A Study of Assessment on Safety and Effectiveness of BWI Pulsed Field Ablation With OMNYPULSE Catheter for the Treatment of Paroxysmal Atrial Fibrillation (PAF)
The purpose of this study is to demonstrate the safety and 12-month effectiveness of the
BWI OMNYPULSE™ pulsed field ablation (PFA) platform for pulmonary vein isolation (PVI) in
the treatment of participants with symptomatic paroxysmal atrial fibrillation (PAF), an
...
Age: 18 - 80 years
Gender: All
AN INTERNATIONAL, OBSERVATIONAL, BLINDED STUDY TO ASSESS THE PERFORMANCE OF THE CORDIO HEARO SYSTEM
Study Design:
This is an international, multicenter, observational, non-interventional, prospective,
blinded, single-arm, two-period study, to collect patient utterances that will be
retrospectively analyzed to determine the sensitivity and UPNR of the HearO sys...
Age: 22 years - 66+
Gender: All
A Study to Investigate the Effect of Lepodisiran on the Reduction of Major Adverse Cardiovascular Events in Adults With Elevated Lipoprotein(a) - ACCLAIM-Lp(a)
The purpose of this study is to evaluate the efficacy of lepodisiran in reducing
cardiovascular risk in participants with high lipoprotein(a) who have cardiovascular
disease or are at risk of a heart attack or stroke. The study drug will be administered
subcutaneousl...
Age: 18 years - 66+
Gender: All
Tier - Palliative Care For Patients With Advanced Heart Failure or Cancer
TIER-PC is an adaptive model of delivering palliative care that provides the right level of
care to the right patients at the right time. It represents an adaption of the Mount Sinai
PALLIATIVE CARE AT HOME (PC@H) program, which delivers home-based palliative care. ...
Age: 18 years - 66+
Gender: All
PROACTIVE-HF-2 Trial Heart Failure NYHA Class II and III
This is a prospective, multi-center, open label, randomized control clinical trial evaluating
the safety and efficacy of the Cordella™ Pulmonary Artery Sensor System in NYHA Class II-III
Heart Failure Patients (PROACTIVE-HF-2 Trial).
The study contains of 5 arms...
Age: 18 years - 66+
Gender: All
Impact of Prophylactic Ephedrine on Fetal Heart Tracing and Uterine Tetanic Contraction After CSE
Labor analgesia is an important component of the care of laboring patients. A known side
effect of combined spinal and epidural anesthesia (a type of labor analgesia) is an increased
incidence of category II fetal heart rate tracing (defined below) and low blood pre...
Age: 18 - 55 years
Gender: Female
A Study to Find Out if ASP5354 Can Clearly Help Show the Ureter During Surgery
The ureter is the tube that carries urine from the kidneys to the bladder. It is
difficult for surgeons to see the ureter during abdominal surgery. This could lead to
injuring the ureter which, although rare, could be serious.
This study is about a potential new me...
Age: 12 years - 66+
Gender: All
A Study to Test Asundexian for Preventing a Stroke Caused by a Clot in Participants After an Acute Ischemic Stroke or After a High-risk Transient Ischemic Attack, a So-called Mini Stroke
Researchers are looking for a better way to prevent an ischemic stroke which occurs when
a blood clot travelled to the brain in people who within the last 72 hours had:
- an acute stroke due to a blood clot that formed outside the heart (acute
non-cardioembolic i...
Age: 18 years - 66+
Gender: All
Diuretics Alone vs. Aortix Endovascular Device for Acute Heart Failure
Aortix is a circulatory support device for chronic heart failure patients on medical
management who have been hospitalized for acute decompensated heart failure (ADHF) and
have persistent congestion despite usual medical therapy.
Eligible ADHF patients with diureti...
Age: 21 years - 66+
Gender: All
Imaging Coronary Microvascular Dysfunction (CMD) Study
Angina is a common clinical symptom of ischemic heart disease, affecting up to 11 million
people in the United States alone, and 112 million people globally. Despite this, 4 in 10
patients undergoing elective coronary angiography for angina and ischemia do not have
...
Age: 18 years - 66+
Gender: All
Sotagliflozin in Heart Failure With Preserved Ejection Fraction (HFpEF) Patients
The clinical benefits of the dual Sodium-Glucose cotransporter (SGLT) 1 and 2-inhibition
have recently been reported in two clinical trials. The SOLOIST reported the benefits of
sotagliflozin in Type-2 Diabetes Mellitus (T2DM) patients hospitalized for worsening of
H...
Age: 18 years - 66+
Gender: All
ALTERRA Post-Approval Study
This study will monitor device performance and outcomes in subjects undergoing implantation
of the Edwards SAPIEN 3 Transcatheter Pulmonary Valve System with Alterra Adaptive Prestent
in the post-approval setting
Age: Birth - 66+
Gender: All
Pediatric Influence of Cooling Duration on Efficacy in Cardiac Arrest Patients (P-ICECAP)
This is a multicenter trial to establish the efficacy of cooling and the optimal duration
of induced hypothermia for neuroprotection in pediatric comatose survivors of cardiac
arrest.
The study team hypothesizes that longer durations of cooling may improve either t...
Age: 2 days - 17 years
Gender: All
Ultrafiltration Versus IV Diuretics in Worsening Heart Failure
The REVERSE-HF study is a randomized controlled trial to evaluate clinical outcomes of
adjustable ultrafiltration with the Aquadex System as compared to adjustable IV loop
diuretics in patients with worsening heart failure (HF) and fluid overload.
Age: 18 years - 66+
Gender: All
MINDS Imaging Ancillary Study
This study is an ancillary study to the NHLBI-funded Pediatric Heart Network (PHN)
"Multi-Institutional Neurocognitive Discovery Study" (MINDS) in Adult Congenital Heart
Disease (ACHD). The MINDS-ACHD" study will recruit 500 complex CHD patients between18-30
years...
Age: 18 - 30 years
Gender: All
The Effects of Entrainment on Respiratory Stability and Cerebral Oxygenation in Preterm Infants
Infants born prematurely at will be asked to participate in this randomized controlled trial
at a corrected gestational age of 24-37 weeks. Infants will be randomly selected to each of
the two groups: intervention and control. Infants in the treatment group will rec...
Age: 24 - 37 weeks
Gender: All
ERTU-SODIUM: Study on the Effects of Ertugliflozin on Sodium Storage, Interstitial Volume, and Plasma Volume in HFrEF
The overall hypothesis is that treatment with the SGLT2 inhibitor Ertugliflozin induces a differential regulation in interstitial fluid vs plasma volume, with more reduction of the volume from the interstitial fluid than from the circulating plasma volume, which results...
Age: 18 years - 66+
Gender: All
Harmony TPV Post-Approval Study
The purpose of this study is to characterize the functionality of transcatheter
implantation of the Medtronic Harmony Transcatheter Pulmonary Valve (TPV) achieved by
real-world implanters.
Age: Birth - 66+
Gender: All
Assessment of Patterns of Patient Reported Outcomes in Adults With Congenital Heart Disease - International Study II
This is an international, cross-sectional and descriptive study that aims to investigate differences in patient-reported outcome measures (PROMs) and patient-reported experience measures (PREMs) and that aims to explore the profile and healthcare needs of adults with co...
Age: 18 years - 66+
Gender: All
Comparative Effectiveness of Telemedicine in Primary Care
Leveraging a natural experiment approach, the investigators will examine rapidly changing
telemedicine and in-person models of care during and after the COVID-19 crisis to determine
whether certain patients could safely choose to continue telemedicine or
telemedic...
Age: 19 years - 66+
Gender: All