Psychiatry, American Board of Psychiatry and Neurology
Addiction, Behavior, Depression, Epigenetics, Molecular Biology, Neuroscience, Synapses, Synaptic Plasticity, Synaptogenesis
Biophysics and Systems Pharmacology [BSP], Neuroscience [NEU]
MD, Yale University School of Medicine
PhD, Yale University
Yale University School of Medicine
Yale University School of Medicine
Yale University School of Medicine
Sarnat Prize, Institute of Medicine
American Academy of Arts and Science
Institute of Medicine
Nestler Lab, Laboratory of Molecular Psychiatry
Specific Clinical/Research Interest: Molecular neurobiology of drug addiction and depression; transcriptional and epigenetic regulation in the brain.
Current Students: Hannah Cates, Hope Kronman, Casey Lardner, Efrain Ribeiro, Zach Lorsch
Postdoctoral Fellows: Rosemary Bagot, Michael Cahill, Erin Calipari, Olivia Engmann, Peter Hamilton, Orna Issler, Benoit Labonte, Catherine Peña, Deena Walker
Research Personnel: Zeke Mouzon (Lab Manager), Dominika Burek, Nicolle Strat
Our research focuses on identifying the neurobiological basis of drug addiction and depression in rodent models. We study the molecular and cellular changes that occur in regions of the brain important for reward and motivation in response to chronic administration of a drug of abuse or chronic exposure to stress. We are particularly interested in long-lasting changes that are mediated via alterations in gene expression and chromatin remodeling. The result of the research will guide future efforts toward the development of more effective treatments for addiction and depression.
For more, please visit Selected Publications:
Heller EA, Cates HM, Peña CJ, Sun H, Shao N, Feng J, Golden SA, Herman JP, Walsh JJ, Mazei-Robison M, Ferguson D, Knight S, Gerber MA, Nievera C, Han MH, Russo SJ, Tamminga CS, Neve RL, Shen L, Zhang HS, Zhang F, Nestler EJ. Locus-specific epigenetic remodeling controls addiction- and depression-related behaviors. Nature neuroscience 2014 Dec; 17(12).
Dias C, Feng J, Sun H, Shao NY, Mazei-Robison MS, Damez-Werno D, Scobie K, Bagot R, LaBonté B, Ribeiro E, Liu X, Kennedy P, Vialou V, Ferguson D, Peña C, Calipari ES, Koo JW, Mouzon E, Ghose S, Tamminga C, Neve R, Shen L, Nestler EJ. β-catenin mediates stress resilience through Dicer1/microRNA regulation. Nature 2014 Nov;.
Maze I, Shen L, Zhang B, Garcia BA, Shao N, Mitchell A, Sun H, Akbarian S, Allis CD, Nestler EJ. Analytical tools and current challenges in the modern era of neuroepigenomics. Nature neuroscience 2014 Nov; 17(11).
Bagot RC, Labonté B, Peña CJ, Nestler EJ. Epigenetic signaling in psychiatric disorders: stress and depression. Dialogues in clinical neuroscience 2014 Sep; 16(3).
Dong Y, Nestler EJ. The neural rejuvenation hypothesis of cocaine addiction. Trends in pharmacological sciences 2014 Aug; 35(8).
Mitchell AC, Bharadwaj R, Whittle C, Krueger W, Mirnics K, Hurd Y, Rasmussen T, Akbarian S. The genome in three dimensions: a new frontier in human brain research. Biological psychiatry 2014 Jun; 75(12).
Shen L, Shao N, Liu X, Nestler E. ngs.plot: Quick mining and visualization of next-generation sequencing data by integrating genomic databases. BMC genomics 2014; 15.
Maze I, Noh KM, Soshnev AA, Allis CD. Every amino acid matters: essential contributions of histone variants to mammalian development and disease. Nature reviews. Genetics 2014 Apr; 15(4).
Maze I, Chaudhury D, Dietz DM, Von Schimmelmann M, Kennedy PJ, Lobo MK, Sillivan SE, Miller ML, Bagot RC, Sun H, Turecki G, Neve RL, Hurd YL, Shen L, Han MH, Schaefer A, Nestler EJ. G9a influences neuronal subtype specification in striatum. Nature neuroscience 2014 Apr; 17(4).
Vialou V, Bagot RC, Cahill ME, Ferguson D, Robison AJ, Dietz DM, Fallon B, Mazei-Robison M, Ku SM, Harrigan E, Winstanley CA, Joshi T, Feng J, Berton O, Nestler EJ. Prefrontal cortical circuit for depression- and anxiety-related behaviors mediated by cholecystokinin: role of ΔFosB. The Journal of neuroscience : the official journal of the Society for Neuroscience 2014 Mar; 34(11).
Scobie KN, Damez-Werno D, Sun H, Shao N, Gancarz A, Panganiban CH, Dias C, Koo J, Caiafa P, Kaufman L, Neve RL, Dietz DM, Shen L, Nestler EJ. Essential role of poly(ADP-ribosyl)ation in cocaine action. Proceedings of the National Academy of Sciences of the United States of America 2014 Feb; 111(5).
Feng J, Wilkinson M, Liu X, Purushothaman I, Ferguson D, Vialou V, Maze I, Shao N, Kennedy P, Koo J, Dias C, Laitman B, Stockman V, LaPlant Q, Cahill ME, Nestler EJ, Shen L. Chronic cocaine-regulated epigenomic changes in mouse nucleus accumbens. Genome biology 2014; 15(4).
Koo JW, Mazei-Robison MS, Chaudhury D, Juarez B, LaPlant Q, Ferguson D, Feng J, Sun H, Scobie KN, Damez-Werno D, Crumiller M, Ohnishi YN, Ohnishi YH, Mouzon E, Dietz DM, Lobo MK, Neve RL, Russo SJ, Han MH, Nestler EJ. BDNF is a negative modulator of morphine action. Science (New York, N.Y.) 2012 Oct; 338(6103).
Dietz DM, Sun HS, Lobo MK, Cahill ME, Nestler EJ, Chadwick B, Gao V, Koo JW, Mazei-Robison MS, Dias C, Maze I, Damez-Werno D, Dietz KC, Scobie KN, Ferguson D, Christofell D, Ohnishi Y, Hodes GE, Zheng Y, Neve RL, Hahn KM, Russo RJ, Nestler EJ. Essential for Rac1 in cocaine-induced structure plasticity of nucleus accumbens neurons.. Nat Neurosci 2012; 15: 891-896.
Lobo MK, Covington HE, Chaudhury D, Friedman AK, Sun HS, Damez-Werno D, Dietz D, Zaman S, Koo JW, Kennedy PJ, Mouzon E, Mogri M, Neve RL, Deisseroth K, Han MH, Nestler EJ. Cell type specific loss of BDNF signaling mimics optogenetic control of cocaine reward. Science 2010; 330: 385-390.
Maze I, Covington HE, Dietz DM, LaPlant Q, Renthal W, Russo SJ, Mechanic M, Mouzon E, Neve RL, Haggarty SJ, Ren YH, Sampath SC, Hurd YL, Greengard P, Tarakovsky A, Schaefer A, Nestler EJ. Essential role of the histone methyltransferase G9a in cocaine-induced plasticity. Science 2010; 327: 213-216.
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Below are financial relationships with industry reported by Dr. Nestler during 2015 and/or 2016. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.
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