Tumor - adrenal
Adrenocortical carcinoma is a cancer of the
Adrenocortical carcinoma is most common in children younger than 5 years old and adults in their 30s and 40s.
The condition may be linked to a cancer syndrome that is passed down through families (inherited). Both men and women can develop this tumor.
Adrenocortical carcinoma can produce the hormones cortisol, aldosterone, estrogen, or testosterone, as well as other hormones. In women the tumor often releases these hormones, which can lead to male characteristics.
Adrenocortical carcinoma is very rare. The cause is unknown. About 2 people per million develop this type of tumor.
Symptoms of increased cortisol or other adrenal gland hormones:
Symptoms of increased aldosterone are the same as symptoms of low potassium, and include:
The doctor or nurse will examine you. You may have high blood pressure and changes in body shape, such as breast growth in men (gynecomastia) or male signs in women (virilization). Blood tests will be done to check hormone levels:
Imaging tests may include:
Primary treatment is surgery to remove the tumor. Adrenocortical carcinoma may not improve with
The outcome depends on how early the diagnosis is made and whether the tumor has spread (metastasized). Tumors that have spread usually lead to death within 1 to 3 years.
The tumor can spread to the liver, bone, lung, or other areas.
Call your health care provider if you or your child has symptoms of adrenocortical carcinoma,
National Comprehensive Cancer Network. National Comprehensive Cancer Network Clinical Practice Guidelines in Oncology: Neuroendocrine tumors. 2012. Version 1.2012.
Nieman LK. Adrenal cortex. In: Goldman L, Schafer AI, eds. Goldman's Cecil Medicine. 24th ed. Philadelphia, PA: Elsevier Saunders; 2011:chap 234.
Last reviewed on: 8/31/2014
Reviewed by: Yi-Bin Chen, MD, Leukemia/Bone Marrow Transplant Program, Massachusetts General Hospital, Boston, MA. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team.