Blood Test May Predict Severity of Peanut and Seafood Allergies
A blood test may help to predict which people will have severe allergic reactions to foods according to a new study led by Mount Sinai researchers and published online today in the The Annals of Allergy, Asthma & Immunology.
To detect food allergies, physicians typically use skin prick tests or blood tests that measure levels of allergen-specific IgE (sIgE), a protein made by the immune system. However, these tests cannot predict the severity of allergic reactions. Oral food challenges, in which specific allergens are given to patients to ingest under physician supervision to test for signs or symptoms of an allergic reaction, remain the gold standard for diagnosing food allergy even though the tests themselves can trigger severe reactions.
In the newly published study, Mount Sinai researchers from The Mindich Child Health and Development Institute and the Jaffe Food Allergy Institute report that by counting the numbers of one type of immune cell activated by exposure to a food, a blood test may help to predict the severity of each person’s allergic reaction. The immune cell measured is the basophil, and the blood test, the basophil activation test or BAT, requires only a small blood sample and provides quick results.
“Having blood drawn for BAT is a much less difficult procedure than food challenges.” says first author Ying Song, MD. “Although food challenges are widely practiced, they carry the risk of severe allergic reactions, and we hope that BAT can be developed further to provide accurate information in a safe manner,” says Dr. Song, also a researcher in the Jaffe Food Allergy Institute at The Mount Sinai Hospital.
“Although the blood basophil activation test has been shown to be an important addition to the tools available for discriminating between allergic and non-allergic individuals and predicting the severity of food allergy reactions, at this time it is only approved for research purposes,” says senior author Xiu-Min Li, MD, Professor of Pediatrics at the Icahn School of Medicine.
Investigators took blood samples from 67 patients, ages 12 to 45 years, who also underwent a food challenge with a placebo or with peanut, tree nut, fish, shellfish, or sesame. The goal was to see if the BAT results would correlate with food challenge results. The study was double blinded, so neither researchers nor patients knew which person received a placebo or one of the allergens, which were administered at random.
Before the randomized food challenge, researchers collected blood from all patients and analyzed the results, which showed a strong correlation between BAT data and food challenge severity scores. This finding provides evidence that BAT may be able to reduce the need for food challenges not only for peanut, but also for tree nut, fish, shellfish, and sesame and perhaps for other foods.
About the Mount Sinai Health System
The Mount Sinai Health System is an integrated health system committed to providing distinguished care, conducting transformative research, and advancing biomedical education. Structured around seven hospital campuses and a single medical school, the Health System has an extensive ambulatory network and a range of inpatient and outpatient services—from community-based facilities to tertiary and quaternary care.
The System includes approximately 7,100 primary and specialty care physicians; 12 joint-venture ambulatory surgery centers; more than 140 ambulatory practices throughout the five boroughs of New York City, Westchester, Long Island, and Florida; and 31 affiliated community health centers. Physicians are affiliated with the renowned Icahn School of Medicine at Mount Sinai, which is ranked among the highest in the nation in National Institutes of Health funding per investigator. The Mount Sinai Hospital is in the "Honor Roll" of best hospitals in America, ranked No. 15 nationally in the 2016-2017 "Best Hospitals" issue of U.S. News & World Report. The Mount Sinai Hospital is also ranked as one of the nation's top 20 hospitals in Geriatrics, Gastroenterology/GI Surgery, Cardiology/Heart Surgery, Diabetes/Endocrinology, Nephrology, Neurology/Neurosurgery, and Ear, Nose & Throat, and is in the top 50 in four other specialties. New York Eye and Ear Infirmary of Mount Sinai is ranked No. 10 nationally for Ophthalmology, while Mount Sinai Beth Israel, Mount Sinai St. Luke's, and Mount Sinai West are ranked regionally. Mount Sinai's Kravis Children's Hospital is ranked in seven out of ten pediatric specialties by U.S. News & World Report in "Best Children's Hospitals."