Cardiovascular Translational Lab Scholar Receives Heart Failure Society of America Fellowship

Dr. Chaanine being presented his HFSA Research Fellowship Award plaque by Martin M. Lewinter, MD, Chair, HFSA Research Committee

Boston, MA
 – September 20, 2011 /Press Release/  –– 

Mount Sinai postdoctoral research fellow Antoine Chaanine, MD, has received a prestigious one-year fellowship from the Heart Failure Society of America's (HFSA) that will support his research into the therapeutic use of gene therapy to reverse heart failure. The announcement of the award took place at HFSA's 15th Annual Scientific Meeting in Boston on September 20, 2011.

Dr. Chaanine, who works in the Hajjar Laboratory (Wiener Family Cardiovascular Research Laboratory) at Mount Sinai's Cardiovascular Research Center, said, "It is a tremendous honor to receive this award. It will enable me to pursue my research and to develop my career as a clinician-scientist in the field of heart failure."

The Heart Failure Society of America research fellowship award is a one-year award given to physicians who are conducting research in the field of heart failure. Dr. Chaanine was awarded the HFSA award for the year June 2011 through June 2012.

The title of the research study for which he received the award is 'Therapeutic cardiac targeted delivery of AAV9-ShBNIP3 attenuates mitophagy and apoptosis in heart failure.' BNIP3 is a molecule involved in cell death and is highly upregulated in heart failure. "We find this molecule to be maladaptive and to worsen cardiac function. Using gene therapy approach, we will attenuate the expression of BNIP3 via the therapeutic delivery of adeno-associated virus containing a small hairpin RNA against BNIP3 mRNA," explained Dr. Chaanine.

The Hajjar Laboratory is part of the Cardiovascular Research Center at Mount Sinai and is focused on gene therapy to prevent or reverse heart failure and other cardiovascular diseases.

The Heart Failure Society of America (HFSA) is a nonprofit educational organization founded in 1994 as the first organized association of heart failure experts. Additional information on HFSA can be found at