M. Cecilia Berin
- ASSOCIATE PROFESSOR Pediatrics
BSc(Hons), Queen's University
MSc, Queen's University
PhD, McMaster University
Postdoctoral, University of California, San Diego
ResearchOur laboratory is dedicated to understanding the mucosal immunology of food allergic disorders. Themes within this work include (1) understanding mechanisms responsible for development of sensitization and tolerance to food proteins, (2) determining how allergen-specific T cells home to the gut and induce disease, and (3) finding methods to modify the allergen-specific T cell response for therapeutic purposes. Much of our lab’s work to date has focused on the communication between gastrointestinal epithelial cells, dendritic cells, and antigen-specific T cells in the context of food allergy.
Tordesillas L, Goswami R, Benede S, Grishina G, Dunkin D, Jarvinen KM, Maleki SJ, Sampson HA, Berin MC. Skin exposure promotes a Th2-dependent sensitization to peanut allergens. The Journal of clinical investigation 2014 Oct;.
Berin MC, Wang W. Reduced severity of peanut-induced anaphylaxis in TLR9-deficient mice is associated with selective defects in humoral immunity. Mucosal immunology 2012 Jun;.
Leonard SA, Martos G, Wang W, Nowak-Węgrzyn A, Berin MC. Oral immunotherapy induces local protective mechanisms in the gastrointestinal mucosa. The Journal of allergy and clinical immunology 2012 Jun; 129(6).
Berin MC, Sicherer S. Food allergy: mechanisms and therapeutics. Current opinion in immunology 2011 Dec; 23(6).
Dunkin D, Berin MC, Mayer L. Allergic sensitization can be induced via multiple physiologic routes in an adjuvant-dependent manner. The Journal of allergy and clinical immunology 2011 Dec; 128(6).
Blázquez AB, Mayer L, Berin MC. Thymic stromal lymphopoietin is required for gastrointestinal allergy but not oral tolerance. Gastroenterology 2010 Oct; 139(4).
Blázquez AB, Knight AK, Getachew H, Bromberg JS, Lira SA, Mayer L, Berin MC. A functional role for CCR6 on proallergic T cells in the gastrointestinal tract. Gastroenterology 2010 Jan; 138(1).
Berin MC, Mayer L. Immunophysiology of experimental food allergy. Mucosal immunology 2009 Jan; 2(1).
Berin MC, Shreffler WG. T(H)2 adjuvants: implications for food allergy. The Journal of allergy and clinical immunology 2008 Jun; 121(6).
Blázquez AB, Berin MC. Gastrointestinal dendritic cells promote Th2 skewing via OX40L. Journal of immunology (Baltimore, Md. : 1950) 2008 Apr; 180(7).
Li H, Chehade M, Liu W, Xiong H, Mayer L, Berin MC. Allergen-IgE complexes trigger CD23-dependent CCL20 release from human intestinal epithelial cells. Gastroenterology 2007 Dec; 133(6).
Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.
Dr. Berin did not report having any of the following types of financial relationships with industry during 2013 and/or 2014: consulting, scientific advisory board, industry-sponsored lectures, service on Board of Directors, participation on industry-sponsored committees, equity ownership valued at greater than 5% of a publicly traded company or any value in a privately held company. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.
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