A Study to Test Whether Vicadrostat (BI 690517) in Combination With Empagliflozin Helps People With Heart Failure and a Weak Pumping Function of the Left Side of the Heart
This study is open to adults with chronic heart failure (HF) who have a reduced left ventricular ejection fraction (LVEF) of less than 40%. People can join the study if they have been diagnosed with chronic HF at least 3 months before the study. The purpose of this stud...
Age: 18 years - 66+
Gender: All
Adult Congenital Heart Disease International EValuation of the Effectiveness of SGLT2i Registry
This real-world, international registry aims to evaluate the current experience with
sodium-glucose cotransporter 2 inhibitors (SGLT2i) in adult congenital heart disease
(ACHD) patients by investigating the prescription patterns, safety, tolerability, and
potential b...
Age: 18 years - 66+
Gender: All
AI-Enabled Direct-from-ECG Ejection Fraction (EF) Severity Assessment Using COR ECG Wearable Monitor
This prospective, multicenter, cluster-randomized controlled study aims to evaluate the
accuracy of an investigational artificial intelligence (AI) Software as a Medical Device
(SaMD) designed to compute ejection fraction (EF) severity categories based on the
America...
Age: 18 years - 66+
Gender: All
Antithrombotic Activities of Sotagliflozin Vs. Empagliflozin
The availability of Sodium-glucose cotransporter-2 inhibitors (SGLT2-i) has dramatically
altered the management of heart failure (HF) patients, independently of their ejection
fraction and glycemic status. A meta-analysis of 57 studies comparing SGLT2-I monotherapy
v...
Age: 18 years - 66+
Gender: All
Skin Pigment/Pulse Oximeter in Congenital Heart Disease (CHD)
Recent retrospective studies have demonstrated differences between pulse oximeter values (SpO2) and measured arterial oxygen saturation (SaO2) in patients identifying as Black or Hispanic. These retrospective studies have limitations because self-reported race is likely...
Age: Birth - 18 years
Gender: All
A Study of Assessment on Safety and Effectiveness of BWI Pulsed Field Ablation With OMNYPULSE Catheter for the Treatment of Paroxysmal Atrial Fibrillation (PAF)
The purpose of this study is to demonstrate the safety and 12-month effectiveness of the
BWI OMNYPULSE™ pulsed field ablation (PFA) platform for pulmonary vein isolation (PVI) in
the treatment of participants with symptomatic paroxysmal atrial fibrillation (PAF), an
...
Age: 18 - 80 years
Gender: All
REvascularization CHoices Among Under-Represented Groups Evaluation: The RECHARGE Trial - Women
This is a research study in women to compare the outcomes of two procedures that restore
blood flow to the arteries of the heart. In one procedure the blockages are ballooned and
then stented with a small wire mesh tube through a small incision in the wrist or the
gr...
Age: 18 years - 66+
Gender: All
REvascularization CHoices Among Under-Represented Groups Evaluation: The RECHARGE Trial - Minorities
This is a research study in minorities to compare the outcomes of two procedures that
restore blood flow to the arteries of the heart. In one procedure the blockages are
ballooned and then stented with a small wire mesh tube through a small incision in the
wrist or t...
Age: 18 years - 66+
Gender: All
AN INTERNATIONAL, OBSERVATIONAL, BLINDED STUDY TO ASSESS THE PERFORMANCE OF THE CORDIO HEARO SYSTEM
Study Design:
This is an international, multicenter, observational, non-interventional, prospective,
blinded, single-arm, two-period study, to collect patient utterances that will be
retrospectively analyzed to determine the sensitivity and UPNR of the HearO system...
Age: 22 years - 66+
Gender: All
USCOM in Newly Diagnosed FGR Cases
The purpose of this research study is to study the use of an ultrasound measurement
system (USCOM) for patients with newly diagnosed fetal growth restriction (FGR). This
system uses a technology to measure how much blood is being pumped in and out of the
heart, which...
Age: 18 years - 66+
Gender: All
A Study to Investigate the Effect of Lepodisiran on the Reduction of Major Adverse Cardiovascular Events in Adults With Elevated Lipoprotein(a) - ACCLAIM-Lp(a)
The purpose of this study is to evaluate the efficacy of lepodisiran in reducing
cardiovascular risk in participants with high lipoprotein(a) who have cardiovascular
disease or are at risk of a heart attack or stroke. The study drug will be administered
subcutaneousl...
Age: 18 years - 66+
Gender: All
Tier - Palliative Care for Patients with Advanced Heart Failure or Cancer
TIER-PC is an adaptive model of delivering palliative care that provides the right level
of care to the right patients at the right time. It represents an adaption of the Mount
Sinai PALLIATIVE CARE AT HOME (PC@H) program, which delivers home-based palliative care.
T...
Age: 18 years - 66+
Gender: All
PROACTIVE-HF-2 Trial Heart Failure NYHA Class II and III
This is a prospective, multi-center, open label, randomized control clinical trial
evaluating the safety and efficacy of the Cordella™ Pulmonary Artery Sensor System in
NYHA Class II-III Heart Failure Patients (PROACTIVE-HF-2 Trial).
The study contains of 5 arms:
...
Age: 18 years - 66+
Gender: All
US National OCS Heart Perfusion (OHP) Registry
This Registry is a sponsor initiated, multi-center, observational post-approval registry
with independent academic oversight.
Age: Birth - 66+
Gender: All
Impact of Prophylactic Ephedrine on Fetal Heart Tracing and Uterine Tetanic Contraction After CSE
Labor analgesia is an important component of the care of laboring patients. A known side
effect of combined spinal and epidural anesthesia (a type of labor analgesia) is an
increased incidence of category II fetal heart rate tracing (defined below) and low blood
pres...
Age: 18 - 55 years
Gender: Female
A Study to Compare Darolutamide Given With Androgen Deprivation Therapy (ADT) With ADT in Men With Hormone Sensitive Prostate Cancer and Raise of Prostate Specific Antigen (PSA) Levels After Local Therapies
Researchers are looking for a better way to treat men at high-risk of biochemical
recurrence (BCR) of prostate cancer.
BCR means that in men who had prostate cancer and were treated by either surgery and/ or
radiation therapy, the blood level of a specific protein ...
Age: 18 years - 66+
Gender: Male
Diuretics Alone vs. Aortix Endovascular Device for Acute Heart Failure
Aortix is a circulatory support device for chronic heart failure patients on medical
management who have been hospitalized for acute decompensated heart failure (ADHF) and
have persistent congestion despite usual medical therapy.
Eligible ADHF patients with diureti...
Age: 21 years - 66+
Gender: All
Imaging Coronary Microvascular Dysfunction (CMD) Study
Angina is a common clinical symptom of ischemic heart disease, affecting up to 11 million
people in the United States alone, and 112 million people globally. Despite this, 4 in 10
patients undergoing elective coronary angiography for angina and ischemia do not have
e...
Age: 18 years - 66+
Gender: All
Imaging Coronary Microvascular Dysfunction (CMD) Study
Angina is a common clinical symptom of ischemic heart disease, affecting up to 11 million
people in the United States alone, and 112 million people globally. Despite this, 4 in 10
patients undergoing elective coronary angiography for angina and ischemia do not have
e...
Age: 18 years - 66+
Gender: All
Sotagliflozin in Heart Failure With Preserved Ejection Fraction (HFpEF) Patients
The clinical benefits of the dual Sodium-Glucose cotransporter (SGLT) 1 and 2-inhibition
have recently been reported in two clinical trials. The SOLOIST reported the benefits of
sotagliflozin in Type-2 Diabetes Mellitus (T2DM) patients hospitalized for worsening of
H...
Age: 18 years - 66+
Gender: All