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Lisa Satlin

  • PROFESSOR AND SYSTEM CHAIR Pediatrics
  • PROFESSOR Medicine, Nephrology
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Certifications

  • Pediatric Nephrology

  • American Board of Pediatrics

Clinical Focus

  • Electrolyte problems, acidosis
  • Genetic kidney diseases
  • Hypertension (high blood pressure)
  • Kidney cysts

Education

  • MD, Columbia Univ. Col. of Phy. & Surg.

  • Residency, Pediatrics
    Columbia-Presbyterian Medical Ctr.

  • Fellowship, Nephrology
    Albert Einstein College of Medicine

Biography

    Lisa Satlin is the Herbert H. Lehman Professor of Pediatrics and Chair of the Department at the Icahn School of Medicine at Mount Sinai (ISMMS), where she is also an Associate Director of the MD/PhD Training Program. She received her MD degree from Columbia University College of Physicians and Surgeons, and completed a residency in Pediatrics at the Babies Hospital of Columbia University and a Pediatric Nephrology Fellowship at the Albert Einstein College of Medicine. At the ISMMS, as Chief of the Division of Pediatric Nephrology (1997-2010), Dr. Satlin built an internationally respected academic division and an ACGME-accredited Pediatric Nephrology Fellowship training program, which has attracted both physician and research trainees interested in clinical nephrology and basic/translational research related to developmental nephrology, respectively. She continues to run an active NIH-supported laboratory, supported in part to serve as a national “Single Tubule Physiology Core” as part of an O’Brien Renal Research Center, focused on defining the mechanisms leading to the acquisition, maintenance and regulation of transepithelial transport in the renal collecting duct, the nephron segment responsible in the adult for the final regulation of salt and water homeostasis. Her research accomplishments have been recognized by her election to membership in the Society for Pediatric Research, the American Pediatric Society, and the Association of American Physicians.

    Dr. Satlin has served as President of the American Society of Pediatric Nephrology and Councilor of the International Pediatric Nephrology Association. She just completed her second term as Associate Editor of the American Journal of Physiology: Renal Physiology, and has participated in many study sections and grant-review groups for the NIH and the American Heart Association.

Awards

  • 2013 -
    Selected as the Hans Ussing Lecturer, American Physiological Society, Annual Meeting of the Federation of American Societies for Experimental Biology
    American Physiological Society

  • 2013 -
    Jacobi Medallion Recipient
    Mount Sinai

  • 2012 -
    Recipient of the J. Lester Gabrilove Award
    Mount Sinai

  • 2011 -
    KUFA National Medal Award in Pediatric Nephrology
    The Kidney & Urology Foundation of America

  • 2008 - 2013
    New York Super Doctors
    Castle Connolly

  • 2006 - 2012
    New York Metro Area Top Doctor (Castle Connolly)
    Castle Connolly

  • 2003 - present
    Best Doctors in America (New York Magazine)
    New York Magazine

Research

The focus of the Satlin lab is on defining the mechanisms leading to the acquisition, maintenance and regulation of transepithelial transport in the mammalian cortical collecting duct, a nephron segment responsible in the adult for the final renal regulation of total body potassium (K) and sodium (Na) homeostasis. Specifically, her lab continues to expand on two major discoveries: (1) unique developmental programs underlying the postnatal expression of ion channels responsible for Na absorption (ENaC) and K secretion (SK/ROMK and calcium/flow-activated BK channels) in this epithelium, thus establishing the physiological basis for total body Na and K retention required for somatic growth and maintenance of blood pressure, and (2) the role of variations in urinary flow rate (i.e., hydrodynamic forces) in mechanoregulation of renal epithelial ion channels in health and disease.  As the lab serves as a national "Single Nephron Physiology" Core of an NIH-funded O'Brien Center for Kidney Research, techniques available to Core users include in vitro microperfusion of single nephron segments, fluorescent functional imaging of single cells in native tissue or cultured epithelia (for measurement of cell pH, calcium, K and Na), patch clamp studies of single cells for electrophysiologic analysis of channel activity, and molecular/biochemical techniques applied to single cells and tubules.

Publications

Wang Z, Subramanya A, Satlin L, Pastor-Soler N, Carattino M, Kleyman T. Regulation of large conductance Ca2+ - activated K+ channels by WNK4 kinase. Am J Physiol Cell Physiol July; 2013.

Flores D, Liu Y, Liu W, Satlin LM, Rohatgi R. Flow induced prostaglandin E2 release regulates Na and K transport in the collecting duct . American Journal of Physiology Renal Physiology 2012; 303: F632-F638.

Liu W, Pastor-Soler NM, Schreck C, Zavilowitz B, Kleyman TR, Satlin LM. Luminal flow modulates H+-ATPase activity in the cortical collecting duct (CCD). Am. J. Physiol. Renal Physiol. 2012 Jan; 302(1): F205-F215.

Liu W, Schreck C, Coleman RA, Wade JB, Hernandez Y, Zavilowitz B, Warth R, Kleyman TR, Satlin LM. Role of NKCC1 in BK channel-mediated net K secretion in the CCD. Am. J. Physiol. Renal Physiol. 2011 August; 301: F1088-F1097.

Carrisoza-Gaytan R, Saldana-Meyer R, Rangel C, Salvador C, Escalona C, Satlin L, Liu W, Zavilowitz B, Trujillo J, Bobadilla N, Escobar LI. A pathway for ammonium transport in the rat kidney: the hyperpolarization-activated cyclic nucleotide-gated HCN2 channel. Kidney Int. 2011 July; 80: 832-840.

Weinbaum S, Duan Y, Satlin LM, Wang T, Weinstein A. Mechanotransduction in the renal tubule. Am J Physiol Renal Physiol 2010 Dec; 299(6): 220-236.

Liu W, Wei Y, Sun P, Wang WH, Kleyman TR, Satlin LM. Mechanoregulation of BK channel activity in the mammalian cortical collecting duct (CCD): role of protein kinases A and C. Am. J. Physiol. Renal Physiol. 2009; 297: F904-F915.

Sun P, Liu W, Lin DH, Yue P, Kemp R, Satlin LM, Wang WH. Epoxyeicosatrienoic acid activates BK channels in the cortical collecting duct. J. Am. Soc. Nephrol 2009; 20: 513-523.

Estilo G, Liu W, Pastor-Soler N, Mitchell P, Kleyman T, Satlin LM. Effect of mineralocorticoids on maxi-K channel expression in the cortical collecting duct (CCD). Am. J. Physiol. Renal Physiol 2008; 295: F780-F788.

Rohatgi R, Battini L, Kim P, Israel S, Wilson PD, Gusella GL, Satlin LM. Mechanoregulation of intracellular Ca2+ in human autosomal recessive polycystic kidney disease (ARPKD) cyst-lining renal epithelial cells. Am J Physiol Renal Physiol 2008; 294: F890-F899.

Carattino MD, Liu W, Hill W, Satlin LM, Kleyman TR. Lack of a role of membrane-protein interactions in flow-dependent activation of ENaC. Am. J. Physiol. Renal Physiol. 2007; 293: F316-F324.

Liu W, Morimoto T, Woda C, Kleyman TR, Satlin LM. Ca2-dependence of flow-stimulation of K secretion in the mammalian collecting duct. Am J Physiol Renal Physiol 2007; 293: F227-F235.

Satlin LM, Carattino M, Liu W, Kleyman TR. Regulation of cation transport in the distal nephron by mechanical forces. Am J Physiol 2006; 291: F923-F931.

Morimoto T, Liu W, Woda C, Carattino MS, Wei Y, Hughey RP, Apodaca G, Satlin* LM, Kleyman TR. Mechanism underlying flow-stimulation of Na absorption in the mammalian collecting duct (* corresponding author). Am J Physiol 2006; 291: F663-F669.

Liu W, Murcia NS, Duan Y, Weinbaum S, Yoder BK, Schwiebert E, Satlin LM. Mechanoregulation of intracellular Ca2+ concentration is attenuated in collecting duct of monocilium-impaired orpk mice. Am J Physiol Renal Physiol 2005; 289: F978-F988.

Najjar F, Zhou H, Morimoto T, Satlin LM, Li HS, Liu W, Kleyman TR, Bruns JB. Dietary K+ regulates apical membrane expression of maxi-K channels in rabbit cortical collecting duct. Am J Physiol Renal Physiol 2005; 289: 922-932.

Liu W, Xu S, Woda C, Kim P, Weinbaum S, Satlin LM. Effect of flow and stretch on the [Ca2+]i response of principal and intercalated cells in cortical collecting duct. Am. J. Physiol. 2003 Nov; 285(5): F998-F1012.

Woda CB, Miyawaki N, Ramalakshmi S, Zavilowitz B, Kleyman TR, Satlin LM. Ontogeny of flow-stimulated potassium secretion in rabbit cortical collecting duct: functional and molecular aspects. Am. J. Physiol. Renal 2003; 285: F629-F639.

Satlin LM, Sheng S, Woda CB, Kleyman TR. Epithelial sodium channels are regulated by flow. Am. J. Physiol. 2001 Jun; 280(6): F1010-F1018.

Woda CB, Bragin A, Kleyman TR, Satlin LM. Flow-dependent K+ secretion in the cortical collecting duct is mediated by a maxi-K channel. Am. J. Physiol. 2001 May; 280(5): F786-F793.

Industry Relationships

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.

Dr. Satlin did not report having any of the following types of financial relationships with industry during 2013 and/or 2014: consulting, scientific advisory board, industry-sponsored lectures, service on Board of Directors, participation on industry-sponsored committees, equity ownership valued at greater than 5% of a publicly traded company or any value in a privately held company. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website at http://icahn.mssm.edu/about-us/services-and-resources/faculty-resources/handbooks-and-policies/faculty-handbook. Patients may wish to ask their physician about the activities they perform for companies.

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