Isabelle M. Germano

PROFESSOR Neurosurgery
PROFESSOR Oncological Sciences
PROFESSOR Neurology

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isabelle.germano@mountsinai.org

Specialty

Neurological Surgery

Certifications

Neurological Surgery

Clinical Focus

Education

MD, University of Turin Medical School
Residency, Neurosurgery
Albert Einstein College of Medicine
Residency, Surgery
Univ. of California, San Francisco
Residency, Neurosurgery
Univ. of California, San Francisco
Fellowship, Neurosurgery
Montreal Neurological Institute
Fellowship, Neurosurgery
University of Zurich

Awards

2008 - 2012
Research grant: Brain tumors and gene transfer
National Institute of Health
2007
Brain Tumor Research
Goldhirsh Foundation
2006
Life Time Member
Who is Who Strathmore's
2006
New York State Certificats of Recognition, Dedication and Service to the Italians Culture and Community
New York State
2005
Certificate of Excellence in Youth Education
New York City Department of Education and Mount Sinai School of Medicine
2004
Neurosurgery Research Award
New York State Society
2002 - 2006
America's Top Cancer Doctors
Castle Connolly
2000 - 2006
America's Top Doctors 1-5th edition
Castle Connolly
2000 - 2006
Best Doctors Of New York
New York Magazine
2000 - 2006
Top Doctors New York Metro Area
Castle Connolly
1994
Mary Putnam Jacobi Award
Women's Medical Association of New York City
1993
W. Penfield Award
American Epilepsy Society

Biography

Dr. Germano joined the faculty at Mount Sinai in 1993. Her specialty interests include Brain Tumors, Computer-Assisted Image-Guided Neurosurgery, Parkinson's disease and Movement Disorders, Epilepsy and Radiosurgery. She is Director of The Mount Sinai Medical Center Stereotactic and Brain Tumor Program, an advanced multidisciplinary program based on computer-assisted image-guided neurosurgery and brain mapping to accomplish minimally invasive procedures and treatment of brain tumors. Dr. Germano is one of the pioneers of computer-assisted image-guided neurosurgery. This sophisticated technology, including the Novalis Shaped Beam Surgery, is used to perform minimally invasive surgery for patients with brain tumors, epilepsy, Parkinson's disease and movement disorders. Active in national neurosurgery organizations, she has served as an executive committee member for the Congress of Neurosurgery (CNS), as a Board of Directors' member for the American Association of Neurological Surgeons, as an executive committee member of the AANS/CNS Joint Section on Tumors, and as a scientific program member for the AANS, CNS, and the American Epilepsy Society. For the past five years she has directed a course, Advanced Techniques in Image-Guided Brain and Spine Surgery, for neurosurgeons from around the country.In the News

Dr. Germano and her work diagnosing and treating brain tumors were recently profiled in The Daily News feature The Daily Check Up. View the PDF.

Research

Translational research for malignant brain tumors
The main focus of the laboratory is to investigate new strategies for adjuvant treatment of malignant brain tumors. With the support from the National Institutes of Health, NIH, private foundations and Industry, the laboratory has been very productive in investigating new promising modalities and compound to kill brain tumor cells. Embryonic stem cells are currently used in animal models to transfer genes to brain tumors.

Image-guide computer-assisted neurosurgery
One of the pioneers in this field, Dr. Germano continues to collaborate with the industry in making neurosurgical resections more accurate and less invasive.

Related Link:
Brain Tumor and Gene Therapy Laboratory

Publications

Germano IM, Emdad L, Qadeer ZA, Binello E, Uzzaman M. Embryonic stem cell (ESC)-mediated transgene delivery induces growth suppression, apoptosis and radiosensitization, and overcomes temozolomide resistance in malignant gliomas.. Cancer Gene Ther 2010 Jun;: Epub ahead.

Roberts CC, Daffner RH, Weissman BN, Bancroft L, Bennett DL, Blebea JS, Bruno MA, Fries IB, Germano IM, Holly L, Jacobson JA, Luchs JS, Morrison WB, Olson JJ, Payne WK, Resnick CS, Schweitzer ME, Seeger LL, Taljanovic M, Wise JN, Lutz ST. ACR appropriateness criteria on metastatic bone disease.. J Am Coll Radiol 2010 Jun; 7(6): 400-409.

Videtic GM, Gaspar LE, Aref AM, Germano IM, Goldsmith BJ, Imperato JP, Marcus KJ, McDermott MW, McDonald MW, Patchell RA, Robins HI, Rogers CL, Suh JH, Wolfson AH, Wippold FJ. American College of Radiology Appropriateness Criteria® topic, Multiple Brain Metastases. J Radiation Oncology Biology Physics 2009 Nov; 75(4): 961-965.

Binello E, Germano IM. Tonsillary carcinoma after temozolomide treatment for glioblastoma multiforme: treatment-related or dual-pathology?. J Neurooncol 2009 Aug; 94(1): 145-148.

Germano IM, Binello E. Gene therapy as an adjuvant treatment of malignant gliomas: from bench to bedside. J Neuro-Oncology 2009 May; 93(1): 79-87.

Uzzaman M, Keller G, Germano IM. In vivo Gene Delivery by embryonic stem cell-derived astrocytes for malignant gliomas. Neuro-Oncology 2009 Apr; 11(2): 102-108.

Gonzales A, Sullivan G, Sips GJ, Naidich T, Kleinman G, Murray J, Morgello S, Germano IM, Mullen M, Simpson D. . Inflammatory Pseudotumor associated with HIV-JCV an immune-reconstruction syndrome. Neurology 2009 Jan; 72(3): 289-290.

Benzil D, Abosch A, Germano IM, Gilmer H, Maraire N, Muraszko K, Pannullo S, Rosseau G, Schwartz L, Todor R, Ullman J, Zusman E. The future of neurosurgery: a white paper on the recruitment and retention of women in neurosurgery. J Neurosurgery 2008 Sept; 109(3): 378-386.

Germano IM, Uzzaman M, Keller G. Gene delivery by embryonic stem cells for malignant gliomas. Cancer Biology and Therapy 2008 Sept; 7(9): 1341-1347.

Uzzaman M, Keller G, Germano I. In vivo Gene Delivery by embryonic stem cell-derived astrocytes for malignant gliomas. Neuro-Oncology 2008 Apr; 11(2): 102-108.

Uzzaman M, Keller G, Germano IM. Enhanced pro-apotptotic effects of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) on temozolomide-resistant glioma cells. J Neurosurgery 2007 Apr; 106(4): 646-651.

Germano I, Uzzaman M, Benveniste R, Zaurova M, Keller G. Apoptosis in human glioma cells produced using embryonic stem cell-derived astrocytes expressing tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). J Neurosurgery 2006 July; 105(1): 88-95.

Uzzaman M, Benveniste R, Keller G, Germano IM. Embryonic stem cell-derived astrocytes: novel gene therapy vector for brain tumors. Neurosurgical Focus 2005 Sept; 19(3): E6.

Benveniste R, Keller G, Germano IM. Embryonic stem cell-derived astrocytes expressing drug-inducible transgenes: Differentiation and allotransplantation into the mouse brain. J Neurosurgery 2005 July; 103(1): 115-123.

Benveniste R, Germano IM. Correlation of factors predicting intraoperative brain shift with successful resection of malignant brain tumors using image-guided techniques. Surg Neurol 2005 June; 63(6): 542-549.

Kanzawa T, Zhang L, Xiao L, Germano IM, Kondo Y, Kondo S. Arsenic trioxide induces autophagic cell death in malignant glioma cells by up-regulation of mitochondrial cell death protein BNIP3. Oncogene 2005 June; 24(6): 980-991.