(PHP; Underactive Pituitary Gland)
The pituitary gland is found at the base of the brain. It produces several important hormones that control the production of other hormones made by glands in the body. In panhypopituitarism, the gland produces an insufficient amount of hormones.
This condition is most often caused by damage to the gland. In adults, it is usually a result of pituitary surgery. In children, damage to the pituitary gland may be caused by:
In some cases, the cause may be unknown.
Factors that may increase your chance of panhypopituitarism include:
Compression of the Tumor
Compression of the tumor on local structures, especially the nerves of the eyes, can cause:
- Blurred vision
- Loss of visual field
- Poor temperature control
Insufficient levels of gonadotropins
- In premenopausal women—missed menstrual cycles, infertility, osteoporosis, vaginal dryness, loss or reduction in female characteristics
- In men—impotence, reduced size of testes, decreased production of sperm, infertility, breast enlargement, reduced muscle mass, loss or reduction in male characteristics like beard growth
Insufficient levels of growth hormone
- In children—stunted growth or dwarfism
- In adults—weakness, obesity, reduced cardiac output, low blood sugar levels, and reduced exercise tolerance
- Insufficient levels of thyroid-stimulating hormones can lead to:
Insufficient corticotrophic levels
can lead to:
- Underactive adrenal gland, which causes low blood pressure, low blood sugar, fatigue, weight loss, vomiting, and low stress tolerance (this can be life-threatening).
Excessive prolactin levels
- In women—missed periods, infertility, and milk secretion
- In men—reduced facial and body hair, small testes
- Insufficient antidiuretic hormone (rare) can cause:
- Excessive thirst and frequent urination
- Night-time urination
Your doctor will ask about your symptoms and medical history. A physical exam will be done.
Tests may include the following:
- Blood tests—to measure pituitary, as well as target gland hormone levels
- Stimulation tests—to test the maximum capacity of the endocrine glands, usually of the pituitary gland
- Semen analysis—in males suspected of infertility
- MRI scan—imaging test used to assess internal structures
Talk with your doctor about the best plan for you. Treatment depends on the cause of the condition. The goal of treatment is to restore normal blood hormone levels of thyroid, adrenal, estrogen or testosterone, and sometimes growth hormone.
Treatment options include:
- Hormone replacement therapy—based on what types of hormones are missing
- Tumor removal—done if the cause of the damage is a tumor
- Radiation therapy—done if the cause of the damage is a cancer or tumor
In most cases, the causes of panhypopituitarism are not preventable.
Hormone Health Network—Endocrine Society
The Pituitary Network Association
About Kids Health—The Hospital for Sick Children
Bhasin S, Cunningham GR, et al. Testosterone therapy in adult men with androgen deficiency syndromes: an endocrine society clinical practice guideline. J Clin Endocrinol Metab. 2006;91:1995-2010.
Hypopituitarism in children. Lucile Packard Children's Hospital website. Available at: http://www.lpch.org/DiseaseHealthInfo/HealthLibrary/diabetes/hypop.html. Accessed February 6, 2015.
Randeva HS, Schoebel J, et al. Classical pituitary apoplexy: clinical features, management and outcome. Clin Endocrinol (Oxf). 1999;51:181-188.
Schneider HJ, Aimaretti G, et al. Hypopituitarism. Lancet. 2007;269:1461-1470.
Toogood AA, Stewart PM. Hypopituitarism: clinical features, diagnosis, and management. Endocrinol Metab Clin North Am. 1998;37:235-261
What is a growth disorder? Nemours Kids Health website. Available at: http://kidshealth.org/parent/medical/endocrine/growth_disorder.html. Updated July 2014. Accessed February 6, 2015.
Last reviewed February 2015 by Kim Carmichael, MD
Please be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition.