Research Frontiers

The Mount Sinai neuromuscular division is involved in the following research:

  • Assessment of Autonomic Function in a Low-Income Urban Patient Population
    This study assesses the validity of a questionnaire, “The Composite Autonomic Symptom Scale (COMPASS),” in determining the presence of autonomic dysfunction in a diverse inner-city population.
  • The Effect of Diflunisal on Familial Amyloidosis
    This randomized, double-blind, placebo-controlled, international multicenter trial is determining the effect of diflunisal on neurologic disease progression in 200 familial amyloid patients.
  • The Experience of Chronic Pain: A Focus Group Approach
    This study explores how patients with chronic pain, including diabetic and HIV-associated neuropathy, experience their symptoms, with the goal of improving communication between patients and providers.
  • A Multi-Center, Single-Blind, Randomized Study Comparing Thymectomy to No Thymectomy in Non-Thymomatous Myasthenia Gravis (MG) Patients Receiving Prednisone
  • A Randomized, Double-Blind, Placebo-Controlled, Cross-Over, Multi-Center study for Eculizumab in Patients with Generalized Myasthenia Gravis (GMG) Who Have Moderate to Severe Muscle Weakness Despite Treatment with Immunosuppressants
    This study investigates the effectiveness of a new treatment, eculizumab, for patients with myasthenia gravis.
  • A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Multicenter Trial of Pregabalin Versus Placebo in the Treatment of Neuropathic Pain Associated with HIV Neuropathy (Pregabalin A9451066)
    An Open-Label, Extension Safety Trial of Pregabalin in Subjects with Neuropathic Pain Associated with HIV Neuropathy (Pregabalin A0081251)

    These studies investigate whether pregabalin is an effective treatment for painful HIV-associated neuropathy.
  • The Peripheral Neuropathy Consortium
    This multicenter U.S. study focuses on expanding our understanding of the diagnosis and management of painful neuropathy.

The division is also participating in several studies examining the safety and effectiveness of different formulations of botulinum toxin to treat spasticity in the upper and lower extremities following stroke or traumatic brain injury.