The Scientist - Dr. D. Stave Kohtz: "Cancer's Escape Routes"

 – November 30, 2011  –– 

When cancer cells are first discovered, many drugs can blast them into oblivion. But over time, cancers begin to withstand those first line drugs and continue to grow and spread. Cancer cells may also take a page from viruses to switch between resistance and susceptibility, according to a study published November 9 in the American Journal of Pathology. Dr. D. Stave Kohtz, a molecular biologist at Mount Sinai School of Medicine, and his colleagues were studying why ovarian carcinomas sometimes become resistant to a drug, only to become susceptible again after the drug is no longer taken. Such a change is unlikely to be caused by genetic mutations, because those are usually not reversible so quickly, Dr. Kohtz said. Learn more