"Infliximab May Effectively Treat Pediatric Crohn’s Over The Long Term" - Marilynn Larkin
Infliximab may be an effective long-term treatment for children with Crohn’s disease, although optimization will likely be needed. Keith Benkov, MD, associate professor of pediatrics and gastroenterology at the Icahn School of Medicine at Mount Sinai said that, “While infliximab is very effective in controlling inflammation and complications associated with Crohn’s, the major problem with its use has been its durability in effectiveness.” One caveat, Dr. Benkov added, is that close to two-thirds were taking immunomodulatory, which is a little bit higher than usually seen. Immunomodulators have been shown to increase the sustainabiluity of infliximab but also have the potential for increasing side effects. “Because it is a retrospective study, there are additional biases,” added Dr. Benkov.
- Keith Benkov, MD, Associate Professor, Pediatrics, Gastroenterology, Icahn School of Medicine at Mount Sinai