Research in the Costa Laboratory is focused on understanding how biomechanical factors impact cardiovascular cell and tissue function in healthy and diseased states. Sophisticated computational modeling is combined with state-of-the-art experimental methods to attack this challenging multi-scale problem. Atomic force microscopy (AFM) is used to probe the micro-scale viscoelastic mechanobiological response of living cells and tissue samples. Novel engineered tissues and organoids are created for investigating mechanisms of cardiovascular remodeling, injury, repair, and regeneration. These living model systems allow unprecedented control of tissue composition, structure, and geometry combined with advantages of long-term viability and high-throughput therapeutic screening capability. An emphasis on human-derived cell sources helps to ensure clinically translatable outcomes from modulating patient-specific cardiovascular niche environments, ultimately helping to transform the fields of tissue engineering, cardiology, and personalized regenerative medicine.
Dr. Costa has received research funding from the Whitaker Foundation, the National Science Foundation (NSF) and the National Institutes of Health (NIH; NHLBI, NIBIB, and NIGMS). He was a recipient of the prestigious Faculty Early Career Development (CAREER) Award from the NSF, and has served on the Editorial Boards for Biophysical Journal and the new journal Molecular and Cellular Bioengineering.
Biomechanics/Bioengineering, Cardiovascular, Cellular Differentiation, Computer Simulation, Cytoskeleton, Mathematical Modeling of Biomedical Systems, Muscle Cells, Regeneration, Stem Cells, Tissue Engineering, Wound Healing
Multi-Disciplinary Training Areas
Biophysics and Systems Pharmacology [BSP], Developmental and Stem Cell Biology [DSCB]
MS, Boston University
PhD, University of California, San Diego
Tissue Engineering And Cardiac Repair
This research involves development of innovative new tools and approaches combining soft lithography, cell patterning, and bioreactor design for tissue and organoid engineering, with the overall objective of improving the understanding and efficacy of novel cell- and gene-therapy based approaches for cardiac repair.
Atomic Force Microscopy And Cell Mechanobiology
This research is focused on enhancing and expanding the kinds of measurements that can be obtained from AFM mechanical testing experiments, to better understand how physical forces impact cardiovascular cell function.
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Dr. Costa has not yet completed reporting of Industry relationships.
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