Interventional Cardiology Research

Led by Dr. Roxana Mehran, MD, Director of Interventional Cardiovascular Research and Clinical Trials, Zena and Michael A. Wiener Cardiovascular Institute, the Cardiac Catheterization Laboratory team has participated in numerous investigator-initiated trials and multi-center trials in the field of coronary interventions. The results of many of these endeavors have let to approval of new drugs and devices by the FDA to improve the outcome and safety of percutaneous interventional procedures.

The most notable research development of 2010 is the CoreValve percutaneous valve pivotal trial, as Mount Sinai was the first to implant this device in the U.S. Another key study initiated at Mount Sinai was renal denervation US pivotal trial for treatment of refractory hypertension. Important scientific publications on various PCI outcomes from the large interventional database repository of approximately 35,000 patients since 2000 continue to advance the field of interventional cardiology in a safe and progressive manner. The professional and highly trained research coordinators and senior research managers are constantly engaged in recruiting patients in research trials and obtaining detailed follow-up of all interventional patients.

Other innovative research activities conducted at Mount Sinai's Cath Lab include:

  • Genomics of Extreme Trait Coronary Artery Disease
  • Ranexa Versus Placebo for Chronic Angina (RIVER PCI)
  • Lipid Core Plaque Imaging
  • Coronary Stent Evaluation for Chronic Total Occlusion
  • Treatment of complex bifurcation lesions with dedicated bifurcation stent (the TRYTON study)
  • Renal Denervation for Hypertension: The Simplicity Trial
  • PET/MRI Ultrasound Imaging for Multi-lesion Coronary Disease
  • Prevention of contrast induced acute kidney injury by the Renal Guard system: a US pivotal trial
  • Revascularization strategy (PCI v. CABG) in pts with unprotected left main disease: THE EXCEL US pivotal Trial
  • Treatment of severe superficial femoral artery stenosis with Drug Coated balloons v. standard balloon angioplasty