Sci-Tech Today - "Discovery May Help Cocaine Addiction Treatment"
Eric J. Nestler, MD, PhD, Nash Family Professor and Chair of Neuroscience, and Director of the Friedman Brain Institute at the Icahn School of Medicine, and colleagues said preclinical research reveals how an abundant enzyme and synaptic gene affect a key reward circuit in the brain, changing the ways genes are affected. The research team studied cocaine addiction in a mouse model. They found regular cocaine use caused the levels of enzyme PARP-1 – also known as poly (ADP-ribosylation polymerase-1 – to increase. “The higher levels of the enzyme are linked to causing cocaine addition,” the researchers said. Learn more