL, Patterson M, Semjonous NM, Gardiner JV, Murphy KG, Ghatei MA, Bloom SR. Relaxin-3 stimulates the hypothalamic-pituitary-gonadal axis. American journal of physiology. Endocrinology and metabolism 2008 Aug; 295(2).
McGowan BM, Stanley SA, White NE, Spangeus A, Patterson M, Thompson EL, Smith KL, Donovan J, Gardiner JV, Ghatei MA, Bloom SR. Hypothalamic mapping of orexigenic action and Fos-like immunoreactivity following relaxin-3 administration in male Wistar rats. American journal of physiology. Endocrinology and metabolism 2007 Mar; 292(3).
Chaudhri OB, Parkinson JR, Kuo YT, Druce MR, Herlihy AH, Bell JD, Dhillo WS, Stanley SA, Ghatei MA, Bloom SR. Differential hypothalamic neuronal activation following peripheral injection of GLP-1 and oxyntomodulin in mice detected by manganese-enhanced magnetic resonance imaging. Biochemical and biophysical research communications 2006 Nov; 350(2).
McGowan BM, Stanley SA, Smith KL, Minnion JS, Donovan J, Thompson EL, Patterson M, Connolly MM, Abbott CR, Small CJ, Gardiner JV, Ghatei MA, Bloom SR. Effects of acute and chronic relaxin-3 on food intake and energy expenditure in rats. Regulatory peptides 2006 Sep; 136(1-3).
Patel AD, Stanley SA, Murphy KG, Frost GS, Gardiner JV, Kent AS, White NE, Ghatei MA, Bloom SR. Ghrelin stimulates insulin-induced glucose uptake in adipocytes. Regulatory peptides 2006 Mar; 134(1).
McGowan BM, Stanley SA, Smith KL, White NE, Connolly MM, Thompson EL, Gardiner JV, Murphy KG, Ghatei MA, Bloom SR. Central relaxin-3 administration causes hyperphagia in male Wistar rats. Endocrinology 2005 Aug; 146(8).
Stanley SA, Murphy KG, Bewick GA, Kong WM, Opacka-Juffry J, Gardiner JV, Ghatei M, Small CJ, Bloom SR. Regulation of rat pituitary cocaine- and amphetamine-regulated transcript (CART) by CRH and glucocorticoids. American journal of physiology. Endocrinology and metabolism 2004 Sep; 287(3).
Seth A, Stanley S, Jethwa P, Gardiner J, Ghatei M, Bloom S. Galanin-like peptide stimulates the release of gonadotropin-releasing hormone in vitro and may mediate the effects of leptin on the hypothalamo-pituitary-gonadal axis. Endocrinology 2004 Feb; 145(2).
Kong W, Stanley S, Gardiner J, Abbott C, Murphy K, Seth A, Connoley I, Ghatei M, Stephens D, Bloom S. A role for arcuate cocaine and amphetamine-regulated transcript in hyperphagia, thermogenesis, and cold adaptation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003 Sep; 17(12).
Todd JF, Stanley SA, Roufosse CA, Bishop AE, Khoo B, Bloom SR, Meeran K. A tumour that secretes glucagon-like peptide-1 and somatostatin in a patient with reactive hypoglycaemia and diabetes. Lancet (London, England) 2003 Jan; 361(9353).
Small CJ, Liu YL, Stanley SA, Connoley IP, Kennedy A, Stock MJ, Bloom SR. Chronic CNS administration of Agouti-related protein (Agrp) reduces energy expenditure. International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 2003 Apr; 27(4).
Seth A, Stanley S, Dhillo W, Murphy K, Ghatei M, Bloom S. Effects of galanin-like peptide on food intake and the hypothalamo-pituitary-thyroid axis. Neuroendocrinology 2003 Feb; 77(2).
Wren AM, Small CJ, Abbott CR, Jethwa PH, Kennedy AR, Murphy KG, Stanley SA, Zollner AN, Ghatei MA, Bloom SR. Hypothalamic actions of neuromedin U. Endocrinology 2002 Nov; 143(11).
Dhillo WS, Small CJ, Stanley SA, Jethwa PH, Seal LJ, Murphy KG, Ghatei MA, Bloom SR. Hypothalamic interactions between neuropeptide Y, agouti-related protein, cocaine- and amphetamine-regulated transcript and alpha-melanocyte-stimulating hormone in vitro in male rats. Journal of neuroendocrinology 2002 Sep; 14(9).
Dhillo WS, Small CJ, Seal LJ, Kim MS, Stanley SA, Murphy KG, Ghatei MA, Bloom SR. The hypothalamic melanocortin system stimulates the hypothalamo-pituitary-adrenal axis in vitro and in vivo in male rats. Neuroendocrinology 2002 Apr; 75(4).
Stanley SA, Small CJ, Murphy KG, Rayes E, Abbott CR, Seal LJ, Morgan DG, Sunter D, Dakin CL, Kim MS, Hunter R, Kuhar M, Ghatei MA, Bloom SR. Actions of cocaine- and amphetamine-regulated transcript (CART) peptide on regulation of appetite and hypothalamo-pituitary axes in vitro and in vivo in male rats. Brain research 2001 Mar; 893(1-2).
Russell SH, Small CJ, Kennedy AR, Stanley SA, Seth A, Murphy KG, Taheri S, Ghatei MA, Bloom SR. Orexin A interactions in the hypothalamo-pituitary gonadal axis. Endocrinology 2001 Dec; 142(12).
Dhillo WS, Small CJ, Seal LJ, Kim MS, Stanley SA, Murphy KG, Ghatei MA, Bloom SR. The hypothalamic melanocortin system stimulates the hypothalamo-pituitary-adrenal axis in vitro and in vivo in male rats. Neuroendocrinology 2002 Apr; 75(4).
Wren AM, Small CJ, Abbott CR, Dhillo WS, Seal LJ, Cohen MA, Batterham RL, Taheri S, Stanley SA, Ghatei MA, Bloom SR. Ghrelin causes hyperphagia and obesity in rats. Diabetes 2001 Nov; 50(11).
Seal LJ, Small CJ, Dhillo WS, Stanley SA, Abbott CR, Ghatei MA, Bloom SR. PRL-releasing peptide inhibits food intake in male rats via the dorsomedial hypothalamic nucleus and not the paraventricular hypothalamic nucleus. Endocrinology 2001 Oct; 142(10).
Abbott CR, Rossi M, Wren AM, Murphy KG, Kennedy AR, Stanley SA, Zollner AN, Morgan DG, Morgan I, Ghatei MA, Small CJ, Bloom SR. Evidence of an orexigenic role for cocaine- and amphetamine-regulated transcript after administration into discrete hypothalamic nuclei. Endocrinology 2001 Aug; 142(8).
Edwards CM, Stanley SA, Davis R, Brynes AE, Frost GS, Seal LJ, Ghatei MA, Bloom SR. Exendin-4 reduces fasting and postprandial glucose and decreases energy intake in healthy volunteers. American journal of physiology. Endocrinology and metabolism 2001 Jul; 281(1).
Small CJ, Kim MS, Stanley SA, Mitchell JR, Murphy K, Morgan DG, Ghatei MA, Bloom SR. Effects of chronic central nervous system administration of agouti-related protein in pair-fed animals. Diabetes 2001 Feb; 50(2).
Stanley SA, Todd JF, Small CJ, Kim MS, Heath MM, Anand P, Ghatei MA, Bloom SR. The effects of ciliary neurotrophic factor on the hypothalamo-pituitary gonadal axis in vitro in female rats. Journal of neuroendocrinology 2000 Oct; 12(10).
Kim MS, Small CJ, Stanley SA, Morgan DG, Seal LJ, Kong WM, Edwards CM, Abusnana S, Sunter D, Ghatei MA, Bloom SR. The central melanocortin system affects the hypothalamo-pituitary thyroid axis and may mediate the effect of leptin. The Journal of clinical investigation 2000 Apr; 105(7).
Murphy KG, Abbott CR, Mahmoudi M, Hunter R, Gardiner JV, Rossi M, Stanley SA, Ghatei MA, Kuhar MJ, Bloom SR. Quantification and synthesis of cocaine- and amphetamine-regulated transcript peptide (79-102)-like immunoreactivity and mRNA in rat tissues. The Journal of endocrinology 2000 Sep; 166(3).
Kim MS, Rossi M, Abusnana S, Sunter D, Morgan DG, Small CJ, Edwards CM, Heath MM, Stanley SA, Seal LJ, Bhatti JR, Smith DM, Ghatei MA, Bloom SR. Hypothalamic localization of the feeding effect of agouti-related peptide and alpha-melanocyte-stimulating hormone. Diabetes 2000 Feb; 49(2).
Seal LJ, Small CJ, Kim MS, Stanley SA, Taheri S, Ghatei MA, Bloom SR. Prolactin releasing peptide (PrRP) stimulates luteinizing hormone (LH) and follicle stimulating hormone (FSH) via a hypothalamic mechanism in male rats. Endocrinology 2000 May; 141(5).
Stanley SA, Small CJ, Kim MS, Heath MM, Seal LJ, Russell SH, Ghatei MA, Bloom SR. Agouti related peptide (Agrp) stimulates the hypothalamo pituitary gonadal axis in vivo & in vitro in male rats. Endocrinology 1999 Nov; 140(11).
Todd JF, Small CJ, Akinsanya KO, Stanley SA, Smith DM, Bloom SR. Galanin is a paracrine inhibitor of gonadotroph function in the female rat. Endocrinology 1998 Oct; 139(10).
Rossi M, Kim MS, Morgan DG, Small CJ, Edwards CM, Sunter D, Abusnana S, Goldstone AP, Russell SH, Stanley SA, Smith DM, Yagaloff K, Ghatei MA, Bloom SR. A C-terminal fragment of Agouti-related protein increases feeding and antagonizes the effect of alpha-melanocyte stimulating hormone in vivo. Endocrinology 1998 Oct; 139(10).
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Dr.Stanley did not report having any of the following types of financial relationships with industry during 2015 and/or 2016: consulting, scientific advisory board, industry-sponsored lectures, service on Board of Directors, participation on industry-sponsored committees, equity ownership valued at greater than 5% of a publicly traded company or any value in a privately held company. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.
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