Aldosterone Receptor Antagonists

Aldosterone receptor antagonists are a class of medications which work similarly to diuretics, or water pills.  While aldosterone receptor antagonists also help the body get rid of excess water and salt (sodium), they assist the body to retain potassium - an important electrolyte needed by the body and heart to function properly.  There is a lot of research that supports using aldosterone receptor antagonists for patients with heart failure to help them feel better.

Examples of aldosterone receptor antagonists:

  • Spironolactone (Aldactone)
  • Eplerenone (Inspra)

Aldosterone receptor antagonists side effects, similar to those of diuretics, may include:  weakness, dizziness, headache, upset stomach, mild skin rash or itching, muscle cramping, or dry mouth. Consult your doctor if you experience an inability or decreased ability to pass urine, itching or hives, extreme weakness or cramping, dizziness and fainting.

It is important to visit your health care provider regularly to have your blood potassium level monitored and to make sure your kidneys are functioning normally.

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Mount Sinai Heart
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